Results 71 to 80 of about 74,786 (193)

Contributions of the Brain Angiotensin IV–AT₄Receptor Subtype System to Spatial Learning

, 1999
The development of navigational strategies to solve spatial problems appears to be dependent on an intact hippocampal formation. The circular water maze task requires the animal to use extramaze spatial cues to locate a pedestal positioned just below the
Eric S. Pederson, Joseph W. Harding, LeighAnn Stubley, John W. Wright, Enikö A. Kramár, Jodi M. Hanesworth   +5 more
core   +1 more source

Cognitive Effects Attributed to Angiotensin II may Result from its Conversion to Angiotensin IV

Journal of the Renin-Angiotensin-Aldosterone System, 2006
This study tests the hypothesis that the facilitation of learning and improvement of memory observed after an intracerebroventricular (i.c.v.) injection of angiotensin II (Ang II) is, in fact, caused by its derivative angiotensin IV (Ang IV). We ran two memory tests as well as an auxiliary test assessing motor performance in rats injected (i.c.v., 1 ...
Jan Jozef, Braszko, Anna, Walesiuk, Przemyslaw, Wielgat   +2 more
openaire   +2 more sources

Angiotensin IV induces tyrosine phosphorylation of focal adhesion kinase and paxillin in proximal tubule cells

, 2001
Angiotensin IV (ANG IV), the COOH-terminal hexapeptide fragment of angiotensin II (ANG II), binds to specific sites in the kidney, distinct from type 1 (AT1) and type 2 (AT2) receptors and designated type 4 (AT4) receptors.
Raymond C. Harris, Jian-Kang Chen, Kevin D. Burns, Joe Zimpelmann   +3 more
core   +1 more source

Angiotensin IV AT₄-receptor system in the rat kidney

, 1998
Angiotensin IV, {[des-Asp1,Arg2]ANG II or ANG-(3—8)}, has been shown to preferentially bind to a novel angiotensin binding site (AT4receptor). The cellular location and function of this receptor in the rat kidney is unknown.
Luke T. Krebs, Rajash K. Handa, Joseph W. Harding, Shelly E. Handa   +3 more
core   +1 more source

Small potent ligands to the insulin-regulated aminopeptidase (IRAP)/AT(4) receptor

, 2007
Angiotensin IV analogs encompassing aromatic scaffolds replacing parts of the backbone of angiotensin IV have been synthesized and evaluated in biological assays.
Axén, Andreas,, Karlén, Anders,, Andersson, Hanna,, Lindeberg, Gunnar,, Demaegdt, Heidi, Hallberg, Mathias,, Kortesmaa, Jarkko, Rönnholm, Harriet, Vauquelin, Georges   +8 more
core   +1 more source

Clinical and histopathological features of lupus nephritis and the risk of long-term kidney outcomes in Indonesia

Frontiers in Lupus
ObjectiveRace and region-specific variables influence lupus nephritis clinical features and prognosis. We examined the clinicopathological presentation and long-term kidney outcomes of lupus nephritis in Indonesia.MethodsThis was a retrospective cohort ...
Ni Made Hustrini, Ni Made Hustrini, Endang Susalit, Monik Ediana Miranda, Meilania Saraswati, Y. K. Onno Teng, Merel van Diepen, Joris I. Rotmans   +7 more
doaj   +1 more source

Continuous Infusion of Angiotensin IV Protects against Acute Myocardial Infarction via the Inhibition of Inflammation and Autophagy. [PDF]

Oxid Med Cell Longev, 2021
Bai WW, Wang H, Gao CH, Liu KY, Guo BX, Jiang F, Zhang MX, Li C, Qin WD.   +8 more
europepmc   +1 more source

On the development of the Angiotensin IV ligands, Norleual and NLE -Angiotensin IV, as anti-cancer and wound healing agents

, 2008
Cancer and defective wound healing continue to be formidable clinical challenges accounting for billions of dollars in health care expenditures annually. Newly emerging treatment modalities for treating these diseases include the design and recombinant production of growth factors to promote wound healing and monoclonal antibodies to inhibit primary ...
openaire   +2 more sources

Decreased behavioural and neurochemical effects of angiotensin IV following prenatal alcohol exposure in the mouse

, 2019
Angiotensin IV (ang IV)is known to improve learning and memory in animal models but the mechanism is unclear. We have previously demonstrated sex differences in the pro-cognitive effects of ang IV, and that prenatal alcohol exposure (PAE)abolishes these ...
Fidalgo, Sara, Quadir, Angela, Gard, Paul, Sadiq, Wafia, Patel, Mira   +4 more
core   +1 more source

Angiotensin IV attenuates diabetic cardiomyopathy via suppressing FoxO1-induced excessive autophagy, apoptosis and fibrosis. [PDF]

Theranostics, 2021
Zhang M, Sui W, Xing Y, Cheng J, Cheng C, Xue F, Zhang J, Wang X, Zhang C, Hao P, Zhang Y.   +10 more
europepmc   +1 more source