Results 31 to 40 of about 311,072 (299)
Hypertension, 2014 In the last decade, a substantial change in our understanding of the renin–angiotensin system (RAS) occurred.1,2 It is now clear that the circulating and tissue RAS are far more complex than previously anticipated. The modern concept of the RAS includes, in addition to the classical components (renin, angiotensin [Ang]-converting enzyme [ACE], Ang II ...
openaire +2 more sources
Adenoviral delivery of angiotensin-(1-7) or angiotensin-(1-9) inhibits cardiomyocyte hypertrophy via the mas or angiotensin Type 2 receptor [PDF]
, 2012 The counter-regulatory axis of the renin angiotensin system peptide angiotensin-(1-7) [Ang-(1-7)] has been identified as a potential therapeutic target in cardiac remodelling, acting via the mas receptor.
Nicklin Stuart A. +11 more
core +1 more source
Natriuretic action of angiotensin(1–7) [PDF]
British Journal of Pharmacology, 1994 Evidence that angiotensin (1–7) (Ang(1–7)) is biologically active and can be synthesized by the kidney prompted us to examine its actions in the rat, isolated kidney. Ang(1–7) had three major effects producing, (1) a substantial natriuresis and diuresis, (2) an increase in urinary sodium concentration associated with a fall in potassium concentration ...
A M, DelliPizzi +2 more
openaire +2 more sources
Electronic sculpting of ligand-GPCR subtype selectivity:the case of angiotensin II [PDF]
, 2014 GPCR subtypes possess distinct functional and pharmacological profiles, and thus development of subtype-selective ligands has immense therapeutic potential.
Pappas, Charalampos G. +41 more
core +1 more source
Journal of Veterinary Internal Medicine, 2021 Background The pathophysiology of heart failure involves maladaptive angiotensin peptides (APs) and enzymes, including angiotensin 2 (AT2) and angiotensin converting enzyme (ACE), as well as recently described alternative components, such as angiotensin ...
Éva Larouche‐Lebel +3 more
doaj +1 more source
Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy [PDF]
, 2007 Maternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor and placental growth factor.
Kellems, Rodney E. +19 more
core +1 more source
Neural Regeneration Research, 2022 Abnormal accumulation of α-synuclein contributes to the formation of Lewy bodies in the substantia nigra, which is considered the typical pathological hallmark of Parkinson’s disease.
Qing Gao +6 more
doaj +1 more source
Renin-Angiotensin System: A Review of Historical Perspectives
Galician Medical Journal, 2023 The article is a review of publications concerning historical perspectives of the renin-angiotensin system. The discovery of its components is presented in chronological order, beginning with the initial identification of renin and proceeding to the ...
Olga Kovalyova +2 more
doaj +1 more source
Intensive Care Medicine Experimental, 2019 Background Ventilator-induced diaphragmatic dysfunction (VIDD) is a common event during mechanical ventilation (MV) leading to rapid muscular atrophy and contractile dysfunction. Recent data show that renin-angiotensin system is involved in diaphragmatic
Vanessa Zambelli +7 more
doaj +1 more source
The Role of Renin–Angiotensin System in Diabetic Cardiomyopathy: A Narrative Review
Life, 2023 Diabetic cardiomyopathy refers to myocardial dysfunction in type 2 diabetes, but without the traditional cardiovascular risk factors or overt clinical atherosclerosis and valvular disease.
João Pedro Thimotheo Batista +3 more
doaj +1 more source