Results 71 to 80 of about 97,423,779 (276)

Serum levels of angiopoietin-2 and vascular endothelial growth factor in severe refractory asthma

Egyptian Journal of Chest Disease and Tuberculosis, 2014
Background: Airway and vascular remodeling may play a prominent role in the clinical severity of severe refractory asthma (SRA). Angiopoietin-1 (Ang-1) is an essential mediator of angiogenesis by establishing vascular integrity, whereas angiopoietin-2 ...
Mohamed Hantera, Hamed Abd El-Hafiz, Amira Y. Abdelnaby   +2 more
doaj   +1 more source

Drug repurposing screen identifies Foxo1-dependent angiopoietin-2 regulation in sepsis [PDF]

, 2015
OBJECTIVE: The recent withdrawal of a targeted sepsis therapy has diminished pharmaceutical enthusiasm for developing novel drugs for the treatment of sepsis.
Rajakumar, Augustine, Schrimpf, Claudia, Maski, Manish R., Ahmed, Asif, Maski, Manish R, Berghelli, Anthony V., Donnino, Michael W, Ghosh, Chandra C., Parikh, Samir M., Kielstein, Jan T, Abid, Tanaz, Milam, Katelyn E., Ghosh, Chandra C, Parikh, Samir M, Thamm, Kristina, Aird, William C., Thickett, David, Milam, Katelyn E, Berghelli, Anthony V, Santel, Ansgar, Haller, Hermann, Wang, Keqin, Donnino, Michael W., David, Sascha, Kielstein, Jan T., Chase, Maureen, Aird, William C   +26 more
core   +1 more source

Circulating markers of the endothelial angiopoietin/Tie2 system.

, 2023
Circulating levels of angiopoietin-1 (A), angiopoietin-2 (B), angiopoietin-2/1 ratio (C) and soluble Tie2 (D) in plasma of Tie2+/+ male (white bars), Tie2+/+ female (grey bars), Tie2+/- male (striped white bars) and Tie2+/- female (striped grey bars ...
Anoek L. I. van Leeuwen (8839811), Elise Beijer (17403462), Grietje Molema (64356), Roselique Ibelings (17403465), Matijs van Meurs (358888), Charissa E. van den Brom (3156441), Joris J. T. H. Roelofs (9302018), Nicole A. M. Dekker (10807289), Marjolein R. A. van der Steen (17403468)   +8 more
core   +1 more source

Splenic Tropism and Spleen‐Modulated Systemic Inflammation in Acute Plasmodium vivax Malaria

American Journal of Hematology, EarlyView.
ABSTRACT In chronic Plasmodium vivax (Pv) infection, the spleen accounts for over 98% of total‐body parasite biomass. Whether splenic tropism also occurs in acute infection and how the spleen influences pathogenesis have not been systematically explored. In Papua, Indonesia, we compared clinical and hematology data in 24 spleen‐intact and 25 previously
Steven Kho, Hasrini Rini, Noy N. Kambuaya, Syawal Satria, Freis Candrawati, Putu A. I. Shanti, King Alexander, Benediktus Andries, Aisah R. Amelia, Anjana Rai, Kim A. Piera, Agatha M. Puspitasari, Ristya Amalia, Pak Prayoga, Leo Leonardo, Maulina Hafidzah, Theo Situmorang, Dewi S. Margayani, Desandra A. Rahmayenti, Pengxing Cao, Enny Kenangalem, Leily Trianty, Damian Oyong, Julie A. Simpson, Rintis Noviyanti, Pierre A. Buffet, Jeanne R. Poespoprodjo, Nicholas M. Anstey   +27 more
wiley   +1 more source

Prognostic and Pathogenic Role of Angiopoietin-1 and -2 in Pneumonia

, 2018
RATIONALE: During pneumonia, pathogen-host interaction evokes inflammation and lung barrier dysfunction. Tie2-activation by Angiopoietin-1 reduces, while Tie2-blockade by Angiopoietin-2 increases inflammation and permeability during sepsis.
Norbert Weissmann, Markus Scholz, Mitchell, Tim, Jörg Kaufmann, Weissmann, Norbert, Stefano Aliberti, Neuhauß, Anne-Kathrin, Mitchell, Timothy J, Norbert Suttorp, Aliberti, Stefano, Katrin Reppe, Anne-Kathrin Neuhauß, Ansgar Santel, Timothy J. Mitchell, Santel, Ansgar, Gutbier, Birgitt, Scholz, Markus, Witzenrath, Martin, Suttorp, Norbert, Birgitt Gutbier, Carolin Ehrler, Morawietz, Lars, Stefan Hippenstiel, Martin Witzenrath, Ehrler, Carolin, Hippenstiel, Stefan, Lars Morawietz, Reppe, Katrin, Kaufmann, Jörg   +28 more
core   +1 more source

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source

Expression and Predictive Value of Angiopoietin-2 in Pulmonary Hypertension Associated with Chronic Obstructive Pulmonary Disease

COPD
Clear and effective treatment for pulmonary hypertension (PH) caused by chronic obstructive pulmonary disease (COPD) has not been established, and thus promptly identifying patients with PH is of particular importance.
Ruiqin Ni, Mengrong Xie, Jingying Zhang, Mingmei Zhong   +3 more
doaj   +1 more source

Effect of HIV‐1 Infection on Angiopoietin 1 and 2 Levels and Measures of Microvascular and Macrovascular Endothelial Dysfunction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Individuals infected with HIV have an increased risk of developing cardiovascular disease; yet, the underlying mechanisms remain unknown. Recent evidence has implicated the Tie‐2 tyrosine kinase receptor system and its associated ligands ANG1 (
Anjali B. Thakkar, Yifei Ma, Mark Dela Cruz, Yuaner Wu, Victor Arechiga, Shreya Swaminathan, Peter Ganz, Alan H. B. Wu, Rebecca Scherzer, Steven Deeks, Priscilla Y. Hsue   +10 more
doaj   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Lean ZSF1 rats in basic research on heart failure with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 1474-1478, April 2025.
Abstract Aims ZSF1 obese rats harbouring two mutant leptin receptor alleles (Leprcp and Leprfa) develop metabolic syndrome and heart failure with preserved ejection fraction (HFpEF), making them a widely used animal model in cardiometabolic research.
Petra Büttner, Antje Augstein, Mahmoud Abdellatif, André Lourenço, Adelino Leite‐Moreira, Inês Falcão‐Pires, Sarah Werner, Holger Thiele, Simon Sedej, Antje Schauer, Volker Adams   +10 more
wiley   +1 more source