Results 91 to 100 of about 11,372 (280)

Antifungal Resistance in Non‐fumigatus Aspergillus Species

Mycoses, Volume 68, Issue 4, April 2025.
ABSTRACT This review provides an in‐depth exploration of antifungal resistance in non‐fumigatus Aspergillus species, mainly focusing on acquired resistance. The available data have been compiled and sometimes re‐analysed. It highlights the increasing prevalence of resistance in non‐fumigatus species belonging to Flavi, Terrei, Nigri, and Nidulantes ...
Elie Djenontin, Rose‐Anne Lavergne, Florent Morio, Eric Dannaoui   +3 more
wiley   +1 more source

Population Analysis of Anidulafungin in Infants to Older Adults With Confirmed or Suspected Invasive Candidiasis

Clinical pharmacology and therapy, 2020
In a pooled population analysis, we investigated the pharmacokinetics of i.v. anidulafungin in four studies across a full range of adult and pediatric ages in patients with confirmed, suspected, or at high risk of invasive candidiasis (IC). Relationships
R. Xie, L. Mcfadyen, S. Raber, R. Swanson, M. Tawadrous, H. Leister-Tebbe, M. Cohen-Wolkowiez, D. Benjamin, Ping Liu   +8 more
semanticscholar   +1 more source

Assessment of the feed additive consisting of Saccharomyces cerevisiae NCYC R404 for dairy cows for the renewal of its authorisation (Volac International Ltd)

EFSA Journal, Volume 23, Issue 4, April 2025.
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the assessment of the application for renewal of the authorisation of Saccharomyces cerevisiae NCYC R404 as a zootechnical additive (functional group: gut flora stabilisers) for dairy cows.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Ilen Röhe, Katerina Theodoridou, Andrey Yurkov, Montserrat Anguita, Nicole Bozzi Cionci, Rosella Brozzi, Yolanda García‐Cazorla, Jordi Tarrés‐Call, Piera Valeri, Matteo L. Innocenti   +24 more
wiley   +1 more source

In vitro synergy of echinocandins with triazoles against fluconazole-resistant Candida parapsilosis complex isolates

Journal of Global Antimicrobial Resistance, 2020
Introduction: Candida parapsilosis (C. parapsilosis) is a common non-albicans Candida species ranked as the second common cause of bloodstream infections. Azole resistance and elevated echinocandin MICs have been reported for these fungi.
Ali Ahmadi, Shahram Mahmoudi, Sassan Rezaie, Sayed Jamal Hashemi, Eric Dannaoui, Hamid Badali, Mansoureh Ghaffari, Farzad Aala, Alireza Izadi, Aida Maleki, Jacques F. Meis, Sadegh Khodavaisy   +11 more
doaj  

In vitro interaction of isavuconazole and anidulafungin against azole-susceptible and azole-resistant Aspergillus fumigatus isolates

Journal of Antimicrobial Chemotherapy, 2020
Background The voriconazole and echinocandin combination has been found to be synergistic in vitro and in vivo against most Aspergillus fumigatus isolates, both with a WT azole phenotype and an azole-resistant phenotype.
Jochem B. Buil, R. Brüggemann, L. Denardi, W. Melchers, P. Verweij   +4 more
semanticscholar   +1 more source

Pharmacokinetic/pharmacodynamic modelling approaches in paediatric infectious diseases and immunology. [PDF]

, 2014
Pharmacokinetic/pharmacodynamic (PKPD) modelling is used to describe and quantify dose-concentration-effect relationships. Within paediatric studies in infectious diseases and immunology these methods are often applied to developing guidance on ...
Abdel-Rahman, Ahsman, Ambrose, Anderson, Anderson, Anderson, Andes, Andes, Assael, Baley, Barclay, Barclay, Barlogis, Bartelink, Bayles, Benjamin, Benson, Berger, Bhandari, Blumer, Bomgaars, Bonate, Botha, Bouazza, Bradley, Buck, Burkhardt, Call, Charles, Charlotte I.S. Barker, Charrier, Chen, Clave, Cohen-Wolkowiez, Cohen-Wolkowiez, Committee, Craig, De Beaudrap, de Groot, de Hoog, de Hoog, de Hoog, de Repentigny, Doby, Doogue, Dowell, Downing, Driscoll, Driscoll, Drusano, Drylewicz, Du, Dudley, Duval, Elter, Englund, Ette, Ette, Ette, Eva Germovsek, Fallen, Fedele, Filler, Fletcher, Foot, Forrest, Frenkel, Friberg, Garcia, Garrido, Giannelli, Giuliano, Glowka, Gonzalez-Peralta, Grimsley, Groll, Groll, Guedj, Hassan, Hennig, Herbrecht, Hintz, Hong, Hope, Hope, Hope, Hope, Hosoya, Huenecke, Iida, Ikawa, Izquierdo, Jacqz-Aigrain, Jensen, Joanna Lewis, Jodi M. Lestner, Joseph F. Standing, Kafetzis, Karlsson, Kaufman, Kearns, Kelley, Kicklighter, Kim, Kimberlin, Kimberlin, Kimberlin, Knoderer, Koehl, Koenig, Kohli, Krakovska, Krishna, Lam, Lankester, Lavielle, Lee, Lee, Lestner, Lewis, Lewis, Lewis, Li, Li, Lodise, Louie, Luck, Lukas, Marques-Minana, McJunkin, Meszner, Mohamed, Moore, Muller, Muller, Neely, Neely, Nielsen, Ogungbenro, Ohata, Olkinuora, Oxford, Padari, Palumbo, Parker, Pascual, Payen, Perelson, Pescovitz, Pescovitz, Piper, Plunkett, Prague, Preston, Pullen, Putter, Rajagopalan, Renard, Rodriguez, Rodriguez-Tudela, Rollo L. Hoare, Rong, Rudd, Sabin, Saez-Llorens, Saez-Llorens, Salinger, Sardemann, Saxen, Schaefer, Schmitt, Schwinger, Seibel, Seidel, Sherwin, Smith, Standing, Starke, Sugaya, Sullender, Surh, Suyagh, Tamma, Tarral, Tasso, Tedeschi, Terragna, Thiebaut, Thiébaut R, Tod, Tod, Touw, Tulkens, van den Anker, van Hasselt, Vandecasteele, Vaudry, Vervelde, Vezina, Walsh, Waxman, Willemze, Wu, Wurthwein, Yoshizawa, Zeng, Zhang, Zhao, Zobell   +208 more
core   +1 more source

Humanized Candida and NanoBiT Assays Expedite Discovery of Bdf1 Bromodomain Inhibitors With Antifungal Potential

Advanced Science, Volume 12, Issue 10, March 13, 2025.
The fungal BET protein Bdf1 is a potential antifungal target in pathogenic Candida species requiring the inhibition of both its bromodomains. Humanized Candida strains and NanoBiT complementation assays developed to evaluate on‐target antifungal efficacy expedite the discovery of Bdf1 bromodomain inhibitors with antifungal potential, supporting BET ...
Kaiyao Wei, Marie Arlotto, Justin M. Overhulse, Tuan‐Anh Dinh, Yingsheng Zhou, Nathan J. Dupper, Jiayi Yang, Boris A. Kashemirov, Hasan Dawi, Cécile Garnaud, Gaëlle Bourgine, Flore Mietton, Morgane Champleboux, Amédé Larabi, Yordan Hayat, Rose‐Laure Indorato, Marjolaine Noirclerc‐Savoye, Dimitrios Skoufias, Muriel Cornet, Gwenaël Rabut, Charles E. McKenna, Carlo Petosa, Jérôme Govin   +22 more
wiley   +1 more source

Anidulafungin and Micafungin Concentrations in Cerebrospinal Fluid and in Cerebral Cortex

Antimicrobial Agents and Chemotherapy, 2020
Anidulafungin and micafungin were quantified in cerebrospinal fluid (CSF) of critically ill adults and in cerebral cortex of deceased patients. In CSF, anidulafungin levels (
J. Marx, R. Welte, Tiziana Gasperetti, P. Moser, R. Beer, M. Ortler, M. Jeske, R. Stern, A. Pomaroli, M. Joannidis, R. Bellmann   +10 more
semanticscholar   +1 more source

Living donor uterus transplant research project in Singapore: Progress of the first case

Acta Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 3, Page 548-558, March 2025.
Living Donor Uterus Transplant Research Project in Singapore: Progress of the First Case. Abstract Introduction To report the progress of the human living uterus transplant research project in Singapore. Material and Methods The uterus transplant research project began in 2012 with a collaboration between the Swedish and Singapore teams.
Hak Koon Tan, Terence Y. S. Kee, Bien Keem Tan, Pernilla Dahm‐Kähler, Niclas Kvarnström, Ravinchandran Nadarajah, Khong Yik Chew, Ban Hock Tan, Tew Hong Ho, Lay Kok Tan, Yin Ru Tan, Sobhana Thangaraju, Loong Tat Wong, John S. E. Lee, Leslie E. C. Lim, Shing Lih Wong, Lay Guat Ng, Yan Mee Law, Crystal Lim, Prema Raj Jeyaraj, Ruban Poopalingam, Mats Brännström   +21 more
wiley   +1 more source

Rapid automated antifungal susceptibility testing system for yeasts based on growth characteristics

Frontiers in Cellular and Infection Microbiology, 2023
Fungal pathogens are a major threat to public health, as they are becoming increasingly common and resistant to treatment, with only four classes of antifungal medicines currently available and few candidates in the clinical development pipeline.
Jinhan Yu, Jinhan Yu, Jinhan Yu, Chun He, Tong Wang, Tong Wang, Ge Zhang, Ge Zhang, Jin Li, Jin Li, Jingjia Zhang, Jingjia Zhang, Wei Kang, Wei Kang, Yingchun Xu, Yingchun Xu, Ying Zhao, Ying Zhao   +17 more
doaj   +1 more source