Results 61 to 70 of about 4,825,321 (354)

Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin.

Journal of Clinical Investigation, 2002
Renin is an aspartyl protease essential for the control of blood pressure and was long suspected to have cellular receptors. We report the expression cloning of the human renin receptor complementary DNA encoding a 350-amino acid protein with a single ...
G. Nguyen, F. Delarue, C. Burcklé, L. Bouzhir, T. Giller, J. Sraer   +5 more
semanticscholar   +1 more source

Semaphorin 3E‐Plexin‐D1 Pathway Downstream of the Luteinizing Hormone Surge Regulates Ovulation, Granulosa Cell Luteinization, and Ovarian Angiogenesis in Mice

Advanced Science, EarlyView.
The Semaphorin 3E (Sema3E)‐Plexin‐D1 pathway mediated by C/EBPα and C/EBPβ downstream of the luteinizing hormone (LH) surge plays important roles in the mouse preovulatory ovary. Timely activation and suppression of this pathway during the preovulatory stage are crucial for ovulation, corpus luteum formation, and proper angiogenesis.
Hanxue Zhang, Jimmy Dhillon, Paul D. Soloway, Bo Shui, Seoyeon Lee, Jennifer K. Grenier, Paul R. Munn, M. Cecilia Ljungberg, Rebecca B Williams, Rainer B. Lanz, Yu‐Hsiang Liao, Yi A. Ren   +11 more
wiley   +1 more source

Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension

Emerging Microbes and Infections, 2020
The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers
J. Meng, Guohui Xiao, Juanjuan Zhang, Xing He, M. Ou, Jing Bi, Rongqing Yang, Wencheng Di, Zhaoqin Wang, Zigang Li, Hong-yu Gao, Lei Liu, Guoliang Zhang   +12 more
semanticscholar   +1 more source

Delivery of Molecular Hydrogen for Precision Immunomodulation: Mechanisms, Detection Methods, and Applications

Advanced Science, EarlyView.
This review focuses on the immunomodulatory mechanisms of molecular hydrogen, the recent detection methods, and the classification advanced molecular hydrogen delivery materials. It provides a detailed description of their applications in areas such as arthritis, chronic wounds, cardiovascular injury, tumors, and bacterial infections, aiming to enhance
Gangfeng Li, Hannan Cui, Ruixiao Fan, Guming Liu, Zishuo Hou, Yibo Zhang, Xuanming Che, Tengjiao Wang, Hongbo Wei, Peng Li   +9 more
wiley   +1 more source

Angiotensin II Directly Increases Endothelial Calcium and Nitric Oxide in Kidney and Brain Microvessels In Vivo With Reduced Efficacy in Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The vasoconstrictor effects of angiotensin II via type 1 angiotensin II receptors in vascular smooth muscle cells are well established, but the direct effects of angiotensin II on vascular endothelial cells (VECs) in vivo and the mechanisms ...
Alejandra Becerra Calderon, Urvi Nikhil Shroff, Sachin Deepak, Audrey Izuhara, Greta Trogen, Alicia A. McDonough, Susan B. Gurley, Jonathan W. Nelson, János Peti‐Peterdi, Georgina Gyarmati   +9 more
doaj   +1 more source

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

Angiotensin II induces cholesterol accumulation and impairs insulin secretion by regulating ABCA1 in beta cells

Journal of Lipid Research, 2018
In pancreatic β cells, ABCA1, a 254 kDa membrane protein, affects cholesterol homeostasis and insulin secretion. Angiotensin II, as the main effector of the renin–angiotensin system, decreases glucose-stimulated insulin secretion (GSIS).
Jingya Lyu, Hitomi Imachi, Kensaku Fukunaga, Seisuke Sato, Tomohiro Ibata, Toshihiro Kobayashi, Tao Dong, Takuo Yoshimoto, Kazuko Yonezaki, Hiromi Nagata, Hisakazu Iwama, Koji Murao   +11 more
doaj  

Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients

Nature Communications, 2014
A novel influenza A (H7N9) virus of avian origin emerged in eastern China in the spring of 2013. This virus causes severe disease in humans, including acute and often lethal respiratory failure. As of January 2014, 275 cases of H7N9-infected patients had
Fengming Huang, Jing Guo, Zhen Zou, Jun Liu, B. Cao, Shuyang Zhang, Hui Li, Wei Wang, Miaomiao Sheng, Song Liu, Jingcao Pan, C. Bao, M. Zeng, Haixia Xiao, Guirong Qian, Xinjun Hu, Yuanting Chen, Yu Chen, Yan Zhao, Qiang Liu, Huandi Zhou, Jindong Zhu, Hainv Gao, Shigui Yang, Xiaoli Liu, Shufa Zheng, Jiezuan Yang, H. Diao, H. Cao, Ying Wu, Min Zhao, Shuguang Tan, D. Guo, Xiliang Zhao, Y. Ye, Wei Wu, Yingchun Xu, J. Penninger, Dangsheng Li, G. Gao, Chengyu Jiang, Lanjuan Li   +41 more
semanticscholar   +1 more source

Angiotensin-Converting Enzyme–Derived Angiotensin II Formation During Angiotensin II–Induced Hypertension [PDF]

Hypertension, 2009
The extent to which endogenous angiotensin (Ang) II formation is responsible for increasing kidney Ang II content and blood pressure during Ang II–induced hypertension is unknown. To address this, mice were treated with an Ang-converting enzyme (ACE) inhibitor (ACEi) to block endogenous Ang II formation during chronic Ang II infusions ...
Romer A. Gonzalez-Villalobos, Akemi Katsurada, Gabriel L. Navar, Hiroyuki Kobori, Laura Semprun-Prieto, Ryousuke Satou, Dale M. Seth   +6 more
openaire   +3 more sources

Leptin Aggravates Thoracic Aortic Dissection Through Impairment of Energy Metabolism in Nrip2+ Smooth Muscle Cells

Advanced Science, EarlyView.
Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen, Yujie Zhu, Xi Yang, JiangBin Wu, Keyuan Chen, Wuqing Huang, Lu Fang, Qi Zhang, Jie Chen, Jianing Gao, Huanhuan Cao, Meifang Wu, Zhihuang Qiu, Yuling Zhang, Yue Shen, Qiuyu Huang, Zhiyong Lin, Lemin Zheng, Liangwan Chen   +18 more
wiley   +1 more source