Results 51 to 60 of about 34,611,146 (146)

An orally active formulation of angiotensin-(1-7) produces an antithrombotic effect

Clinics, 2011
INTRODUCTION AND OBJECTIVE: The heptapeptide angiotensin-(1-7) is a component of the renin-angiotensin system, which promotes many beneficial cardiovascular effects, including antithrombotic activity. We have recently shown that the antithrombotic effect
Rodrigo Araujo Fraga-Silva, Fabiana P. Costa-Fraga, Frederico B. De Sousa, Natalia Alenina, Michael Bader, Ruben D. Sinisterra, Robson A. S. Santos   +6 more
doaj   +1 more source

Alamandine reduces leptin expression through the c-Src/p38 MAP kinase pathway in adipose tissue. [PDF]

PLoS ONE, 2017
Obesity is associated with an increased risk of diabetes mellitus, hypertension, and renal dysfunction. Angiotensin 1-7 and alamandine are heptameric renin angiotensin system peptide hormones.
Tsuyoshi Uchiyama, Fumikazu Okajima, Chihiro Mogi, Ayaka Tobo, Shoichi Tomono, Koichi Sato   +5 more
doaj   +1 more source

Regulation of the renal proximal tubule second sodium pump by angiotensins

Brazilian Journal of Medical and Biological Research, 2001
For several years it was believed that angiotensin II (Ang II) alone mediated the effects of the renin-angiotensin system. However, it has been observed that other peptides of this system, such as angiotensin-(1-7) (Ang-(1-7)), present biological ...
C. Caruso-Neves, L.B.A. Rangel, L.S. Lara, A.G. Lopes   +3 more
doaj   +1 more source

Evaluation of analgesic activity of perindopril in albino mice

Journal of Advanced Pharmaceutical Technology & Research, 2014
The aim was to evaluate the analgesic activity of perindopril in chemical, thermal and mechanical pain on Swiss albino mice. A total of 54 albino mice (Swiss strain) weighing 25-30 g were allocated to each experimental model and in each model there were ...
R N Suresha, Siddamma Amoghimath, P S Vaibhavi, S L Shruthi, M K Jayanthi, H L Kalabharathi   +5 more
doaj   +1 more source

Novel Insights into the Cardioprotective Effects of the Peptides of the Counter-Regulatory Renin–Angiotensin System

Biomedicines
Currently, cardiovascular diseases are a major contributor to morbidity and mortality worldwide, having a significant negative impact on both the economy and public health.
Janette Alejandra Gamiño-Gutiérrez, Ivana María Terán-Hernández, Jairo Castellar-Lopez, Wendy Villamizar-Villamizar, Estefanie Osorio-Llanes, Mariali Palacios-Cruz, Wendy Rosales, Aileen Y. Chang, Luis Antonio Díaz-Ariza, María Clara Ospino, Evelyn Mendoza-Torres   +10 more
doaj   +1 more source

Enhanced expression of Ang-(1-7) during pregnancy

Brazilian Journal of Medical and Biological Research, 2004
Pregnancy is a physiological condition characterized by a progressive increase of the different components of the renin-angiotensin system (RAS). The physiological consequences of the stimulated RAS in normal pregnancy are incompletely understood, and ...
Brosnihan K.B., Neves L.A.A., Anton L., Joyner J., Valdes G., Merrill D.C.   +5 more
doaj  

Modulation of the renin-angiotensin system against COVID-19: A path forward?

International Journal of Infectious Diseases
Soon after the pandemic outbreak in 2020, it was proposed that binding of SARS-CoV-2 to the angiotensin converting enzyme-2 may explain most of COVID-19’s manifestations.
Serge Camelo, Waly Dioh, J. Pedro Teixeira, Laurence W. Busse, Girish Nair, Gaëtan Plantefeve, Capucine Morelot-Panzini, Suzana Margareth Lobo, Wesley H. Self, Sean P. Collins, Rob Van Maanen, Stanislas Veillet   +11 more
doaj   +1 more source

Effect of Melatonin on the Renin-Angiotensin-Aldosterone System in l-NAME-Induced Hypertension

Molecules, 2018
The renin-angiotensin-aldosterone system (RAAS) is a dominant player in several cardiovascular pathologies. This study investigated whether alterations induced by l-NAME, (NLG)-nitro-l-arginine methyl ester, a nitric oxide synthase inhibitor, and the ...
Fedor Simko, Tomas Baka, Kristina Krajcirovicova, Kristina Repova, Silvia Aziriova, Stefan Zorad, Marko Poglitsch, Michaela Adamcova, Russel J. Reiter, Ludovit Paulis   +9 more
doaj   +1 more source

Angiotensin-(1-7) with Thioether Bridge: An Angiotensin-Converting Enzyme-Resistant, Potent Angiotensin-(1-7) Analog

, 2009
The in vivo efficacy of many therapeutic peptides is hampered by their rapid proteolytic degradation. Cyclization of these therapeutic peptides is an excellent way to render them more resistant against breakdown.
Walther, Thomas, de Vries, Louwe, Rink, Rick, Moll, Gert N., Kuipers, Anneke, Nelemans, S. Adriaan, Kluskens, Leon D., Meter-Arkema, Anita, Wang, Yong, Haas, Marijke   +9 more
core   +1 more source

Peran Angiotensin 1-7 pada Penyakit Ginjal Kronik

Jurnal Ilmu Kesehatan Indonesia
Latar Belakang:  Penyakit ginjal kronik (PGK) ditandai penurunan progresif fungsi ginjal. Pada patogenesisnya, sistem renin–angiotensin–aldosteron (RAAS) berperan sentral.
Dinda Putri Sofiani, Harnavi Harun
doaj   +1 more source