Results 21 to 30 of about 2,806 (200)

Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions

eLife, 2017
Ankyrins together with their spectrin partners are the master organizers of micron-scale membrane domains in diverse tissues. The 24 ankyrin (ANK) repeats of ankyrins bind to numerous membrane proteins, linking them to spectrin-based cytoskeletons at ...
Keyu Chen, Jianchao Li, Chao Wang, Zhiyi Wei, Mingjie Zhang   +4 more
doaj   +1 more source

Polydnaviral ankyrin proteins aid parasitic wasp survival by coordinate and selective inhibition of hematopoietic and immune NF-kappa B signaling in insect hosts. [PDF]

PLoS Pathogens, 2013
Polydnaviruses are mutualists of their parasitoid wasps and express genes in immune cells of their Lepidopteran hosts. Polydnaviral genomes carry multiple copies of viral ankyrins or vankyrins.
Gwenaelle Gueguen, Marta E Kalamarz, Johnny Ramroop, Jeffrey Uribe, Shubha Govind   +4 more
doaj   +1 more source

Distribution of Voltage-Gated Sodium Channels and Scaffolding Proteins on Vestibular Calyx Ending Delineates the Axon Initial Segment. [PDF]

J Comp Neurol
Various sodium channel isoforms and their scaffolding proteins are found in four different microdomains in vestibular calyx‐bearing afferents. These microdomains serve different purposes, analogous to the heminode, axon initial segment, and synaptic domains of other types of sensory afferents.
Lysakowski A, Govindaraju AC, Price SD, Gaboyard-Niay S, Calin-Jageman I, Chidavaenzi RL, Eatock RA, Raphael RM, Goldberg JM.   +8 more
europepmc   +2 more sources

Glial βii spectrin contributes to paranode formation and maintenance [PDF]

, 2018
Action potential conduction along myelinated axons depends on high densities of voltage-gated Na channels at the nodes of Ranvier. Flanking each node, paranodal junctions (paranodes) are formed between axons and Schwann cells in the peripheral nervous ...
Benusa, Savannah D., Chang, Kae Jiun, Dupree, Jeffrey L., Galiano, Mauricio Raul, Griggs, Ryan B., Huang, Claire Yu Mei, Liu, Yanhong, Rasband, Matthew N., Susuki, Keiichiro, Tsai, Chang Ru, Yermakov, Leonid M., Zhang, Chuansheng, Zollinger, Daniel R.   +12 more
core   +1 more source

Ankyrins and Spectrins in Cardiovascular Biology and Disease

Frontiers in Physiology, 2017
Ankyrins are adaptor proteins critical for the expression and targeting of cardiac membrane proteins, signaling molecules, and cytoskeletal elements.
Mona M. El Refaey, Mona M. El Refaey, Peter J. Mohler, Peter J. Mohler, Peter J. Mohler   +4 more
doaj   +1 more source

Mechanisms underlying the role of ankyrin-B in cardiac and neurological health and disease

Frontiers in Cardiovascular Medicine, 2022
The ANK2 gene encodes for ankyrin-B (ANKB), one of 3 members of the ankyrin family of proteins, whose name is derived from the Greek word for anchor. ANKB was originally identified in the brain (B denotes “brain”) but has become most widely known for its
Nicole S. York, Juan C. Sanchez-Arias, Alexa C. H. McAdam, Joel E. Rivera, Laura T. Arbour, Laura T. Arbour, Leigh Anne Swayne, Leigh Anne Swayne   +7 more
doaj   +1 more source

Heterotrimeric Go protein links Wnt-Frizzled signaling with ankyrins to regulate the neuronal microtubule cytoskeleton. [PDF]

, 2014
Drosophila neuromuscular junctions (NMJs) represent a powerful model system with which to study glutamatergic synapse formation and remodeling. Several proteins have been implicated in these processes, including components of canonical Wingless ...
Ataman, Bennett, Biernat, Bouley, Brent, Budnik, Collins, Dubreuil, Egger-Adam, Egger-Adam, Ezan, Formstecher, Franco, Gilman, Guan, Gögel, Heidemann, Hornstein, Hortsch, Hummel, Inestrosa, Inoue, Jan, Jordan, Kamakura, Katanaev, Katanaev, Katanaev, Katanaev, Katanaev, Katanayeva, Koch, Koon, Kopein, Korkut, Koval, Koval, Lin, Lin, Liu, Logan, Luo, Mahr, Mathew, Miech, Mosca, Nichols, Packard, Parkes, Pielage, Purvanov, Roos, Santuccione, Schaefer, Schnorrer, Schroll, Sternweis, Tsai, von Maltzahn, Wagh, Winitz, Wolfgang, Zito   +62 more
core   +1 more source

Giant ankyrin-G regulates cardiac function [PDF]

Journal of Biological Chemistry, 2021
Cardiovascular disease (CVD) remains the most common cause of adult morbidity and mortality in developed nations. As a result, predisposition for CVD is increasingly important to understand. Ankyrins are intracellular proteins required for the maintenance of membrane domains.
Omer Cavus, Jordan Williams, Hassan Musa, Mona El Refaey, Dan Gratz, Rebecca Shaheen, Neill A. Schwieterman, Sara Koenig, Steve Antwi-Boasiako, Lindsay J. Young, Xianyao Xu, Mei Han, Loren E. Wold, Thomas J. Hund, Peter J. Mohler, Elisa A. Bradley   +15 more
openaire   +2 more sources

Heme metabolism genes Downregulated in COPD Cachexia. [PDF]

, 2020
IntroductionCachexia contributes to increased mortality and reduced quality of life in Chronic Obstructive Pulmonary Disease (COPD) and may be associated with underlying gene expression changes.
Agusti, Alvar, Arora, Itika, Bhatt, Surya P, Casaburi, Richard, Castaldi, Peter J, Dransfield, Mark T, Hersh, Craig P, Kumar, Preeti L, Lee, Sool, Lomas, David A, McDonald, Merry-Lynn N, Morrow, Jarrett D, Parker, Margaret M, Rennard, Stephen I, Silverman, Edwin K, Tal-Singer, Ruth, Thannickal, Victor J, Tiwari, Hemant K, Washko, George, Wells, J Michael, Wilson, Ava C, Wouters, Emiel FM   +21 more
core   +3 more sources

Structural basis of diverse membrane target recognitions by ankyrins

eLife, 2014
Ankyrin adaptors together with their spectrin partners coordinate diverse ion channels and cell adhesion molecules within plasma membrane domains and thereby promote physiological activities including fast signaling in the heart and nervous system ...
Chao Wang, Zhiyi Wei, Keyu Chen, Fei Ye, Cong Yu, Vann Bennett, Mingjie Zhang   +6 more
doaj   +1 more source