Results 61 to 70 of about 74,786 (193)

H(2)S inhibits hyperglycemia-induced intrarenal renin-angiotensin system activation via attenuation of reactive oxygen species generation. [PDF]

PLoS ONE, 2013
Decrease in endogenous hydrogen sulfide (H2S) was reported to participate in the pathogenesis of diabetic nephropathy (DN). This study is aimed at exploring the relationship between the abnormalities in H2S metabolism, hyperglycemia-induced oxidative ...
Hong Xue, Ping Yuan, Jun Ni, Chen Li, Decui Shao, Jia Liu, Yang Shen, Zhen Wang, Li Zhou, Wei Zhang, Yu Huang, Chen Yu, Rui Wang, Limin Lu   +13 more
doaj   +1 more source

Acute AT1 receptor blockade does not improve the depressed baroreflex in rats with chronic renal hypertension

Brazilian Journal of Medical and Biological Research, 2000
To assess the role of angiotensin II in the sensitivity of the baroreflex control of heart rate (HR) in normotensive rats (N = 6) and chronically hypertensive rats (1K1C, 2 months, N = 7), reflex changes of HR were evaluated before and after (15 min) the
V.M.A. Farah, E.D. Moreira, M. Ushizima, I.A. Cestari, M.C. Irigoyen, E.M. Krieger   +5 more
doaj   +1 more source

Clinical features of angioedema induced by renin-angiotensin-aldosterone system inhibition: a retrospective analysis of 84 patients

Journal of Community Hospital Internal Medicine Perspectives, 2019
Background and objectives: Bradykinin-mediated angioedema (AE) induced by antihypertensive drugs primarily affect the head and neck region and may occur even after several years of uneventful treatment. Many facts about the clinical course remain unknown.
Anja Pfaue, Patrick J. Schuler, Benjamin Mayer, Thomas K. Hoffmann, Jens Greve, Janina Hahn   +5 more
doaj   +1 more source

Angiotensin IV is induced in experimental autoimmune encephalomyelitis but fails to influence the disease

, 2014
In multiple sclerosis (MS) and its corresponding animal models, over-activity of the renin-angiotensin system (RAS) has been reported and pharmacological RAS blockade exerts beneficial effects.
Kovacs, A., Poglitsch, M., Manzel, A., Domenig, O., Gold, R., Linker, R.A., Stegbauer, J., Mueller, D.N., Ambrosius, B.   +8 more
core   +1 more source

Evidence for angiotensin IV receptors in human collecting duct cells

, 1996
Evidence for angiotensin IV receptors in human collecting duct cells. Because angiotensin II (Ang II) has been found at high concentrations in the proximal tubule fluid and because tubular brush border membranes exhibit a marked capacity for degrading ...
Chansel, Dominique, Vandermeersch, Sophie, Ronco, Pierre, Ardaillou, Raymond, Czekalski, Stanislas   +4 more
core   +1 more source

Evaluation of Angiotensin IV Analogue Effects Mediated by the Hepatocyte Growth Factor and c-Met System

, 2011
Angiotensin IV (VYIHPF) is a peptide that binds to the AT4 receptor in the brain and periphery to mediate its actions which include: depression, regulation of cerebral blood flow, cerebroprotection and regulation of fluid homeostasis, hormonal balance ...
Benoist, Caroline
core   +1 more source

Therapeutic effects of astragaloside IV on myocardial injuries: multi-target identification and network analysis.

PLoS ONE, 2012
Astragaloside IV (AGS-IV) is a main active ingredient of Astragalus membranaceus Bunge, a medicinal herb used for cardiovascular diseases (CVD). In this work, we investigated the therapeutic mechanisms of AGS-IV at a network level by computer-assisted ...
Jing Zhao, Pengyuan Yang, Fan Li, Lin Tao, Hong Ding, Yaocheng Rui, Zhiwei Cao, Weidong Zhang   +7 more
doaj   +1 more source

Intracerebroventricular administrations of angiotensin IV (Ang IV) ameliorate cognitive disorder in diabetic rats

, 2013
Cognitive impairment is a common complication of diabetes. Hippocampus plays an important role in cognitive function. In hyperglycemia, synaptophysin, a crucial synaptic vesicle membrane protein in hippocampus neuron is found to be down-regulated. Recent
Siti Ayuni Binti Zakyudin
core  

Involvement of the somatostatin 2 receptor in the anticonvulsant effect of angiotensin IV against pilocarpine-induced limbic seizures in rats

, 2006
The anti-convulsant properties of angiotensin IV (Ang IV), an inhibitor of insulin-regulated aminopeptidase (IRAP) and somatostatin-14, a substrate of IRAP, were evaluated in the acute pilocarpine rat seizure model.
De Bundel, Dimitri, Ebinger, Guy, Stragier, B, Smolders, I, Stragier, Bart, Clinckers, R, Ebinger, G, Sarre, S, Smolders, Ilse, Clinckers, Ralph, Meurs, Alfred, De Bundel, D, Michotte, Yvette, Michotte, Y, Sarre, Sophie   +14 more
core   +1 more source

Angiotensin IV induced contractions in human jejunal wall musculature in vitro [Elektronisk resurs]

, 2014
Angiotensin II (AngII) has been reported to mediate contractile actions in rats and human jejunal wall musculature. However, except for one report showing the Angiotensin IV (AngIV) contractile effects on the internal anal sphincter of rats, no data is ...
Edgaras, Stankevičius, Mantas, Malinauskas,, Casselbrant, Anna,   +2 more
core   +1 more source