Results 51 to 60 of about 97,423,779 (276)

Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats

, 2003
Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) have been identified as ligands with different effector functions of the vascular assembly and maturation-mediating receptor tyrosine kinase Tie-2.
Weiss, C, Augustin, HG, Fiedler, U, Krissl, T, Martiny-Baron, G, Deutsch, U, Koidl, S, Koblizek, T, Marmé, D   +8 more
core   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Selective adipocyte loss of Angiopoietin-2 prompts female-specific obesity and metabolic syndrome

Molecular Metabolism, 2022
Thermogenic fat differentiation and function can be promoted through multiple pathways, resulting in a common cell phenotype characterized by the expression of Uncoupling Protein-1 and the ability to dissipate energy, but local and systemic stimuli are ...
Bin Ni, Shanshan Chen, Kathleen A. Ryan, Michael L. Maitland, Jared S. Farrar, Martin Witzenrath, Birgitt Gubier, Cindy Serdjebi, Karine Bertotti, Rui Wang, Fadi N. Salloum, Luigi Marino, Braxton D. Mitchell, Francesco S. Celi   +13 more
doaj   +1 more source

A Rare De Novo Missense Mutation in IFT122 Confers a Genetic Susceptibility Factor of Idiopathic Pediatric Uveitis Via Trio‐based Whole‐Exome Sequencing

Advanced Science, EarlyView.
A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou, Jiaxing Huang, Yilin Wang, Xingran Li, Xianyang Liu, Lingyu Dai, Hongshun Li, Qingfeng Wang, Jiangyi Liu, Guannan Su, Wanyun Zhang, Yang Deng, Qingfeng Cao, Yujie Lai, Xiang Luo, Changwei Huang, Ling Chen, Shengping Hou, Peizeng Yang   +18 more
wiley   +1 more source

Angiopoietin-2 in chronic renal failure patients on hemodialysis: Relationship with glomerular filtration rate in the predialysis stages

The Egyptian Journal of Internal Medicine, 2013
Introduction Cardiovascular disease has increased as a complication of chronic kidney disease even in the absence of diabetes or hypertension. Angiopoietin-1 and 2 are 55 kDa antagonistic nonredundant gatekeepers of endothelial activation and thus are ...
Fatma A Attia, Nagwa A Mohammed, Al-Shymaa A Ibrahim   +2 more
doaj   +1 more source

The Role of Angiopoietine-2 in the Diagnosis and Prognosis of Sepsis [PDF]

The Journal of Critical Care Medicine, 2015
Abstract Introduction : Angiopoietin-2 (ANG-2) is a new biomarker whose blood-serum values increase in sepsis and its expression is elevated in line with the severity of the degree of inflammation.
Janos, Szederjesi, Emoke, Almasy, Alexandra, Lazar, Adina, Huțanu, Anca, Georgescu   +4 more
openaire   +2 more sources

Angiopoietin-1 levels and other baseline parameters as predictors of overall mortality/transplant in patients with different PH subtypes.

, 2016
Angiopoietin-1 levels and other baseline parameters as predictors of overall mortality/transplant in patients with different PH subtypes.
Manuel Jonas Richter (2586910), Natascha Sommer (2586913), Ralph Schermuly (3324684), Thomas Schmidt (168952), Henning Gall (759343), Svenja Lena Tiede (3324687), Werner Seeger (5494), Hossein Ardeschir Ghofrani (142879)   +7 more
core   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Angiopoietin-2 outperforms other endothelial biomarkers associated with severe acute kidney injury in patients with severe sepsis and respiratory failure

Critical Care, 2021
Background Endothelial dysfunction and injury is a major pathophysiologic feature of sepsis. Sepsis is also the most frequent cause of acute kidney injury (AKI) in critically ill patients.
Wen-Kuang Yu, J. Brennan McNeil, Nancy E. Wickersham, Ciara M. Shaver, Julie A. Bastarache, Lorraine B. Ware   +5 more
doaj   +1 more source

Angiopoietin-2 level as a tool for cardiovascular risk stratification in hypertensive type 2 diabetic subjects

, 2019
Objectives: This observational cross-sectional study aimed to investigate the relationship between serum Angiopoietin-2 (Ang-2) levels and cardiovascular (CVD) risk factors in drug controlled hypertensive diabetic subjects without cardiovascular ...
Shaik Sarfaraz Nawaz (5153894), Khalid Al-Rubeaan (526186), Khalid Siddiqui (5153888), Mohammad T. Al Otaibi (5153897), Salini Scaria Joy (5153891)   +4 more
core   +1 more source