Results 51 to 60 of about 2,702,428 (250)

Verification and comparison of pig, mouse, and human genome similarities: use of manual assembly and analyses

BMC Genomics
Background Recently there have been numerous attempts to improve the genome of the pig. Despite these efforts, there is a substantial amount of work remaining to obtain a “finished version” of the genome; analysis of incomplete versions can lead to ...
Harry D. Dawson, Celine T. Chen, Jack S. Ragonese, Allen D. Smith, Joan K. Lunney   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The effects of L-carnitine and type of fat on carcass characteristics and immune response of broiler chickens [PDF]

Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, 2014
Two hundred and forty one-day-old male broilers (Ross-308) in 6 treatments with 4 replicates and 10 birds in each replicate were used in this experiment.
khosro Parsaeimehr, habib Cheraghi, saeid hosseinzade, mohammad Afrouziyeh, abbasali Ahmadie Naghdehi   +4 more
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Aglutenic cupcakes for gastro-intestinal symptoms and hematological indices in diagnosed celiac children –A randomized trialWhat is knownWhat is new

Clinical Nutrition Open Science
S U M M A R Y: Fundamental adherence to gluten-free diet can improve gastrointestinal symptoms. Substitution of wheat should be done in order to fulfil gluten-free criteria and nutrient density.
Shaista Jabeen, Azmat Ullah Khan
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Vegetarianism in the UK. [PDF]

The aim of this research is to develop an understanding of why people become vegetarian and why the diet is currently enjoying a steady increase in popularity in contemporary Britain, through addressing the 'hidden agenda' of vegetarianism ...
Draper, AK
core   +1 more source

Food Quality and Safety in Pakistan’s Agrifood Sector: A Review of Regulatory Frameworks, Innovation Diffusion, and Capacity-Building Priorities

Journal of Food Quality
This comprehensive review critically examines the current landscape of food quality and safety within the agrifood industry, with a particular emphasis on the Pakistani context.
Shahnai Basharat, Hafiza Madiha Jaffar, Muhammad Abdul Rahim, Fahad Al-Asmari, Mohamed Fawzy Ramadan, Eliasse Zongo   +5 more
doaj   +1 more source