Results 21 to 30 of about 272,686 (351)

Angiotensin II type 1 and type 2 receptor expression in circulating monocytes of diabetic and hypercholesterolemic patients over 3-month rosuvastatin treatment

Cardiovascular Diabetology, 2012
Background In diabetes, a variety of pro-inflammatory cellular changes has been found in various cell types, including monocytes which are known to be involved in all the phases of atherogenesis.
Marino Franca, Maresca Andrea Maria, Cosentino Marco, Castiglioni Luana, Rasini Emanuela, Mongiardi Christian, Maio Ramona C, Legnaro Massimiliano, Schembri Laura, Dentali Francesco, Grandi Anna Maria, Guasti Luigina   +11 more
doaj   +1 more source

ANGIOTENSIN II RECEPTOR TYPE 1 EXPRESSION IN PATIENTS WITH MULTIFOCAL ATHEROSCLEROSIS

Российский кардиологический журнал, 2016
Local expression of rennin-angiotensin system (RAS) components significantly increases in patients with arterial hypertension and atherosclerosis with or without elevation of RAS activity in the blood.
I. S. Mykhailichenko
doaj   +1 more source

Functional selectivity profiling of the angiotensin II type 1 receptor using pathway-wide BRET signaling sensors

Science Signaling, 2018
Bioluminescence-based biosensors enable comprehensive profiling of G protein–coupled receptor signaling bias. Biosensors for GPCR-biased signaling Upon binding to ligands, G protein–coupled receptors (GPCRs) stimulate heterotrimeric G proteins and ...
Y. Namkung, Christian LeGouill, Sahil Kumar, Yubo Cao, Larissa B. Teixeira, V. Lukasheva, Jenna Giubilaro, S. C. Simões, Jean-Michel Longpré, D. Devost, T. Hébert, G. Piñeyro, R. Leduc, C. Costa-Neto, M. Bouvier, S. Laporte   +15 more
semanticscholar   +1 more source

Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet [PDF]

, 2017
AIM:To determine the effect of tempol in normal rats fed high salt on arterial pressure and the balance between antagonist components of the renal renin-angiotensin system.METHODS:Sprague-Dawley rats were fed with 8% NaCl high-salt (HS) or 0.4% NaCl ...
Cao, Gabriel Fernando, Choi, Marcelo Roberto, Della Penna, Silvana Lorena, Fernandez, Belisario Enrique, Gorzalczany, Susana Beatriz, Kouyoumdzian, Nicolás Martín, Roson, Maria Ines, Toblli, Jorge Eduardo   +7 more
core   +1 more source

Enhancement of Adipocyte Browning by Angiotensin II Type 1 Receptor Blockade. [PDF]

PLoS ONE, 2016
Browning of white adipose tissue (WAT) has been highlighted as a new possible therapeutic target for obesity, diabetes and lipid metabolic disorders, because WAT browning could increase energy expenditure and reduce adiposity.
Kana Tsukuda, Masaki Mogi, Jun Iwanami, Harumi Kanno, Hirotomo Nakaoka, Xiao-Li Wang, Hui-Yu Bai, Bao-Shuai Shan, Masayoshi Kukida, Akinori Higaki, Toshifumi Yamauchi, Li-Juan Min, Masatsugu Horiuchi   +12 more
doaj   +1 more source

Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure. Role of kinins and angiotensin II type 2 receptors.

Journal of Clinical Investigation, 1997
Angiotensin-converting enzyme inhibitors (ACEi) improve cardiac function and remodeling and prolong survival in patients with heart failure (HF). Blockade of the renin-angiotensin system (RAS) with an angiotensin II type 1 receptor antagonist (AT1-ant ...
Y. H. Liu, X. Yang, Victor G. Sharov, O. Nass, H. Sabbah, E. Peterson, O. Carretero   +6 more
semanticscholar   +1 more source

Angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade prevent cardiac remodeling in pigs after myocardial infarction: role of tissue angiotensin II [PDF]

, 2000
BACKGROUND: The mechanisms behind the beneficial effects of renin-angiotensin system blockade after myocardial infarction (MI) are not fully elucidated but may include interference with tissue angiotensin II (Ang II).
Boomsma, F. (Frans), Danser, A.H.J. (Jan), Duncker, D.J.G.M. (Dirk), Haitsma, D.B. (David), Kats, J.P. (Sjors) van, Niebuur, R., Schalekamp, M.A.D.H. (Maarten), Schuijt, M.P., Stubenitsky, R. (René), Verdouw, P.D. (Pieter)   +9 more
core   +1 more source

Hypertension: Renin-Angiotensin-Aldosterone System Alterations [PDF]

, 2015
Blockers of the renin-angiotensin-aldosterone system (RAAS), that is, renin inhibitors, angiotensin (Ang)-converting enzyme (ACE) inhibitors, Ang II type 1 receptor antagonists, and mineralocorticoid receptor antagonists, are a cornerstone in the ...
Danser, A.H.J. (Jan), Esch, J.H.M. (Joep) van, Meiracker, A.H. (Anton) van den, Riet, L. (Luuk) te, Roks, A.J.M. (Anton)   +4 more
core   +1 more source

Angiotensin II Type 1 Receptor Gene Regulation [PDF]

Hypertension, 2007
Angiotensin II (Ang II), the major bioactive peptide of the renin–angiotensin system, was originally described as a potent vasoconstrictor. It is now recognized as a multifunctional hormone influencing many cellular processes, including cell growth, apoptosis, migration, inflammation, and fibrosis.1,2 Under pathological conditions, the vasoconstrictor,
Terry S, Elton, Mickey M, Martin
openaire   +2 more sources

Mechanisms With Clinical Implications for Atrial Fibrillation–Associated Remodeling: Cathepsin K Expression, Regulation, and Therapeutic Target and Biomarker [PDF]

, 2014
Background: The cysteine protease cathepsin K (CatK) has been implicated in the pathogenesis of cardiovascular disease. We sought to determine the link between atrial fibrillation (AF) and plasma CatK levels and to investigate the expression of and ...
Cheng, Xian Wu, Fujita, Masaya, Inden, Yasuya, Inoue, Aiko, Kuzuya, Masafumi, Kyo, Seifuku, Murohara, Toyoaki, Okumura, Kenji, Shi, Guo‐Ping, Shimano, Masayuki, Taguchi, Noriko, Takeshita, Kyosuke, Yamamoto, Toshihiko, Yoshida, Naoki   +13 more
core   +1 more source