Prediction of membrane transport proteins and their substrate specificities using primary sequence information. [PDF]
PLoS ONE, 2014 Membrane transport proteins (transporters) move hydrophilic substrates across hydrophobic membranes and play vital roles in most cellular functions. Transporters represent a diverse group of proteins that differ in topology, energy coupling mechanism ...
Nitish K Mishra +2 more
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Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain [PDF]
, 2017 There is accumulating evidence that bumetanide, which has been used over decades as a potent loop diuretic, also exerts effects on brain disorders, including autism, neonatal seizures, and epilepsy, which are not related to its effects on the kidney but ...
Erker, Thomas +7 more
core +2 more sources
Effect of a bound anion on the structure and dynamics of halorhodopsin from Natronomonas pharaonis
Structural Dynamics, 2019 Active ion transport across membranes is vital to maintaining the electrochemical gradients of ions in cells and is mediated by transmembrane proteins. Halorhodopsin (HR) functions as a light-driven inward pump for chloride ions. The protein contains all-
Misao Mizuno +3 more
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Bioinformatic characterization of the Anoctamin Superfamily of Ca2+-activated ion channels and lipid scramblases. [PDF]
PLoS ONE, 2018 Our laboratory has developed bioinformatic strategies for identifying distant phylogenetic relationships and characterizing families and superfamilies of transport proteins.
Arturo Medrano-Soto +5 more
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Anion Transport by Proteins: Protein Motifs Involved in Anion Binding
, 2022 Various cellular processes require the participation of specific anions, including Cl-, F-, I-, HCO3- and CO32-. However, their ionic charges impede their permeation across the hydrophobic lipid bilayers of the cells. Cell membranes thus contain specific macromolecular transport proteins, ion channels and transporters, to facilitate and control the ...
openaire +2 more sources
Anion transport by the cochlear motor protein prestin
The Journal of Physiology, 2011 Non‐technical summary Cochlear inner hair cells transform acoustic signals into electric signals. Another type of hair cells, outer hair cells, actively amplifies sensory signals and thus contributes to the exquisite sensitivity of the human auditory system.
Michael, Schänzler, Christoph, Fahlke
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Hepatocanalicular organic-anion transport is regulated by protein kinase C [PDF]
Biochemical Journal, 1991 In order to investigate the regulation of canalicular organic-anion transport, we used a hepatocyte transport assay in which canalicular secretion of a model organic anion, dinitrophenyl-glutathione (GS-DNP), was measured in the presence of stimulators and inhibitors of the Ca2+/protein kinase C (PKC) second-messenger system and of the cyclic AMP (cAMP)
Roelofsen, H. +3 more
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Membranes, 2020 Transmembrane transport of monocarboxylates is conferred by structurally diverse membrane proteins. Here, we describe the pH dependence of lactic acid/lactate facilitation of an aquaporin (AQP9), a monocarboxylate transporter (MCT1, SLC16A1), and a ...
Annika Bader, Eric Beitz
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The Role of Uptake and Efflux Transporters in the Disposition of Glucuronide and Sulfate Conjugates
Frontiers in Pharmacology, 2022 Glucuronidation and sulfation are the most typical phase II metabolic reactions of drugs. The resulting glucuronide and sulfate conjugates are generally considered inactive and safe.
Erkka Järvinen +6 more
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Functional characterization and discovery of modulators of SbMATE, the agronomically important aluminium tolerance transporter from Sorghum bicolor. [PDF]
, 2017 About 50% of the world's arable land is strongly acidic (pH ≤ 5). The low pH solubilizes root-toxic ionic aluminium (Al3+) species from clay minerals, driving the evolution of counteractive adaptations in cultivated crops.
Chang, Geoffrey +6 more
core +3 more sources