Results 181 to 190 of about 9,634,082 (235)

Ankyrin-B and Mtor Complex 1 In The Regulation of Electrical Activities In The Heart

, 2015
The mammalian target of rapamycin complex 1 (mTORC1) activity is paramount in the regulation of electrical activities in the brain and the heart. In the brain, the tumor suppressor gene TSC2 encodes the protein product tuberin that interacts with ...
Wu, Henry C
core  

Effects of Different SNP Calling and Sequence Mapping Choices on the Inference of Genetic Architecture Underlying Migration Tendency

Ecology and Evolution, Volume 16, Issue 6, June 2026.
We re‐analysed RAD‐Seq data from brown trout using a conspecific reference genome and alternative SNP pipelines. Population structure was robust across methods, but using the brown trout reference improved detection of biologically relevant outlier SNPs. ABSTRACT Genome‐wide association studies with identification of biologically relevant genes rely on
Giovanna Mottola, Frank Panitz, Tuomas Leinonen, Alexandre Lemopoulos, Anssi Vainikka   +4 more
wiley   +1 more source

Ankyrin-B Q1283H Variant Linked to Arrhythmias Via Loss of Local Protein Phosphatase 2A Activity Causes Ryanodine Receptor Hyperphosphorylation. [PDF]

Circulation, 2018
Zhu W, Wang C, Hu J, Wan R, Yu J, Xie J, Ma J, Guo L, Ge J, Qiu Y, Chen L, Liu H, Yan X, Liu X, Ye J, He W, Shen Y, Wang C, Mohler PJ, Hong K.   +19 more
europepmc   +1 more source

Cell-autonomous adiposity through increased cell surface GLUT4 due to ankyrin-B deficiency. [PDF]

Proc Natl Acad Sci U S A, 2017
Lorenzo DN, Bennett V.
europepmc   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, Volume 2, Issue 2, June 2026.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Extracellular Vesicles of Giardia duodenalis: Unravelling Their Virulence Factors and Potential to Induce Protection Against Experimental Giardiasis

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
ABSTRACT Extracellular vesicles (EVs) are key mediators of intercellular communication, enabling trans‐kingdom exchange of proteins, nucleic acids, lipids, and metabolites. In Giardia duodenalis, EVs contribute to parasite survival, host–pathogen interactions, and immune modulation.
Corral‐Ruiz Gerardo, Argüello‐García Raúl, Ortiz‐Lozano Dalia, Salazar‐Villatoro Lizbeth, Pech‐Santiago Edar Onam, Espinosa‐Cantellano Martha, Hernández‐Cueto Daniel, Silva‐Olivares D. Angélica, Betanzos Abigail, Ortega‐Pierres M. Guadalupe   +9 more
wiley   +1 more source

Disruption of Ankyrin B and Caveolin-1 Interaction Sites Alters Na⁺,K⁺-ATPase Membrane Diffusion. [PDF]

Biophys J, 2017
Junghans C, Vukojević V, Tavraz NN, Maksimov EG, Zuschratter W, Schmitt FJ, Friedrich T.   +6 more
europepmc   +1 more source

Identification of resistance sources and genomic regions regulating spot blotch resistance in Asian bread wheat (Triticum aestivum L.) via genome‐wide association study

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Spot blotch (SB), caused by Bipolaris sorokiniana, is a major yield‐limiting disease of wheat (Triticum aestivum L.) in the warm, humid agroclimatic zones of South Asia. The development of resistant cultivars through molecular approaches offers a sustainable strategy for managing this disease.
Nikita Aggarwal, Xinyao He, Mukesh Rathore, Farkhandah Jan, Vikas Gupta, Reyazul Rouf Mir, Pawan K. Singh   +6 more
wiley   +1 more source

Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion‐dependent β‐thalassaemia

British Journal of Haematology, Volume 208, Issue 6, Page 1980-1992, June 2026.
Summary Omics technologies have transformed research in haemoglobinopathies, yet the proteome of RBCs remains largely unexplored in transfusion‐dependent thalassaemia (TDT). In this proteomic analysis, Red blood cell (RBC) membranes from 48 adults with TDT were compared with healthy controls.
Konstantina Theocharaki, Sophia Delicou, Aikaterini Ntzoura‐Kani, Nikolaos Simantiris, Marianna Politou, Veroniki Komninaka, Martina Samiotaki, Jerome Zoidakis, Marianna H. Antonelou   +8 more
wiley   +1 more source

Functional Data Strengthen Clinical Validation of PhenoScore Phenotype‐Guided AI for ANKRD11 Missense Variants

Clinical Genetics, Volume 109, Issue 6, Page 1038-1048, June 2026.
PhenoScore, an AI framework integrating facial recognition and clinical phenotype data, accurately identifies pathogenic ANKRD11 missense variants associated with KBG syndrome (AUC 0.95). Validated against functional data, PhenoScore outperforms REVEL and complements AlphaMissense, providing objective phenotypic evidence to reduce variants of uncertain
Evi Andriessen, Elke de Boer, Gholson J. Lyon, Bert B. A. de Vries, Charlotte W. Ockeloen, Alexander J. M. Dingemans   +5 more
wiley   +1 more source