Angiotensin II type 2 receptor (AT2R) as a novel modulator of inflammation in rheumatoid arthritis synovium. [PDF]
Sci Rep, 2017 Despite increasing evidence suggesting that angiotensin II type 2 receptor (AT2R) may regulate tissue inflammation, no study has yet analyzed its possible implication in rheumatoid arthritis (RA) synovitis.
Terenzi R +7 more
europepmc +4 more sources
Neuroprotective effect of angiotensin II type 2 receptor during cerebral ischemia/reperfusion [PDF]
Neural Regeneration Research, 2016 Angiotensin II type 2 receptor (AT2R) activation has been shown to protect against stroke, but its precise mechanism remains poorly understood. We investigated whether the protective effect of AT2R against ischemia/reperfusion injury is mediated by the ...
Chun-ye Ma, Lin Yin
doaj +3 more sources
Angiotensin II Type 2 Receptor: A Target for Protection Against Hypertension, Metabolic Dysfunction, and Organ Remodeling. [PDF]
Hypertension, 2021 The renin-angiotensin system is of vital significance not only in the maintenance of blood pressure but also because of its role in the pathophysiology of different organ systems in the body.
Fatima N, Patel SN, Hussain T.
europepmc +2 more sources
Novel Pharmacology Following Heteromerization of the Angiotensin II Type 2 Receptor and the Bradykinin Type 2 Receptor [PDF]
Frontiers in Endocrinology, 2022 The angiotensin type 2 (AT2) receptor and the bradykinin type 2 (B2) receptor are G protein-coupled receptors (GPCRs) that have major roles in the cardiovascular system. The two receptors are known to functionally interact at various levels, and there is
Elizabeth K. M. Johnstone +15 more
doaj +2 more sources
Angiotensin II type 2 receptor–interacting protein 3a inhibits ovarian carcinoma metastasis via the extracellular HMGA2-mediated ERK/EMT pathway [PDF]
Tumor Biology, 2017 Local migration and long-distance metastasis is the main reason for higher mortality of ovarian cancer. Microtubule-associated tumor suppressor 1/angiotensin II type 2 receptor–interacting protein is associated with tumor initiation and progression and ...
Ping Huang +3 more
doaj +2 more sources
Macrophage angiotensin II type 2 receptor triggers neuropathic pain. [PDF]
Proc Natl Acad Sci U S A, 2018 Significance Neuropathic pain is a widespread problem that is undermanaged by currently available analgesic drugs. An antagonist of the type II angiotensin II receptor (AT2R) reduces pain behaviors related to neuropathy, suggesting that angiotensin ...
Shepherd AJ +10 more
europepmc +2 more sources
Beneficial Effect of Mas Receptor Deficiency on Vascular Cognitive Impairment in the Presence of Angiotensin II Type 2 Receptor [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018 BackgroundThe classical renin‐angiotensin system is known as the angiotensin (Ang)‐converting enzyme/Ang II/Ang type 1 receptor axis, which induces various organ damage including cognitive decline.
Akinori Higaki +12 more
doaj +2 more sources
Loss of Angiotensin II Type 2 Receptor Improves Blood Pressure in Elastin Insufficiency [PDF]
Frontiers in Cardiovascular Medicine, 2021 There is ample evidence supporting a role for angiotensin II type 2 receptor (AT2R) in counterbalancing the effects of angiotensin II (ang II) through the angiotensin II type 1 receptor by promoting vasodilation and having anti-inflammatory effects ...
Michelle Lin +4 more
doaj +2 more sources
The angiotensin II receptors type 1 and 2 modulate astrocytes and their crosstalk with microglia and neurons in an in vitro model of ischemic stroke [PDF]
BMC NeuroscienceBackground Astrocytes are the most abundant cell type of the central nervous system and are fundamentally involved in homeostasis, neuroprotection, and synaptic plasticity.
Daniel Navin Olschewski +12 more
doaj +2 more sources
Potential nephroprotective effects of angiotensin II type 2 receptor agonist Compound 21 in renal ischemia-reperfusion injury. [PDF]
J Med Life, 2023 Kadhim LF +4 more
europepmc +2 more sources