Tacrolimus Induced Hypertension and Vascular Remodeling Includes Mechanisms of Cellular Senescence-The Protective Effect of Valsartan. [PDF]
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Effect of SGLT2 Inhibitors on Atrial Fibrillation in Patients With Type 2 Diabetes With Dilated Cardiomyopathy: A Cohort Study. [PDF]
Wang J, Qi S, Chen S, Yu H.
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Incidence and outcomes of diabetes mellitus amongst hospital admissions with <i>de novo</i> heart failure; a retrospective cohort study from a nationwide registry. [PDF]
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The angiotensin II type 1 receptor blocker valsartan attenuates graft vasculopathy
Basic Research in Cardiology, 2004Transplant arteriosclerosis remains the major cause of graft failure after cardiac transplantation. Here, we investigated the effects of the angiotensin II type 1 receptor blocker valsartan on the development of transplant arteriosclerosis in a murine model of cardiac transplantation.Hearts from DBA/2 (H-2(d)) mice were heterotopically transplanted ...
Tetsufumi, Yamamoto +3 more
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Abstract: Renin‐angiotensin system blockade retards the progression of diabetic and non‐diabetic chronic kidney disease of the native kidneys. Though most patients suffer from a significant renal insufficiency (chronic kidney disease stage III) and a concomitant heart disease after renal transplantation, there is up to now no evidence supporting the ...
C, Morath +12 more
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Effect of angiotensin II type 1 receptor blocker on osteoporotic rat femurs
Pharmacological Reports, 2012Osteoblasts and osteoclasts are known to express Ang II type I (AT1) receptor in cell cultures, suggesting the existence of local renin-angiotensin system (RAS) in bone. This study was designed to investigate the effects of losartan as AT1 receptor blocker on ovariectomized rats' femur.Losartan (5 mg/kg/day) was administered via oral gavage for 8 weeks.
Ozdemir S. +7 more
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Class- and Molecule-specific Differential Effects of Angiotensin II Type 1 Receptor Blockers
Current Pharmaceutical Design, 2013Angiotensin II (Ang II) type 1 (AT1) receptor is a member of the G protein-coupled receptor superfamily and contains 359 amino acids. AT1 receptor blockers (ARBs, e.g., eprosartan, losartan, candesartan, valsartan, telmisartan, olmesartan, irbesartan, and azilsartan) have been developed and are available for clinical use, and basic and clinical studies
Satoshi, Imaizumi +5 more
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The angiotensin II receptor blockers (ARBs) are safe and effective agents in the treatment of hypertension, and they have potential in treating other cardiovascular disorders such as heart failure. These drugs share a common mechanism of action: They selectively block the angiotensin type 1 (AT1) receptor.
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Possible benefits of azilsartan compared with other angiotensin II type 1 receptor blockers
Hypertension Research, 2014Possible benefits of azilsartan compared with other angiotensin II type 1 receptor ...
Shin-Ichiro, Miura, Keijiro, Saku
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