Results 31 to 40 of about 97,423,779 (276)

Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. [PDF]

, 2009
BACKGROUND: Limited tools exist to identify which individuals infected with Plasmodium falciparum are at risk of developing serious complications such as cerebral malaria (CM). The objective of this study was to assess serum biomarkers that differentiate
Hawkes, Michael, Nimerta Rajwans, Michael Hawkes, Kevin C Kain, Lafferty, Erin I., John, Chandy C, Sornchai Looareesuwan, Srivicha Krudsood, Tangpukdee, Noppadon, Lafferty, Erin I, Looareesuwan Sornchai, Fiona E Lovegrove, Krudsood, Srivicha, John Chandy C., Rajwans, Nimerta, Opoka, Robert, Noppadon Tangpukdee, Hawkes Michael, Lafferty Erin I., Lovegrove Fiona E., Kain, Kevin C, Looareesuwan, Sornchai, Lovegrove, Fiona E., Opoka Robert O., Krudsood Srivicha, Kain, Kevin C., Erin I Lafferty, Kain Kevin C., Robert O Opoka, Lovegrove, Fiona E, Rajwans Nimerta, John, Chandy C., W Conrad Liles, Liles, W. Conrad, Tangpukdee Noppadon, Liles, W Conrad, Chandy C John, Opoka, Robert O, Liles W. Conrad   +38 more
core   +1 more source

Female sex protects against renal edema, but not lung edema, in mice with partial deletion of the endothelial barrier regulator Tie2 compared to male sex.

PLoS ONE, 2023
BackgroundThe endothelial angiopoietin/Tie2 system is an important regulator of endothelial permeability and targeting Tie2 reduces hemorrhagic shock-induced organ edema in males.
Anoek L I van Leeuwen, Elise Beijer, Roselique Ibelings, Nicole A M Dekker, Marjolein R A van der Steen, Joris J T H Roelofs, Matijs van Meurs, Grietje Molema, Charissa E van den Brom   +8 more
doaj   +1 more source

Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes

BMC Nephrology, 2020
Background We previously identified two acute kidney injury (AKI) sub-phenotypes (AKI-SP1 and AKI-SP2) with different risk of poor clinical outcomes and response to vasopressor therapy.
Pavan K. Bhatraju, Max Cohen, Ryan J. Nagao, Eric D. Morrell, Susanna Kosamo, Xin-Ya Chai, Robin Nance, Victoria Dmyterko, Joseph Delaney, Jason D. Christie, Kathleen D. Liu, Carmen Mikacenic, Sina A. Gharib, W. Conrad Liles, Ying Zheng, David C. Christiani, Jonathan Himmelfarb, Mark M. Wurfel   +17 more
doaj   +1 more source

Multiple Effects of Angiopoietin-2 Blockade on Tumors [PDF]

Cancer Cell, 2011
In this issue of Cancer Cell, Mazzieri, Pucci, and colleagues describe the marked effects of inhibiting the proangiogenic cytokine, Angiopoietin-2, on tumor angiogenesis and progression in spontaneous tumor models, as well as the proangiogenic functions of TIE2-expressing macrophages.
Lewis, Claire E., Ferrara, Napoleone
openaire   +2 more sources

Circulating angiopoietin-2 is a marker for early cardiovascular disease in children on chronic dialysis.

PLoS ONE, 2013
Cardiovascular disease (CVD) is increasingly recognised as a complication of childhood chronic kidney disease (CKD) even in the absence of diabetes and hypertension.
Rukshana C Shroff, Karen L Price, Maria Kolatsi-Joannou, Alexandra F Todd, David Wells, John Deanfield, Richard J Johnson, Lesley Rees, Adrian S Woolf, David A Long   +9 more
doaj   +1 more source

Angiopoietin-2 Is Implicated in the Regulation of Tumor Angiogenesis [PDF]

The American Journal of Pathology, 2001
We addressed the effect of angiopoietin expression on tumor growth and metastasis. Overexpression of angiopoietin-2 (Ang-2) in Lewis lung carcinoma and TA3 mammary carcinoma cells inhibited their ability to form metastatic tumors and prolonged the survival of mice injected with the corresponding transfectants.
Q, Yu, I, Stamenkovic
openaire   +2 more sources

New molecular mediators in tumor angiogenesis [PDF]

, 2007
Angiogenesis is essential for tumor growth and progression. It has been demonstrated that tumor growth beyond a size 1 to 2 mm3 requires the induction of new vessels.
Jonas, Dietger, Beecken, Wolf-Dietrich, Kramer, Wolfgang   +2 more
core   +1 more source

sj-docx-1-vrd-10.1177_24741264221126061 – Supplemental material for Intravitreal Nesvacumab (Anti-Angiopoietin-2) Plus Aflibercept in Neovascular AMD: Phase 2 ONYX Randomized Trial

, 2022
Supplemental material, sj-docx-1-vrd-10.1177_24741264221126061 for Intravitreal Nesvacumab (Anti-Angiopoietin-2) Plus Aflibercept in Neovascular AMD: Phase 2 ONYX Randomized Trial by Jeffrey S. Heier, Allen C. Ho, David S. Boyer, Karl Csaky, Robert Vitti,
Friedrich Asmus (14327961), Lorah Perlee (14327955), Robert Vitti (14327952), Karl Csaky (2686657), Allen C. Ho (13152645), Karen W. Chu (14327958), Sergio Leal (9140146), Oliver Zeitz (71487), Thomas Schmelter (796965), Yenchieh Cheng (14327964), Jeffrey S. Heier (14327946), David S. Boyer (14327949), David M. Brown (475802)   +12 more
core   +1 more source

Endothelial glycocalyx breakdown is mediated by angiopoietin-2 [PDF]

Cardiovascular Research, 2017
The endothelial glycocalyx (eGC), a carbohydrate-rich layer lining the luminal surface of the endothelium, provides a first vasoprotective barrier against vascular leakage and adhesion in sepsis and vessel inflammation. Angiopoietin-2 (Angpt-2), an antagonist of the endothelium-stabilizing receptor Tie2 secreted by endothelial cells, promotes vascular ...
Alexander, Lukasz, Carina, Hillgruber, Hans, Oberleithner, Kristina, Kusche-Vihrog, Hermann, Pavenstädt, Alexandros, Rovas, Bettina, Hesse, Tobias, Goerge, Philipp, Kümpers   +8 more
openaire   +2 more sources

Angiopoietin-2: Development of inhibitors for cancer therapy [PDF]

Current Oncology Reports, 2009
Angiopoietin-2 (Ang2) is a member of the Ang family, which plays an important role in angiogenesis during the development and growth of human cancers. Ang2's role in angiogenesis generally is considered as an antagonist for Ang1, inhibiting Ang1-promoted Tie2 signaling, which is critical for blood vessel maturation and stabilization.
Bo, Hu, Shi-Yuan, Cheng
openaire   +2 more sources