Results 71 to 80 of about 262,681 (286)

Predictors and morphological properties of culprit healed plaques in patients with angina pectoris

Clinical Cardiology, Volume 45, Issue 12, Page 1199-1210, December 2022., 2022
Abstract Background Plaque healing may serve a vital function in the natural progression of atherosclerotic disease. This study sought to investigate predictors and morphological characteristics of healed plaque (HP) among angina pectoris (AP) patients.
Hongying Yao, Qianyun Guo, Yujing Cheng, Tianyu Zhu, Qian Ma, Yujie Zhou   +5 more
wiley   +1 more source

Analysis of the Vasorelaxant Action of Angiotensin II in the Isolated Rat Renal Artery

Journal of Pharmacological Sciences, 2008
Taking into consideration that mechanisms involved in the vasodilatator actions of angiotensin II have not yet been completely elucidated, the present study was undertaken in order to examine the mechanisms underlying the angiotensin II–induced ...
Leposava Grbović, Jelena Djokić, Miroslav Radenković, Srðan Pešic   +3 more
doaj  

The NADPH Oxidase Isoform 1 Contributes to Angiotensin II-Mediated DNA Damage in the Kidney

Antioxidants, 2020
In higher concentrations, the blood pressure regulating hormone angiotensin II leads to vasoconstriction, hypertension, and oxidative stress by activating NADPH oxidases which are a major enzymatic source of reactive oxygen species (ROS).
Anna Zimnol, Nora Spicker, Ronja Balhorn, Katrin Schröder, Nicole Schupp   +4 more
doaj   +1 more source

Mapping active allosteric loci SARS-CoV Spike Proteins by means of Protein Contact Networks [PDF]

arXiv, 2020
Coronaviruses are a class of virus responsible of the recent outbreak of Human Severe Acute Respiratory Syndrome. The molecular machinery behind the viral entry and thus infectivity is based on the formation of the complex of virus spike protein with the angiotensin-converting enzyme 2 (ACE2).
arxiv  

Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade [PDF]

Journal of Human Hypertension, 2006
Angiotensin II (Ang II) increases adhesion molecules, cytokines and chemokines and exerts a proinflammatory effect on leucocytes, endothelial cells and vascular smooth muscle cells. Acting via the type 1 receptor, Ang II initiates an inflammatory cascade of reduced nicotinamide-adenine dinucleotide phosphate oxidase, reactive oxygen species (ROS) and ...
Sandeep Dhindsa, Paresh Dandona, Ajay Chaudhuri, Husam Ghanim   +3 more
openaire   +2 more sources

Decoding Blastocystis‐Driven Mechanisms in Gut Microbiota and Host Metabolism

Advanced Science, EarlyView.
Blastocystis, a prevalent gut microbe, interacts with the host through metabolic and immune pathways, influencing cardiometabolic health. This perspective explores its role in modulating short‐chain fatty acid production, tryptophan metabolism, and immune signaling, potentially impacting cholesterol absorption, glucose metabolism, and vascular health ...
Lei Deng, Kevin SW Tan
wiley   +1 more source

Survival benefit of overweight patients undergoing MitraClip® procedure in comparison to normal‐weight patients

Clinical Cardiology, Volume 45, Issue 12, Page 1236-1245, December 2022., 2022
Long‐term survival stratified for weight classes illustrated by Hazard plot for patients treated with MitraClip® implantation stratified for weight classes. Association of weight class compared to normal‐weight with long‐term survival (adjusted for Logistic EuroScore).
Karsten Keller, Martin Geyer, Lukas Hobohm, Alexander R. Tamm, Felix Kreidel, Tobias F. Ruf, Michaela Hell, Volker H. Schmitt, Kevin Bachmann, Sonja Born, Eberhard Schulz, Thomas Münzel, Ralph S. von Bardeleben   +12 more
wiley   +1 more source

Angiotensin II induces cholesterol accumulation and impairs insulin secretion by regulating ABCA1 in beta cells

Journal of Lipid Research, 2018
In pancreatic β cells, ABCA1, a 254 kDa membrane protein, affects cholesterol homeostasis and insulin secretion. Angiotensin II, as the main effector of the renin–angiotensin system, decreases glucose-stimulated insulin secretion (GSIS).
Jingya Lyu, Hitomi Imachi, Kensaku Fukunaga, Seisuke Sato, Tomohiro Ibata, Toshihiro Kobayashi, Tao Dong, Takuo Yoshimoto, Kazuko Yonezaki, Hiromi Nagata, Hisakazu Iwama, Koji Murao   +11 more
doaj  

The half‐lives of angiotensin II, angiotensin II‐amide, angiotensin III, Sar1‐Ala8‐angiotensin II and renin in the circulatory system of the rat.

The Journal of Physiology, 1978
1. Methods are described for estimating the half‐life of angiotensin analogues and renin in the rat, from the time course of the blood pressure changes they evoke. 2. The following half‐life values were measured: angiotensin II, 16 +/‐ 1 sec; angiotensin III, 14 +/‐ 1 sec; angiotensin II‐amide, 15 +/‐ 1 sec; Sar1‐Ala8‐angiotensin II, 6.4 +/‐ 0.6 min ...
Brooks Dp, S A Al-Merani, Kenneth A. Munday, Chapman Bj   +3 more
openaire   +4 more sources

CNPY2 Aggravates Renal Tubular Cell Ferroptosis in Diabetic Nephropathy by Regulating PERK/ATF4/CHAC1 Pathway and MAM Integrity

Advanced Science, EarlyView.
Canopy FGF signaling regulator 2 (CNPY2) which is contributed to ERS is upregulated in the renal tubules of patients with diabetic nephropathy (DN). Mechanistically, CNPY2 may regulate ferroptosis and MAM integrity in renal tubular epithelial cells through PERK/ATF4/CHAC1 pathway, thereby promoting the progression of DN.
Jingfang Chen, Dongwei Liu, Lei Lei, Ting Liu, Shaokang Pan, Hui Wang, Yong Liu, Yingjin Qiao, Zhangsuo Liu, Qi Feng   +9 more
wiley   +1 more source