Results 11 to 20 of about 97,423,779 (276)

Normalization of the serum angiopoietin-1 to angiopoietin-2 ratio reflects response in refractory/resistant multiple myeloma patients treated with bortezomib

Haematologica, 2008
Neoangiogenesis is involved in the pathophysiology of multiple myeloma and angiopoietins possibly contribute to myeloma-induced neovascularization. Bortezomib’s antineoplastic potential includes an anti-angiogenic effect.
Konstantinos Anargyrou, Evangelos Terpos, Theodoros P. Vassilakopoulos, Anastasia Pouli, Sotirios Sachanas, Tatiana Tzenou, Stavroula Masouridis, Dimitrios Christoulas, Maria K. Angelopoulou, Evangelia M. Dimitriadou, Christina Kalpadakis, Konstantinos Tsionos, Panayiotis Panayiotidis, Meletios A. Dimopoulos, Gerassimos A. Pangalis, Marie-Christine Kyrtsonis   +15 more
doaj   +3 more sources

Angiopoietin-2 is associated with albuminuria and microinflammation in chronic kidney disease. [PDF]

PLoS ONE, 2013
Although cardiovascular disease (CVD) is the leading cause of mortality in patients with chronic kidney disease (CKD), the pathophysiology is not thoroughly understood. Given that elevated albuminuria or circulating angiopoietin-2 associates with CVD and
Fan-Chi Chang, Tai-Shuan Lai, Chih-Kang Chiang, Yung-Ming Chen, Ming-Shiou Wu, Tzong-Shinn Chu, Kwan-Dun Wu, Shuei-Liong Lin   +7 more
doaj   +3 more sources

Reduced angiopoietin-2 as a predictive biomarker for clomiphene citrate resistance in polycystic ovary syndrome

Journal of Human Reproductive Sciences, 2021
Background: Even though angiopoeitin-2 and interleukin (IL)-23 are known to be altered in polycystic ovary syndrome (PCOS), their association with clomiphene citrate (CC) resistance has not been studied. Aim: The objective of the study was to investigate
Luxmipratha Rajendiran, Hanumanthappa Nandeesha, Thyagaraju Chitra   +2 more
doaj   +2 more sources

Angiopoietin-2–Induced Arterial Stiffness in CKD [PDF]

Journal of the American Society of Nephrology, 2014
The mechanism of vascular calcification in CKD is not understood fully, but may involve collagen deposition in the arterial wall upon osteo/chondrocytic transformation of vascular smooth muscle cells (VSMCs). Increased levels of circulating angiopoietin-2 correlate with markers of CKD progression and angiopoietin-2 regulate inflammatory responses ...
Fan-Chi, Chang, Wen-Chih, Chiang, Ming-Hsuan, Tsai, Yu-Hsiang, Chou, Szu-Yu, Pan, Yu-Ting, Chang, Pei-Ying, Yeh, Yi-Ting, Chen, Chih-Kang, Chiang, Yung-Ming, Chen, Tzong-Shinn, Chu, Kwan-Dun, Wu, Shuei-Liong, Lin   +12 more
openaire   +3 more sources

Angiopoietin 2 alters pancreatic vascularization in diabetic conditions. [PDF]

PLoS ONE, 2012
AIMS/HYPOTHESIS: Islet vascularization, by controlling beta-cell mass expansion in response to increased insulin demand, is implicated in the progression to glucose intolerance and type 2 diabetes. We investigated how hyperglycaemia impairs expansion and
Sophie Calderari, Cécile Chougnet, Maud Clemessy, Hervé Kempf, Pierre Corvol, Etienne Larger   +5 more
doaj   +7 more sources

Advanced Glycation End-Products and Hyperglycemia Increase Angiopoietin-2 Production by Impairing Angiopoietin-1-Tie-2 System

Journal of Diabetes Research, 2019
The angiopoietin-Tie-2 system plays a crucial role in the maintenance of endothelial integrity. Hyperglycemia and advanced glycation end-products (AGEs) are involved in endothelial cell dysfunction responsible of the pathogenesis of microvascular ...
Alessandra Puddu, Roberta Sanguineti, Davide Maggi, Massimo Nicolò, Carlo E. Traverso, Renzo Cordera, Giorgio L. Viviani   +6 more
doaj   +3 more sources

Endothelial Permeability and the Angiopoietin/Tie2 System Following Mild and Severe COVID-19

Artery Research, 2023
Endotheliopathy plays a role in the development of acute kidney and lung injury in COVID-19, probably due to inflammation, endothelial permeability, vascular leakage and edema formation. This study examined alterations in the circulation of patients with
Carolien Volleman, Roselique Ibelings, Alexander P. J. Vlaar, Charissa E. van den Brom, The Amsterdam UMC COVID-19 Biobank Study Group   +4 more
doaj   +2 more sources

Assessment of peripheral blood concentration of angiopoietin 1, angiopoietin 2 and Tie-2 (a tyrosine kinase receptor) of patients with goitre treated surgically

Videosurgery and Other Miniinvasive Techniques, 2011
Introduction: Blood vessel formation by angiogenesis is essential for goitre development. Angiopoietin 1 (Ang-1),angiopoietin 2 (Ang-2) and Tie-2 receptor (rTie-2) are involved in part of angiogenesis.
Joanna Kalupa, Krzysztof Kuzdak, Krzysztof Kołomecki   +2 more
doaj   +1 more source

The Role of Angiopoietin-2 in Post-Burn Pneumonia. [PDF]

Eur Burn J
Background: Pneumonia contributes to post-burn morbidity and mortality. Understanding the mechanisms that predispose burn patients to pneumonia is crucial to both stratifying patients at increased risk and developing targeted interventions. Methods: A prospective observational study was conducted with 47 human patients who sustained large burn injuries
Murray MG, Johnson RM, Plum AB, Carbajal Garcia N, Galicia KE, Brady A, Kipp M, Helenowski IB, Tschann MM, Guzior C, Gonzalez RP, Choudhry MA, Kubasiak JC.   +12 more
europepmc   +4 more sources

Angiopoietin-2 in experimental colitis [PDF]

Inflammatory Bowel Diseases, 2010
The pathophysiology of inflammatory bowel disease (IBD) includes leukocyte infiltration, blood and lymphatic remodeling, weight loss and protein enteropathy. The roles of angiopoietin-2 (Ang-2) in initiating gut inflammation, leukocyte infiltration and angiogenesis are not well understood.Disease activity index, histopathological scoring ...
Vijay C, Ganta, Walter, Cromer, Ginny L, Mills, James, Traylor, Merilyn, Jennings, Sarah, Daley, Benjamin, Clark, J Michael, Mathis, Michael, Bernas, Moheb, Boktor, Paul, Jordan, Marlys, Witte, J Steven, Alexander   +12 more
openaire   +2 more sources