The role of Angiopoietin-like protein 4 in macrophage activation
, 2021 Angiopoietin-like protein 4 (Angptl4) is a matricellular protein that associates with extracellular matrix proteins, mediating complex cell-cell, and cell-matrix interactions.
Wee, Jonathan Wei Kiat
openaire +2 more sources
On the mechanism of angiopoietin-like protein 8 for control of lipoprotein lipase activity
Journal of Lipid Research, 2019 Angiopoietin-like (ANGPTL) 8 is a secreted inhibitor of LPL, a key enzyme in plasma triglyceride metabolism. It was previously reported that ANGPTL8 requires another member of the ANGPTL family, ANGPTL3, to act on LPL.
Oleg Kovrov +4 more
doaj +3 more sources
Lipopolysaccharide-induced podocyte injury is regulated by calcineurin/NFAT and TLR4/MyD88/NF-κB signaling pathways through angiopoietin-like protein 4 [PDF]
Genes and Diseases, 2022 Podocyte injury is an important cause of proteinuria. Angiopoietin-like protein 4 (Angptl4) is a secreted glycoprotein and has a role in proteinuria. However, the exact role of Angptl4 in podocyte injury and its upstream regulators has not been clarified.
Xiujin Shen +9 more
doaj +2 more sources
Angiopoietin-like protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMP [PDF]
Molecular Metabolism, 2017 Objective: Angiopoietin-like protein-4 (ANGPTL4) is a circulating protein that is highly expressed in liver and implicated in regulation of plasma triglyceride levels.
Bodil Ingerslev +10 more
doaj +2 more sources
Elevated Plasma Angiopoietin-like 4 Protein Levels in Adult Patients with Dengue
VirusesDengue virus infection can cause severe complications due to vascular leakage. Angiopoietin-like protein 4 (ANGPTL4) regulates vascular permeability, but its role in dengue pathogenesis is unclear.
Win Khaing +9 more
doaj +3 more sources
A randomised, controlled, crossover study of the effect of diet on angiopoietin-like protein 4 (ANGPTL4) through modification of the gut microbiome [PDF]
Journal of Nutritional Science, 2016 Angiopoietin-like protein 4 (ANGPTL4) is a lipoprotein lipase inhibitor that is involved in lipid metabolism and angiogenesis. Animal studies have suggested that the ANGPTL4 protein is modulated by the gut microbiota, possibly through increased ...
Trine Blædel +9 more
doaj +2 more sources
Differential regulation and properties of angiopoietin-like proteins 3 and 4 [PDF]
Journal of Lipid Research, 2005 Angiopoietin-like protein 3 and 4 (Angptl3 and Angptl4) are two members of the angiopoietin-like family of proteins. These two closely related proteins have been reported to similarly affect lipid metabolism through their capacity to inhibit lipoprotein ...
Hongfei Ge +6 more
doaj +3 more sources
Angiopoietin-like protein 4 (ANGPTL4) is an inhibitor of endothelial lipase (EL) while the ANGPTL4/8 complex has reduced EL-inhibitory activity. [PDF]
Heliyon, 2021 Chen YQ +5 more
europepmc +2 more sources
Prediction of Angiopoietin-like Protein 4-related Signaling Pathways in Cholangiocarcinoma Cells. [PDF]
Cancer Genomics Proteomics, 2022 Angiopoietin-like protein 4 (ANGPTL4) is a multifunctional signaling protein implicated in carbohydrate metabolism, inflammation, cancer growth and progression, anoikis resistance, angiogenesis, and metastasis. However, signaling pathways of ANGPTL4 in cholangiocarcinoma (CCA) remain unknown.
Aung TM +6 more
europepmc +3 more sources
The Journal of biological chemistry, 2013 Elevated triglycerides are associated with an increased risk of cardiovascular disease, and lipoprotein lipase (LPL) is the rate-limiting enzyme for the hydrolysis of triglycerides from circulating lipoproteins. The N-terminal domain of angiopoietin-like protein 4 (ANGPTL4) inhibits LPL activity.
Michael J, Lafferty +3 more
openaire +4 more sources