Results 71 to 80 of about 4,861,792 (337)

Leptin Aggravates Thoracic Aortic Dissection Through Impairment of Energy Metabolism in Nrip2+ Smooth Muscle Cells

Advanced Science, EarlyView.
Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen, Yujie Zhu, Xi Yang, JiangBin Wu, Keyuan Chen, Wuqing Huang, Lu Fang, Qi Zhang, Jie Chen, Jianing Gao, Huanhuan Cao, Meifang Wu, Zhihuang Qiu, Yuling Zhang, Yue Shen, Qiuyu Huang, Zhiyong Lin, Lemin Zheng, Liangwan Chen   +18 more
wiley   +1 more source

Multiple Mechanisms for the Action of Chymase Inhibitors

Journal of Pharmacological Sciences, 2012
Angiotensin II plays an important role in regulating blood pressure. Moreover, angiotensin II directly promotes organ damage by inducing expression of various genes, such as transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-9 ...
Shinji Takai, Denan Jin, Mizuo Miyazaki
doaj   +1 more source

The NADPH Oxidase Isoform 1 Contributes to Angiotensin II-Mediated DNA Damage in the Kidney

Antioxidants, 2020
In higher concentrations, the blood pressure regulating hormone angiotensin II leads to vasoconstriction, hypertension, and oxidative stress by activating NADPH oxidases which are a major enzymatic source of reactive oxygen species (ROS).
Anna Zimnol, Nora Spicker, Ronja Balhorn, Katrin Schröder, Nicole Schupp   +4 more
doaj   +1 more source

Angiotensin II plasma levels are linked to disease severity and predict fatal outcomes in H7N9-infected patients

Nature Communications, 2014
A novel influenza A (H7N9) virus of avian origin emerged in eastern China in the spring of 2013. This virus causes severe disease in humans, including acute and often lethal respiratory failure. As of January 2014, 275 cases of H7N9-infected patients had
Fengming Huang, Jing Guo, Zhen Zou, Jun Liu, B. Cao, Shuyang Zhang, Hui Li, Wei Wang, Miaomiao Sheng, Song Liu, Jingcao Pan, C. Bao, M. Zeng, Haixia Xiao, Guirong Qian, Xinjun Hu, Yuanting Chen, Yu Chen, Yan Zhao, Qiang Liu, Huandi Zhou, Jindong Zhu, Hainv Gao, Shigui Yang, Xiaoli Liu, Shufa Zheng, Jiezuan Yang, H. Diao, H. Cao, Ying Wu, Min Zhao, Shuguang Tan, D. Guo, Xiliang Zhao, Y. Ye, Wei Wu, Yingchun Xu, J. Penninger, Dangsheng Li, G. Gao, Chengyu Jiang, Lanjuan Li   +41 more
semanticscholar   +1 more source

The half‐lives of angiotensin II, angiotensin II‐amide, angiotensin III, Sar1‐Ala8‐angiotensin II and renin in the circulatory system of the rat.

The Journal of Physiology, 1978
1. Methods are described for estimating the half‐life of angiotensin analogues and renin in the rat, from the time course of the blood pressure changes they evoke. 2. The following half‐life values were measured: angiotensin II, 16 +/‐ 1 sec; angiotensin III, 14 +/‐ 1 sec; angiotensin II‐amide, 15 +/‐ 1 sec; Sar1‐Ala8‐angiotensin II, 6.4 +/‐ 0.6 min ...
Brooks Dp, S A Al-Merani, Kenneth A. Munday, Chapman Bj   +3 more
openaire   +4 more sources

Angiotensin-Converting Enzyme–Derived Angiotensin II Formation During Angiotensin II–Induced Hypertension [PDF]

Hypertension, 2009
The extent to which endogenous angiotensin (Ang) II formation is responsible for increasing kidney Ang II content and blood pressure during Ang II–induced hypertension is unknown. To address this, mice were treated with an Ang-converting enzyme (ACE) inhibitor (ACEi) to block endogenous Ang II formation during chronic Ang II infusions ...
Romer A. Gonzalez-Villalobos, Akemi Katsurada, Gabriel L. Navar, Hiroyuki Kobori, Laura Semprun-Prieto, Ryousuke Satou, Dale M. Seth   +6 more
openaire   +3 more sources

Mesencephalic Astrocyte‐Derived Neurotrophic Factor Binds BAX to Preserve Mitochondrial Homeostasis and Energy Metabolism for Relieving Myocardial Hypertrophy

Advanced Science, EarlyView.
MANF in cardiomyocytes interacts with BAX to impede BAX mitochondrial translocation and cytochrome c release, further stabilizing mitochondrial structure and energy supply to relieve myocardial apoptosis and hypertrophy, which indicates MANF as a novel cardioprotective factor to have a promising clinical application for myocardial hypertrophy ...
Dong Wang, Xinru Zhang, Baolong Wang, Haipeng Li, Dongshuo Xu, Yun Yang, Jialu Zhang, Wenbing Wang, Ren Zhang, Xinyu Wang, Yunfeng Cai, Shiyu Cao, Chao Hou, Changhui Wang   +13 more
wiley   +1 more source

Statin treatment in hypercholesterolemic men does not attenuate angiotensin II-induced venoconstriction. [PDF]

PLoS ONE, 2014
Experimental studies suggested that statins attenuate vascular AT1 receptor responsiveness. Moreover, the augmented excessive pressor response to systemic angiotensin II infusions in hypercholesterolemic patients was normalized with statin treatment.
Christoph Schindler, Kristina Guenther, Cosima Hermann, Carlos M Ferrario, Christoph Schroeder, Sven Haufe, Jens Jordan, Wilhelm Kirch   +7 more
doaj   +1 more source

Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade [PDF]

Journal of Human Hypertension, 2006
Angiotensin II (Ang II) increases adhesion molecules, cytokines and chemokines and exerts a proinflammatory effect on leucocytes, endothelial cells and vascular smooth muscle cells. Acting via the type 1 receptor, Ang II initiates an inflammatory cascade of reduced nicotinamide-adenine dinucleotide phosphate oxidase, reactive oxygen species (ROS) and ...
Sandeep Dhindsa, Paresh Dandona, Ajay Chaudhuri, Husam Ghanim   +3 more
openaire   +2 more sources

Oxytocin Reduces Subjective Fear in Naturalistic Social Contexts via Enhancing Top‐Down Middle Cingulate Amygdala Regulation and Brain‐Wide Fear Representations

Advanced Science, EarlyView.
This double‐blind, placebo‐controlled study demonstrates that intranasal oxytocin reduces subjective fear in immersive, naturalistic social (but not non‐social) contexts. Concomitant fMRI reveals that oxytocin enhances middle cingulate activity and amygdala connectivity while it modulates network‐level connectivity and attenuates reactivity of a brain ...
Kun Fu, Shuyue Xu, Zheng Zhang, Dan Liu, Ting Xu, Yuan Zhang, Feng Zhou, Xiaodong Zhang, Chunmei Lan, Junjie Wang, Lan Wang, Jingxian He, Keith M Kendrick, Bharat Biswal, Dezhong Yao, Zhen Liang, Weihua Zhao, Benjamin Becker   +17 more
wiley   +1 more source