Results 1 to 10 of about 1,867 (189)

Clinical Value of Circulating Angiopoietin-like Protein 8/Betatrophin Levels in Patients with Acute Pancreatitis [PDF]

Medicina
Background and Objectives: Acute pancreatitis (AP) is an inflammatory disorder of the pancreas, with severe cases linked to a higher mortality rate. The prognosis of AP is influenced by factors such as necrosis, secondary infections, and organ failure ...
Perihan Ozkan Gumuskaya, Emine Yildirim, Ozgur Altun, Hafize Uzun   +3 more
doaj   +5 more sources

ANGPTL8 in metabolic homeostasis: more friend than foe? [PDF]

Open Biology, 2021
ANGPTL8 is an important cytokine, which is significantly increased in type 2 diabetes mellitus (T2DM), obesity and metabolic syndrome. Many studies have shown that ANGPTL8 can be used as a bio-marker of these metabolic disorders related diseases, and the
Chang Guo, Chenxi Wang, Xia Deng, Jianqiang He, Ling Yang, Guoyue Yuan   +5 more
doaj   +3 more sources

Liver-specific expression of ANGPTL8 promotes Alzheimer’s disease progression through activating microglial pyroptosis [PDF]

Journal of Neuroinflammation
Introduction Liver dysfunction contributes to Alzheimer’s disease (AD) pathogenesis, and evidence suggests that the liver is involved in amyloid β (Aβ) clearance, and regulates Aβ deposition in the brain.
Jiarui Wei, Lin Hu, Shufan Xu, Fan Yang, Fusheng Liao, Ying Tang, Xin Shen, Xiaoqiao Zhang, Xinggang Fang, Yifan Li, Li Ding, Zhuo Chen, Shanchun Su, Junhua Cheng, Yong Huang, Qian Chen, Daqing Ma, Qiufang Zhang, Xingrong Guo   +18 more
doaj   +2 more sources

Inhibition of ANGPTL8 protects against diabetes-associated cognitive dysfunction by reducing synaptic loss via the PirB signaling pathway [PDF]

Journal of Neuroinflammation
Background Type 2 diabetes mellitus (T2D) is associated with an increased risk of cognitive dysfunction. Angiopoietin-like protein 8 (ANGPTL8) is an important regulator in T2D, but the role of ANGPTL8 in diabetes-associated cognitive dysfunction remains ...
Xiaoyu Meng, Danpei Li, Ranran Kan, Yuxi Xiang, Limeng Pan, Yaming Guo, Peng Yu, Peiqiong Luo, Huajie Zou, Li Huang, Yurong Zhu, Beibei Mao, Yi He, Lei Xie, Jialu Xu, Xiaoyan Liu, Wenjun Li, Yong Chen, Suiqiang Zhu, Yan Yang, Xuefeng Yu   +20 more
doaj   +2 more sources

Angiopoietin-like protein 8 orchestrates macrophage glycogen metabolism and polarization via the JNK signaling pathway in cytokine storm syndrome [PDF]

Cell & Bioscience
Cytokine storm syndrome (CSS) is associated with severe damage and high mortality in acute diseases. Over-activation of M1 macrophages, accompanied with excessive pro-inflammatory cytokine secretion, drives cytokine storms, while promoting M2 macrophage ...
Yang Su, Rongtian Zhang, Kongdong Li, Hong Shen, Mengjiao Nan, Chang Liu, Wenxiang Zhang, Siyu Chen   +7 more
doaj   +2 more sources

ANGPTL8 deficiency attenuates lipopolysaccharide-induced liver injury by improving lipid metabolic dysregulation [PDF]

Journal of Lipid Research
Liver injury is closely related to poor outcomes in sepsis patients. Current studies indicate that sepsis is accompanied by metabolic disorders, especially those related to lipid metabolism.
Ying Feng, Shan Luo, Chen Fang, Shinan Ma, Dandan Fan, Yanghui Chen, Zhuo Chen, Xiang Zheng, Yijun Tang, Xiaobei Duan, Xingling Liu, Xuzhi Ruan, Xingrong Guo   +12 more
doaj   +2 more sources

Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy. [PDF]

PLoS ONE, 2016
The β-cell mitogenic effects of ANGPTL8 have been subjected to substantial debate. The original findings suggested that ANGPTL8 overexpression in mice induced a 17-fold increase in β-cell proliferation.
Aaron R Cox, Ornella Barrandon, Erica P Cai, Jacqueline S Rios, Julia Chavez, Claire W Bonnyman, Carol J Lam, Peng Yi, Douglas A Melton, Jake A Kushner   +9 more
doaj   +6 more sources

ANGPTL8 accelerates liver fibrosis mediated by HFD-induced inflammatory activity via LILRB2/ERK signaling pathways

Journal of Advanced Research, 2023
Introduction: High calorie intake is known to induce nonalcoholic fatty liver disease (NAFLD) by promoting chronic inflammation. However, the mechanisms are poorly understood.
Zongli Zhang, Yue Yuan, Lin Hu, Jian Tang, Zhongji Meng, Longjun Dai, Yujiu Gao, Shinan Ma, Xiaoli Wang, Yahong Yuan, Qiufang Zhang, Weibin Cai, Xuzhi Ruan, Xingrong Guo   +13 more
doaj   +1 more source

ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease [PDF]

, 2021
Protein-truncating variants (PTVs) affecting dyslipidemia risk may point to therapeutic targets for cardiometabolic disease. Our objective was to identify PTVs that were associated with both lipid levels and the risk of coronary artery disease (CAD) or ...
Daly, Mark, Havulinna, Aki S., Helkkula, Pyry, Karjalainen, Juha, Kiiskinen, Tuomo, Koskinen, Seppo, Palotie, Aarno, Ripatti, Samuli, Salomaa, Veikko, Surakka, Ida   +9 more
core   +1 more source

Angiopoietin-like protein 8 promotes phenotypic transformation of rat aorta vascular smooth muscle cells [PDF]

Jichu yixue yu linchuang, 2022
Objective To explore the role and mechanism of angiopoietin-like protein 8 (ANGPTL8) on phenotypic transformation of rat aorta vascular smooth muscle cells (VSMCs).
SUN Qiu-ju, JIAO Xiao-lu, YU Hua-hui, LI Fan, LYU Qian-wen, WANG Yu, QIN Yan-wen
doaj   +1 more source