Results 21 to 30 of about 75,908 (219)

The angiopoietin-like protein 4, apolipoprotein C3, and lipoprotein lipase axis is disrupted in patients with rheumatoid arthritis [PDF]

Arthritis Research & Therapy, 2022
Background Modulators of triglyceride metabolism include lipoprotein lipase (LPL), angiopoietin-like protein 4 (ANGPTL4), and apolipoprotein C-3 (ApoC3).
Laura de Armas-Rillo, Juan Carlos Quevedo-Abeledo, Vanesa Hernández-Hernández, Antonia de Vera-González, Alejandra González-Delgado, José A. García-Dopico, Miguel Á. González-Gay, Iván Ferraz-Amaro   +7 more
doaj   +2 more sources

A Review of free fatty acid-induced cell signaling, angiopoietin-like protein 4, and skeletal muscle differentiation [PDF]

Frontiers in Physiology, 2022
Postnatal skeletal muscle differentiation from quiescent satellite cells is a highly regulated process, although our understanding of the contribution of nutritional factors in myogenesis is limited. Free fatty acids (FFAs) are known to cause detrimental
Yura Son, Chad M. Paton, Chad M. Paton
doaj   +2 more sources

Kidney angiopoietin-like protein 4 regulates fibrotic responses in diabetic kidney disease [PDF]

Frontiers in Pharmacology
The angiopoietin-like (ANGPTL) proteins are now recognized as critical regulators of the harmful changes seen in diabetic kidney disease. Notably, a hyposialylated pro-proteinuric form of ANGPTL4 has been identified as a crucial contributor to fibrosis ...
Swayam Prakash Srivastava, Ajan Vishnu Arora, Mariam Hamed, Adesh Urval, Aashika Dupati, Shangyang Xia, Shota Yoshida, Ken Inoki, Ken Inoki, Ken Inoki   +9 more
doaj   +2 more sources

Angiopoietin-Like Protein 4 May Be an Interplay Between Serum Uric Acid and Triglyceride-Rich Lipoprotein Cholesterol [PDF]

Frontiers in Cardiovascular Medicine, 2022
BackgroundAlthough the available evidence has indicated a link between elevated serum uric acid (SUA) level and dyslipidemia, the potential contribution of SUA on lipid profiles remains unclear.
Yani Peng, Die Hu, Die Hu, Qingting Luo, Daoquan Peng, Daoquan Peng   +5 more
doaj   +2 more sources

The Relationship Between Plasma Angiopoietin-like Protein 4 Levels, Angiopoietin-like Protein 4 Genotype, and Coronary Heart Disease Risk [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2010
Objective— To investigate the relationship between angiopoietin-like protein 4 (Angptl4) levels, coronary heart disease (CHD) biomarkers, and ANGPTL4 variants. Methods and Results— Plasma Angptl4 was ...
Smart-Halajko, MC, Robciuc, MR, Cooper, JA, Jauhiainen, M, Kumari, M, Kivimaki, M, Khaw, KT, Boekholdt, SM, Wareham, NJ, Gaunt, TR, Day, IN, Braund, PS, Nelson, CP, Hall, AS, Samani, NJ, Humphries, SE, Ehnholm, C, Talmud, PJ   +17 more
openaire   +5 more sources

Serum Angiopoietin‐Like Protein 4 as a Biomarker for Acute Ischemic Stroke Severity and Dynamic Changes [PDF]

Brain and Behavior
Background Angiopoietin‐like protein 4 (ANGPTL4) is critical for vascular integrity and reducing inflammation in ischemic and hypoxic brain injuries. However, limited studies have evaluated ANGPTL4's role in acute ischemic stroke (AIS) assessment, and ...
Fang Guo, Chong Zheng, Tao Yang, Fang‐Wei Hu, Yan‐Gui Chen, Chia‐Wei Liou, Bin Cai   +6 more
doaj   +2 more sources

Decoding the role of angiopoietin-like protein 4/8 complex–mediated plasmin generation in the regulation of LPL activity [PDF]

Journal of Lipid Research, 2023
After feeding, adipose tissue lipoprotein lipase (LPL) activity should be maximized, therefore the potent LPL-inhibitory activity of angiopoietin-like protein 4 (ANGPTL4) must be blocked by ANGPTL8 through formation of ANGPTL4/8 complexes.
Yan Q. Chen, Eugene Y. Zhen, Anna M. Russell, Mariam Ehsani, Robert W. Siegel, Yuewei Qian, Robert J. Konrad   +6 more
doaj   +2 more sources

Overexpression of Angiopoietin-Like Protein 4 Protects Against Atherosclerosis Development [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2013
Objective— Macrophage foam cells play a crucial role in several pathologies including multiple sclerosis, glomerulosclerosis, and atherosclerosis. Angiopoietin-like protein 4 (Angptl4) was previously shown to inhibit chyle-induced foam cell formation in mesenteric lymph nodes.
Georgiadi, A., Wang, Y., Stienstra, R., Tjeerdema, N., Janssen, A., Stalenhoef, A., van der Vliet, A., de Roos, J.A., Tamsma, J.T., Smit, J.W., Tan, N.S., Müller, M.R., Rensen, P.C., Kersten, A.H.   +13 more
openaire   +7 more sources

Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 4 [PDF]

Journal of Lipid Research, 2004
Angiopoietin-like protein 4 (Angptl4) is the second member of the angiopoietin-like family of proteins previously shown to increase plasma triglyceride (TG) levels in vivo.
Hongfei Ge, Guoqing Yang, Xinxin Yu, Tiffany Pourbahrami, Cai Li   +4 more
doaj   +3 more sources

Skeletal Muscle Angiopoietin-Like Protein 4 and Glucose Metabolism in Older Adults after Exercise and Weight Loss [PDF]

Metabolites, 2020
Angiopoietin-like protein 4 (ANGPTL4) is an adipokine that plays an important role in energy homoeostasis and lipid and lipoprotein metabolism. This study was designed to determine the effect of an exercise plus weight loss intervention on ANGPTL4 ...
Guoyan Li, Hefang Zhang, Alice S. Ryan
doaj   +2 more sources