Results 31 to 40 of about 754,514 (306)

Human cardiomyocytes for drug discovery

Vigilância Sanitária em Debate: Sociedade, Ciência & Tecnologia, 2018
Introduction: Cardiac drug discovery are based in old methods that use animals, animal cells or modified cells that do not faithfully represent human cardiac phenotypes.
Diogo Gonçalves Biagi, Jéssica Gonçalves, Estela Cruvinel, Renata Damiani, Flavia Valgode, Fabiana Medeiros, Camila G Moreira, Evelyn Santos, Rodrigo Marcon, Calixto João, Gabriela Venturini, Alexandre Pereira, Éden Ferreira, Renato Mortara, Marcos C Valadares   +14 more
doaj   +7 more sources

Microfluidics : the fur-free way towards personalised medicine in cancer therapy [PDF]

, 2016
Microfluidic technology has great potential for complementing and, in some instances, replacing the use of animal models in the testing of medicines and in developing personalised treatments for cancer patients.
Bower, Ruth, Dawson, Amy, Green, Vicky, Greenman, John   +3 more
core  

Intraoperative Collection of Ascitic Fluid With Intra‐ or Postoperative Reinfusion in Ovarian Cancer: Safety and Feasibility of a Roller Pumping Method

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients with ovarian cancer often present with massive ascites, leading to significant protein loss during surgical procedures. Although cell‐free concentrated ascites reinfusion therapy (CART) is used in palliative settings to mitigate protein loss, its application in intraoperative settings remains unexplored.
Yutaka Yoneoka, Tsukuru Amano, Akimasa Takahashi, Mari Deguchi, Hiroyuki Yamanaka, Yuji Tanaka, Shunichiro Tsuji, Takashi Murakami   +7 more
wiley   +1 more source

Alternative in vitro and in silico models to reduce animal use: a crucial technological advance in dermatological sciences

Expert Reviews in Molecular Medicine
Introduction Alternative models are tools to replace and reduce the number of animals used in biomedical sciences, for either research or tests of industrial products. Several new alternative models have been developed in the most diverse fields.
Carla Zanatelli, Luiza Pretto, Thaís Casagrande Paim, Márcia Rosângela Wink   +3 more
doaj   +1 more source

Non-animal-based options for animal-based foods- towards a systematic terminology

Frontiers in Nutrition, 2023
The market has seen a rapid increase in animal-free products intended to replace animal-based foods due to concerns for human health and environmental sustainability.
Nazanin Abbaspour, Ruben Sanchez-Sabate, Ruben Sanchez-Sabate, Joan Sabaté   +3 more
doaj   +1 more source

In Search of a Sustainable Global Agri-Food System [PDF]

, 2013
The potential to meet global food demand fully exists through global development of the high-technology (HT), high-intensity type of agriculture and food processing system prevailing in developed countries.
Gooday, Andrew, Gooday, Andrew, KITAZATO, HIROSHI, NOMAKI, HIDETAKA, OGURI, KAZUMASA, TSUCHIYA, MASASHI, 北里, 洋, 土屋, 正史, 小栗, 一将, 野牧, 秀隆   +9 more
core   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Potential of a sunflower seed by-product as animal fat replacer in healthier Frankfurters [PDF]

, 2020
Upcycled defatted sunflower seed flour (SUN), a by-product obtained from sunflower oil extraction, was used as an animal fat replacer to develop healthier frankfurters.
Grasso, Simona, Herrero, Ana Maria, Pintado, Tatiana, Pérez-Jiménez, Jara, Ruiz-Capillas, Claudia   +4 more
core   +1 more source

Replacing Animal Use in Education and Training [PDF]

Alternatives to Laboratory Animals, 2018
In the USA, the general public want the use of animals in medical training to cease, but, at least in Australia, some teachers want it to continue, even when effective non-animal alternatives are available.
openaire   +2 more sources

Percutaneous Aortic Valve Replacement in Animals [PDF]

Circulation, 2004
In 2000, we percutaneously implanted a biological valve in the pulmonary artery of animals. A year later, we repeated the procedure in humans. Harvested from the bovine jugular vein, this valve was tested in vitro to assess its function when submitted to a diastolic pressure of 100 mm Hg, as well as its durability.
Younes Boudjemline, Philipp Bonhoeffer
openaire   +1 more source