Results 71 to 80 of about 5,061,790 (379)
Zebrafish Model to Study Angiotensin II-Mediated Pathophysiology
Biology, 2021 Hypertension, a common chronic condition, may damage multiple organs, including the kidney, heart, and brain. Thus, it is essential to understand the pathology upon ectopic activation of the molecular pathways involved in mammalian hypertension to ...
Bhagyashri Joshi +3 more
doaj +1 more source
Modeling the molecular impact of SARS-CoV-2 infection on the renin-angiotensin system [PDF]
arXiv, 2020 SARS-CoV-2 coronavirus infection is mediated by the binding of its spike protein to the angiotensin-converting enzyme 2 (ACE2), which plays a pivotal role in the renin-angiotensin system (RAS). The study of RAS dysregulation due to SARS-CoV-2 infection is fundamentally important for a better understanding of the pathogenic mechanisms and risk factors ...
arxiv
Angiotensin-neprilysin inhibition versus enalapril in heart failure.
New England Journal of Medicine, 2014 BACKGROUND We compared the angiotensin receptor-neprilysin inhibitor LCZ696 with enalapril in patients who had heart failure with a reduced ejection fraction. In previous studies, enalapril improved survival in such patients.
J. McMurray +10 more
semanticscholar +1 more source
Advanced Sensor Research, EarlyView.A one‐step electrochemical strategy is utilized to develop a flexible, enzyme‐free biosensor for the sensitive detection of uric acid (UA). The hierarchical cobalt nanostructures synergistically enhance the performance of the biosensor, resulting in a broad detection range of 5 to 700 µM with a sensitivity of 6.75 µA µM−1 cm−2 and a low detection limit
Anju Joshi, Gymama Slaughter
wiley +1 more source
Hypertension regulating angiotensin peptides in the pathobiology of cardiovascular disease
Clinical and Experimental Hypertension, 2018 Renin angiotensin system (RAS) is an endogenous hormone system involved in the control of blood pressure and fluid volume. Dysregulation of RAS has a pathological role in causing cardiovascular diseases through hypertension.
Misbah Hussain, Fazli Rabbi Awan
doaj +1 more source
Low Dose Chronic Angiotensin II Induces Selective Senescence of Kidney Endothelial Cells
Frontiers in Cell and Developmental Biology, 2021 Angiotensin II can cause oxidative stress and increased blood pressure that result in long term cardiovascular pathologies. Here we evaluated the contribution of cellular senescence to the effect of chronic exposure to low dose angiotensin II in a model ...
Irfan Khan +10 more
doaj +1 more source
A computational insight of the improved nicotine binding with ACE2-SARS-CoV-2 complex with its clinical impact [PDF]
arXiv, 2020 Smokers being witnessed with the mild adverse clinical symptoms of SARS-CoV-2, the in-silico study is intended to explore the effect of nicotine binding to the soluble angiotensin converting enzyme II (ACE2) receptor with or without SARS-CoV-2 binding.
arxiv
Modulation of angiotensin II signaling in the prevention of fibrosis
Fibrogenesis & Tissue Repair, 2015 Over the last decade, it has become clear that the role of angiotensin II extends far beyond recognized renal and cardiovascular effects. The presence of an autologous renin-angiotensin system has been demonstrated in almost all tissues of the body.
A. Murphy, A. Wong, M. Bezuhly
semanticscholar +1 more source
Angiotensin-(1-7) increases osmotic water permeability in isolated toad skin [PDF]
, 2000 Angiotensin-(1-7) (Ang-(1-7)) increased osmotic water permeability in the isolated toad skin, a tissue with functional properties similar to those of the distal mammalian nephron. Concentrations of 0.1 to 10 μM were effective, with a peak at 20 min. This
Coviello, Alfredo +3 more
core +4 more sources
Advanced Science, EarlyView.In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang +10 more
wiley +1 more source