Results 1 to 10 of about 34,295 (207)

Genotoxic agents promote the nuclear accumulation of annexin A2: role of annexin A2 in mitigating DNA damage. [PDF]

PLoS ONE, 2012
Annexin A2 is an abundant cellular protein that is mainly localized in the cytoplasm and plasma membrane, however a small population has been found in the nucleus, suggesting a nuclear function for the protein.
Patricia A Madureira, Richard Hill, Patrick W K Lee, David M Waisman   +3 more
doaj   +24 more sources

Annexin A2 and Kidney Diseases [PDF]

Frontiers in Cell and Developmental Biology, 2022
Annexin A2 is a Ca2+- and phospholipid-binding protein which is widely expressed in various types of cells and tissues. As a multifunctional molecule, annexin A2 is found to be involved in diverse cell functions and processes, such as cell exocytosis ...
Ling Lin, Kebin Hu
doaj   +4 more sources

Annexin A2 antibodies in post-treatment Lyme disease [PDF]

Therapeutic Advances in Infectious Disease
Background: Anti-annexin A2 (AA2) antibodies have been described in Lyme arthritis and erythema migrans, although they have not been described in post-treatment Lyme disease (PTLD).
John B. Miller, Alison W. Rebman, Marcia Daniela Villegas de Flores, Hong Wang, Erika Darrah, John N. Aucott   +5 more
doaj   +4 more sources

Impact of Annexin A2 on virus life cycles [PDF]

Virus Research
Due to the limited size of viral genomes, hijacking host machinery by the viruses taking place throughout the virus life cycle is inevitable for the survival and proliferation of the virus in the infected hosts.
In-Woo Park, Hope K. Fiadjoe, Pankaj Chaudhary   +2 more
doaj   +4 more sources

Annexin A2: the missing piece in the puzzle of pathogen-induced damage [PDF]

Virulence, 2023
Annexin A2 is a Ca2+ regulated protein belonging to the Annexin family and is found in the cytoplasm and cell membrane. It can exist in a monomeric form or in a heterotetrameric form with the S100A10 dimer.
Chao Li, Jianwei Yu, Daoyong Liao, Xiaoling Su, Xinchao Yi, Xue Yang, Jun He   +6 more
doaj   +2 more sources

Annexin A2 in Virus Infection [PDF]

Frontiers in Microbiology, 2018
Viral life cycles consist of three main phases: (1) attachment and entry, (2) genome replication and expression, and (3) assembly, maturation, and egress.
Julia R. Taylor, Joseph G. Skeate, W. Martin Kast, W. Martin Kast, W. Martin Kast   +4 more
doaj   +3 more sources

Collagen-I influences the post-translational regulation, binding partners and role of Annexin A2 in breast cancer progression [PDF]

Frontiers in Oncology, 2023
IntroductionThe extracellular matrix (ECM) has been heavily implicated in the development and progression of cancer. We have previously shown that Annexin A2 is integral in the migration and invasion of breast cancer cells and in the clinical progression
Amira F. Mahdi, Amira F. Mahdi, Joanne Nolan, Joanne Nolan, Ruth Í. O’Connor, Ruth Í. O’Connor, Aoife J. Lowery, Joanna M. Allardyce, Joanna M. Allardyce, Patrick A. Kiely, Patrick A. Kiely, Kieran McGourty, Kieran McGourty, Kieran McGourty   +13 more
doaj   +2 more sources

Membrane Binding Promotes Annexin A2 Oligomerization [PDF]

Cells, 2020
Annexin A2 (AnxA2) is a cytosolic Ca2+ regulated membrane binding protein that can induce lipid domain formation and plays a role in exocytosis and endocytosis.
Anna Lívia Linard Matos, Sergej Kudruk, Johanna Moratz, Milena Heflik, David Grill, Bart Jan Ravoo, Volker Gerke   +6 more
doaj   +3 more sources

Targeting Annexin A2 to reactivate tumor-associated antigens presentation and relieve immune tolerance in liver cancer [PDF]

Journal for ImmunoTherapy of Cancer
Background Tumor cells manipulate the tumor-associated antigens presentation to escape immune surveillance; however, the molecular mechanism is not exactly clear and the measure to intervene is missing.Methods Annexin A2 was knockout by the CRISPR-Cas9 ...
Min Li, Hui Shen, Feng Xie, Feng Lu, Jianxin Yang, Yuxiao Tang, Qicong Shen, Zelong Gao, Mengpu Wu, Chenghua Wu, Jicong Du, Changquan Ling, Yifeng Chai, Xin Dong, Jianxin Qian, Chenqi Li, Zhenhong Guo, Dongyao Wang   +17 more
doaj   +2 more sources

Annexin A2: The Importance of Being Redox Sensitive [PDF]

International Journal of Molecular Sciences, 2013
Hydrogen peroxide (H2O2) is an important second messenger in cellular signal transduction. H2O2-dependent signalling regulates many cellular processes, such as proliferation, differentiation, migration and apoptosis.
Madureira, Patricia, Waisman, David M.
core   +7 more sources