Results 51 to 60 of about 74,786 (193)

Dissociation between the circulating renin-angiotensin system and angiotensin II receptors in central losartan-induced hypertension

Brazilian Journal of Medical and Biological Research, 2002
Losartan, an AT1 angiotensin II (ANG II) receptor non-peptide antagonist, induces an increase in mean arterial pressure (MAP) when injected intracerebroventricularly (icv) into rats.
A.M. Sugawara, R.C. Vendramini, S.P. Barbosa, I.L. Brunetti, J.V. Menani, L.A. De Luca Jr.   +5 more
doaj   +1 more source

Novel Therapies for Alport Syndrome

Frontiers in Medicine, 2022
Alport syndrome (AS) is a hereditary kidney disease associated with proteinuria, hematuria and progressive kidney failure. It is characterized by a defective glomerular basement membrane caused by mutations in type IV collagen genes COL4A3/A4/A5 which ...
Efren Chavez, Juanly Rodriguez, Yelena Drexler, Alessia Fornoni, Alessia Fornoni   +4 more
doaj   +1 more source

Interplay between brain stem angiotensins and monocyte chemoattractant protein-1 as a novel mechanism for pressor response after ischemic stroke

Neurobiology of Disease, 2014
Pressor response after stroke commonly leads to early death or susceptibility to stroke recurrence, and detailed mechanisms are still lacking. We assessed the hypothesis that the renin–angiotensin system contributes to pressor response after stroke by ...
Alice Y.W. Chang, Faith C.H. Li, Chi-Wei Huang, Julie C.C. Wu, Kuang-Yu Dai, Chang-Han Chen, Shau-Hsuan Li, Chia-Hao Su, Re-Wen Wu   +8 more
doaj   +1 more source

Is There an Interplay Between the Functional Domains of IRAP?

Frontiers in Cell and Developmental Biology, 2020
As a member of the M1 family of aminopeptidases, insulin regulated aminopeptidase (IRAP) is characterized by distinct binding motifs at the active site in the C-terminal domain that mediate the catalysis of peptide substrates.
Anika Vear, Tracey Gaspari, Philip Thompson, Siew Yeen Chai   +3 more
doaj   +1 more source

The Replacement of His(4) in Angiotensin IV by Conformationally Constrained Residues Provides Highly Potent and Selective Analogues

, 2016
The histidine residue in angiotensin IV was replaced by various conformationally constrained amino acids. The substitution of the His4−Pro5 dipeptide sequence by the constrained Trp analogue Aia−Gly, in combination with β2hVal substitution at the N ...
Patrick Vanderheyden (2136151), Aneta Lukaszuk (2348398), Debby Feytens (1352310), Heidi Demaegdt (470499), Dirk Tourwé (1314852), Georges Vauquelin (2136157)   +5 more
core   +1 more source

Effect of furosemide on comprehensive renin‐angiotensin‐aldosterone system activity of Thoroughbred horses

Journal of Veterinary Internal Medicine
Background Furosemide, a commonly used diuretic, activates the renin‐angiotensin‐aldosterone system (RAAS) in other species. Little is known about RAAS peptide activation in horses.
Mallory L. Lehman, Oliver Domenig, Marisa K. Ames, Jessica M. Morgan   +3 more
doaj   +1 more source

Sacubitril/Valsartanstive Heart Failure: Cardiogenic Shock

Case Reports in Cardiology, 2018
Sacubitril/valsartan is a combination drug described as a new class of dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for heart failure.
H. A. Rawal, A. G. Kocheril
doaj   +1 more source

Severe Epistaxis after Tissue Plasminogen Activator administration for Acute Ischemic Stroke in SARS-COV-2 Infection

Brain Circulation, 2021
Patients with COVID-19 may suffer from hemorrhagic complications. Our article highlights two cases of COVID-19-infected patients, who suffered severe epistaxis after initiation of intravenous recombinant tissue plasminogen activator (IV-rtPA) for acute ...
Priyank Khandelwal, Enrique Martínez-Pías, Ivo Bach, Tannavi Prakash, Machteld E Hillen, Mario Martínez-Galdámez, Juan F Arenillas   +6 more
doaj   +1 more source

Angiotensin IV and the human esophageal mucosa: An exploratory study in healthy subjects and gastroesophageal reflux disease patients

, 2014
The human esophageal mucosa expresses various components of the renin-angiotensin system (RAS), e.g. the main effector peptide angiotensin II (AngII).
Edebo, Anders,, Anna Casselbrant, Fändriks, Lars,, Björkman, Eleonora,, Anders Edebo, Casselbrant, Anna,, Lars Fändriks, Eleonora Björkman   +7 more
core   +1 more source

Evaluation of the multifunctional dipeptidyl-peptidase IV and angiotensin converting enzyme inhibitory properties of a casein hydrolysate using cell-free and cell-based assays

Frontiers in Nutrition, 2023
The objective of the study was the evaluation of the potential pleiotropic effect of a commercial casein hydrolysate (CH). After an analysis of the composition, the BIOPEP-UWM database suggested that these peptides contained numerous sequences with ...
Jianqiang Li, Carlotta Bollati, Gilda Aiello, Martina Bartolomei, Fabrizio Rivardo, Giovanna Boschin, Anna Arnoldi, Carmen Lammi   +7 more
doaj   +1 more source