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How open science can support the 3Rs and improve animal research [PDF]

Research Ideas and Outcomes, 2023
Open science in its broadest sense can make better science and provide benefits to researchers. When applied to animal experimentation, it can prevent unnecessary use of animals, because knowledge and experiences about past animal experimentation are ...
Monique Janssens, Stefan Gaillard, Judith de Haan, Wim de Leeuw, Matthew Brooke, Maura Burke, Jacques Flores, Iris Kruijen, Julia Menon, Adrian Smith, Ivo Tiebosch, Felix Weijdema   +11 more
doaj   +3 more sources

Investigating multi-material hydrogel three-dimensional printing for in vitro representation of the neo-vasculature of solid tumours: a comprehensive mechanical analysis and assessment of nitric oxide release from human umbilical vein endothelial cells

Royal Society Open Science, 2023
Many solid tumours (e.g. sarcoma, carcinoma and lymphoma) form a disorganized neo-vasculature that initiates uncontrolled vessel formation to support tumour growth.
Lisa Asciak, Lauren Gilmour, Jonathan A. Williams, Euan Foster, Lara Díaz-García, Christopher McCormick, James F. C. Windmill, Helen E. Mulvana, Joseph C. Jackson-Camargo, Roger Domingo-Roca   +9 more
doaj   +1 more source

Phase-In to Phase-Out—Targeted, Inclusive Strategies Are Needed to Enable Full Replacement of Animal Use in the European Union

Animals, 2022
In September 2021, the European Parliament voted overwhelmingly in favour of a resolution to phase out animal use for research, testing, and education, through the adoption of an action plan.
Lindsay J. Marshall, Helder Constantino, Troy Seidle   +2 more
doaj   +1 more source

The Case for Modernizing Biomedical Research in Ireland through the Creation of an Irish 3Rs Centre

Animals, 2022
Since its publication, the 3Rs principle has provided a cornerstone for more ethical and humane biomedical and regulatory research. In Europe, the 3Rs principle has been incorporated into the European Directive 63/2010/EU, with the ultimate aim of fully ...
Viola Galligioni, Dania Movia, Daniel Ruiz-Pérez, José Manuel Sánchez-Morgado, Adriele Prina-Mello   +4 more
doaj   +1 more source

Modernizing Medical Research to Benefit People and Animals

Animals, 2022
In the context of widespread public and political concern around the use of animals in research, we sought to examine the scientific, ethical and economic arguments around the replacement of animals with New Approach Methodologies (NAMs) and to situate ...
Isobel Hutchinson, Carla Owen, Jarrod Bailey   +2 more
doaj   +1 more source

ADVANCES IN VETERINARY EDUCATION THROUGH NON-ANIMAL MODELS [PDF]

Trakia Journal of Sciences, 2022
PURPOSE: With the recognition of animals as sentient beings and the growing research in the field of animal welfare the use of live animals for scientific purposes and education has been under question.
S. Woolcock, Iv. Lazarova
doaj   +1 more source

An anatomically correct 3D‐printed mouse phantom for magnetic particle imaging studies

Bioengineering & Translational Medicine, 2022
We report anatomically correct 3D‐printed mouse phantoms that can be used to plan experiments and evaluate analysis protocols for magnetic particle imaging (MPI) studies.
Nicole S. Sarna, Leyda Marrero‐Morales, Ryan DeGroff, Angelie Rivera‐Rodriguez, Sitong Liu, Andreina Chiu‐Lam, Hayden J. Good, Carlos M. Rinaldi‐Ramos   +7 more
doaj   +1 more source

Replacement Strategies for Animal Studies in Inhalation Testing

Sci, 2021
Animal testing is mandatory in drug testing and is the gold standard for toxicity and efficacy evaluations. This situation is expected to change in the future as the 3Rs principle, which stands for the replacement, reduction, and refinement of the use of
Eleonore Fröhlich
doaj   +1 more source

Lessons learned from pre-clinical testing of xenogeneic decellularized esophagi in a rabbit model

iScience, 2022
Summary: Decellularization of esophagi from several species for tissue engineering is well described, but successful implantation in animal models of esophageal replacement has been challenging.
Edward Hannon, Marco Pellegrini, Federico Scottoni, Natalie Durkin, Soichi Shibuya, Roberto Lutman, Toby J. Proctor, J. Ciaran Hutchinson, Owen J. Arthurs, Demetra-Ellie Phylactopoulos, Elizabeth F. Maughan, Colin R. Butler, Simon Eaton, Mark W. Lowdell, Paola Bonfanti, Luca Urbani, Paolo De Coppi   +16 more
doaj   +1 more source

Protecting Canada’s Lab Animals: The Need for Legislation

Animals, 2022
Canada’s current non-legislated oversight system for animal-based science not only fails to adequately incentivize the replacement of sentient animals as best scientific practice in any meaningful way, but also fails to adequately protect those animals ...
Vaughan Black, Andrew Fenton, Elisabeth H. Ormandy   +2 more
doaj   +1 more source