Results 1 to 10 of about 2,806 (200)
Pleiotropic Ankyrins: Scaffolds for Ion Channels and Transporters [PDF]
Channels, 2022 The ankyrin proteins (Ankyrin-R, Ankyrin-B, and Ankyrin-G) are a family of scaffolding, or membrane adaptor proteins necessary for the regulation and targeting of several types of ion channels and membrane transporters throughout the body.
Sharon R. Stevens, Matthew N. Rasband
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The toxins of vertically transmitted Spiroplasma [PDF]
Frontiers in Microbiology, 2023 Vertically transmitted (VT) microbial symbionts play a vital role in the evolution of their insect hosts. A longstanding question in symbiont research is what genes help promote long-term stability of vertically transmitted lifestyles.
Logan D. Moore, Matthew J. Ballinger
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Antiviral activity of recombinant ankyrin targeted to the capsid domain of HIV-1 Gag polyprotein [PDF]
Retrovirology, 2012 Background Ankyrins are cellular mediators of a number of essential protein-protein interactions. Unlike intrabodies, ankyrins are composed of highly structured repeat modules characterized by disulfide bridge-independent folding.
Nangola Sawitree +8 more
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Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment. [PDF]
PLoS Genetics, 2016 In vertebrate neurons, the axon initial segment (AIS) is specialized for action potential initiation. It is organized by a giant 480 Kd variant of ankyrin G (AnkG) that serves as an anchor for ion channels and is required for a plasma membrane diffusion ...
Timothy Jegla +9 more
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The Ankyrin Repeat Domain Controls Presynaptic Localization of Drosophila Ankyrin2 and Is Essential for Synaptic Stability [PDF]
Frontiers in Cell and Developmental Biology, 2019 The structural integrity of synaptic connections critically depends on the interaction between synaptic cell adhesion molecules (CAMs) and the underlying actin and microtubule cytoskeleton.
Tobias Weber +3 more
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Ankyrin-dependent Na+ channel clustering prevents neuromuscular synapse fatigue. [PDF]
Curr Biol, 2021 Skeletal muscle contraction depends on activation of clustered acetylcholine receptors (AchRs) and muscle-specific Na+ channels (Nav1.4). Some Nav1.4 channels are highly enriched at the neuromuscular junction (NMJ) and their clustering is thought to be ...
Zhang C +8 more
europepmc +3 more sources
Ankrd31 in Sperm and Epididymal Integrity
Frontiers in Cell and Developmental Biology, 2021 Ankyrin proteins (ANKRD) are key mediators linking membrane and sub-membranous cytoskeletal proteins. Recent findings have highlighted a new role of ANKRD31 during spermatogenesis, elucidating its involvement in meiotic recombination and male germ cell ...
Francesco Manfrevola +13 more
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Frontiers in Cell and Developmental Biology, 2022 Kisspeptins are involved in the regulation of hypothalamic-pituitary-gonadal axis, Leydig cell functions, and testosterone secretion, acting as endogenous ligands of the KISS1 receptor.
Giulia Ricci +12 more
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eLife, 2021 Neuronal ankyrins cluster and link membrane proteins to the actin and spectrin-based cytoskeleton. Among the three vertebrate ankyrins, little is known about neuronal Ankyrin-R (AnkR). We report AnkR is highly enriched in Pv+ fast-spiking interneurons in
Sharon R Stevens +10 more
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Frontiers in Cell and Developmental Biology, 2021 Mammalian brain circuits are wired by dynamic formation and remodeling during development to produce a balance of excitatory and inhibitory synapses. Synaptic regulation is mediated by a complex network of proteins including immunoglobulin (Ig)- class ...
Bryce W. Duncan +2 more
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