Results 261 to 270 of about 262,015 (339)

Use of Alternatives to Animal Testing for Environmental Safety Assessment (ESA): Report from the 2023 EPAA Partners’ Forum

José Tarazona, Ana Fernandez-Agudo, Ondřej Adamovský, Marta Baccaro, Natalie Burden, Bruno Campos, Björn Hidding, Karen Jenner, David John, Katia Lacasse, Adam Lillicrap, Delina Y. Lyon, Samuel K. Maynard, Amelie Ott, Véronique Poulsen, M.M.M. Rasenberg, Katrin Schütte, M. Sobanska, James R. Wheeler   +18 more
openalex   +1 more source

BCS1L‐Associated Disease: 5′‐UTR Variant Shifts the Phenotype Towards Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the consequences of a pathogenic missense variant (c.838C>T; p.L280F) and a 5′‐UTR regulatory variant (c.‐122G>T) in BCS1L on disease pathogenesis and to understand how regulatory variants influence disease severity and clinical presentation.
Rotem Orbach, Nunziata Maio, Russell J. Butterfield, A. Reghan Foley, Sarah Silverstein, Yan Li, Katherine Chao, Tanya J. Lehky, Abigail Potticary, Tracey A. Rouault, Sandra Donkervoort, Carsten G. Bönnemann   +11 more
wiley   +1 more source

The Effect of Commercially Available Sugar Alternatives on <i>Bacillus</i> Probiotic Viability During Baking. [PDF]

Int J Food Sci
Payne J, Holt B, Bellmer D, Wahweah D.
europepmc   +1 more source

DeTox: an In-Silico Alternative to Animal Testing for Predicting Developmental Toxicity Potential

Ricardo Scheufen Tieghi, Marielle Rath, José Teófilo Moreira-Filho, James Wellnitz, Holli‐Joi Martin, Kathleen M. Gates, Helena T. Högberg, Nicole Kleinstreuer, Alexander Tropsha, Eugene Muratov   +9 more
openalex   +1 more source

Bottom-up physiologically-based biokinetic modelling as an alternative to animal testing

, 2019
James Chan
openalex   +2 more sources

A Systematic Clinical Framework for Postimplantation Monitoring in Thalamic Neuromodulation: Insights From Twiddler's Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This case described a 25‐year‐old pregnant woman with refractory multifocal epilepsy, diagnosed in 2020 and treated with bilateral thalamic deep brain stimulation (DBS) targeting the centromedian and pulvinar nuclei. Prior to DBS, she experienced daily focal seizures, often progressing to generalized tonic–clonic seizures despite optimal ...
Shalin Shah, Ganne Chaitanya, Jeston Chin, Nicholas Delcimmuto, Jay R. Gavvala   +4 more
wiley   +1 more source

Solutions to the Dilemma of Antibiotics Use in Livestock and Poultry Farming: Regulation Policy and Alternatives. [PDF]

Toxics
Zheng S, Li Y, Chen C, Wang N, Yang F.
europepmc   +1 more source

Alternative Methods Replacing Animal Testing in Research: An Overview

, 2019
Abhishek Singh, Preeti Singh
openalex   +1 more source

The Comparative Effectiveness and Tolerability of Sphingosine‐1‐Phosphate Receptor Modulators in Patients With Multiple Sclerosis: A Network Meta‐Analysis of Randomized Controlled Trials

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Sphingosine‐1‐phosphate receptor modulators (S1PRM) are used to treat relapsing multiple sclerosis (MS). Each drug has a different S1PR‐subtype selectivity. They target the G‐protein coupled S1P receptors and exert significant immunomodulatory effects, such as preventing the formation of new CNS lesions and the reactivation of pre ...
Faizan Shahzad, Taimoon Rasheed, Momina Riaz Siddiqui, Hamza Hamid, Marwah Bintay Khalid, Haroon Shabbir, Besher Shami, Abdullah, Syed Ijlal Ahmed   +8 more
wiley   +1 more source

Practical implementation and impact of the 4R principles in ethnopharmacology: Pursuing a more humane approach to research. [PDF]

Front Pharmacol
Liu J, Zai X, Tian X, Li J, Yan S, Wang T.   +5 more
europepmc   +1 more source