Results 71 to 80 of about 4,825,321 (354)
Angiotensin II and inflammation: the effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockade [PDF]
Journal of Human Hypertension, 2006 Angiotensin II (Ang II) increases adhesion molecules, cytokines and chemokines and exerts a proinflammatory effect on leucocytes, endothelial cells and vascular smooth muscle cells. Acting via the type 1 receptor, Ang II initiates an inflammatory cascade of reduced nicotinamide-adenine dinucleotide phosphate oxidase, reactive oxygen species (ROS) and ...
Sandeep Dhindsa +3 more
openaire +2 more sources
Advanced Science, EarlyView.Abnormal mechanical stretch induced by mechanical ventilation (MV) disrupts endothelial junctions via the NOX2/ROS/CaMKII/ERK1/2 axis both in human aortic endothelial cells (HAECs) in vitro and in ventilator‐induced lung injury (VILI) in mice. Quercetin, an antioxidant predicted to bind to NOX2, can effectively prevent mechanical stretch‐induced ...
Tao Jiang +8 more
wiley +1 more source
Analysis of the Vasorelaxant Action of Angiotensin II in the Isolated Rat Renal Artery
Journal of Pharmacological Sciences, 2008 Taking into consideration that mechanisms involved in the vasodilatator actions of angiotensin II have not yet been completely elucidated, the present study was undertaken in order to examine the mechanisms underlying the angiotensin II–induced ...
Leposava Grbović +3 more
doaj
Intrarenal Angiotensin II Augmentation in Angiotensin II Dependent Hypertension.
Hypertension Research, 2000 In several models of angiotensin II (ANG II) dependent hypertension, intrarenal ANG II levels increase to a much greater extent than the circulating levels even though the renal renin levels are decreased. The 2-kidney-1-clip (2K1C) Goldblatt rat model is particularly intriguing because hypertension develops in the presence of an intact kidney which ...
L. Gabriel Navar +1 more
openaire +3 more sources
Advanced Science, EarlyView.This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai +9 more
wiley +1 more source
Effect of Angiotensin II on Blood Flow in Acute and Chronically Inflamed Knee Joints of Rabbits: The Role of Nitric Oxide [PDF]
Iranian Journal of Medical Sciences, 2009 Background: Angiotensin converting enzyme (ACE) upregulationin stromal cells of joints affected by rheumatoid arthritismay lead to higher tissue angiotensin II that is a vasoconstrictorand mitogen factor.
Hamid Najafipour +3 more
doaj
Angiotensin II and Renal Tubular Ion Transport
The Scientific World Journal, 2005 Angiotensin II, a potent vasoconstrictor, also participates in the regulation of renal sodium and water excretion, not only via a myriad of effects on renal hemodynamics, glomerular filtration rate, and regulation of aldosterone secretion, but also via ...
Patricia Valles +2 more
doaj +1 more source
The NADPH Oxidase Isoform 1 Contributes to Angiotensin II-Mediated DNA Damage in the Kidney
Antioxidants, 2020 In higher concentrations, the blood pressure regulating hormone angiotensin II leads to vasoconstriction, hypertension, and oxidative stress by activating NADPH oxidases which are a major enzymatic source of reactive oxygen species (ROS).
Anna Zimnol +4 more
doaj +1 more source
ACE2: Angiotensin II/Angiotensin-(1–7) Balance in Cardiac and Renal Injury
Current Hypertension Reports, 2014 Our current recognition of the renin-angiotensin system is more convoluted than originally thought due to the discovery of multiple novel enzymes, peptides, and receptors inherent in this interactive biochemical cascade. Over the last decade, angiotensin-
J. Varagić +3 more
semanticscholar +1 more source
The Journal of Physiology, 1978 1. Methods are described for estimating the half‐life of angiotensin analogues and renin in the rat, from the time course of the blood pressure changes they evoke. 2. The following half‐life values were measured: angiotensin II, 16 +/‐ 1 sec; angiotensin III, 14 +/‐ 1 sec; angiotensin II‐amide, 15 +/‐ 1 sec; Sar1‐Ala8‐angiotensin II, 6.4 +/‐ 0.6 min ...
Brooks Dp +3 more
openaire +4 more sources