Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy. [PDF]
Nature Communications, 2015 Autophagy is an important degradation pathway, which is induced after starvation, where it buffers nutrient deprivation by recycling macromolecules in organisms from yeast to man. While the classical pathway mediating this response is via mTOR inhibition,
Ghislat, Ghita +11 more
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Identification of natural compounds targeting Annexin A2 with an anti-cancer effect [PDF]
Protein & Cell, 2018 Annexin A2, a multifunctional tumor associated protein, promotes nuclear factor-kappa B (NF-κB) activation by interacting with NF-κB p50 subunit and facilitating its nuclear translocation. Here we demonstrated that two ginsenosides Rg5 (G-Rg5) and Rk1 (G-
Yu-Shi Wang +4 more
doaj +2 more sources
Stroke, 2010 Hemorrhagic transformation, incomplete reperfusion, neurotoxicity, and the short treatment time window comprise major challenges for thrombolytic therapy. Improving tissue plasminogen activator therapy has become one of the highest priorities in the stroke field.
Xiang Fan +7 more
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Annexin A2 heterotetramer in monocyte invasiveness
, 2004 Generation of plasmin is central to cell movement during wound healing, tumor metastasis, and inflammation, and is accelerated when plasminogen binds to cell surface receptors bearing lysine at their carboxy-terminus. The identity of the plasminogen receptor(s) responsible for regulating plasmin generation at the cell surface is currently unclear.
Darin K. Fogg
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Annexin A2 promotes proliferative vitreoretinopathy in response to a macrophage inflammatory signal in mice [PDF]
Nature CommunicationsProliferative vitreoretinopathy is a vision-threatening response to penetrating ocular injury, for which there is no satisfactory treatment. In this disorder, retinal pigment epithelial cells, abandon their attachment to Bruch’s membrane on the scleral ...
Min Luo +7 more
doaj +2 more sources
Ubiquitinated annexin A2 is enriched in the cytoskeleton fraction [PDF]
FEBS Letters, 2004 Annexin A2 is a multifunctional protein and its cellular functions are regulated by post‐translational modifications and ligand binding. When purified from porcine intestinal mucosa and transformed mouse Krebs II cells, SDS–PAGE revealed high‐molecular‐mass forms in addition to the 36 kDa protomer.
Silje U. Lauvrak +5 more
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Annexin A2: A Double-Edged Sword in Pathogen Infection [PDF]
PathogensAnnexin A2 (ANXA2) is a multifunctional calcium- and phospholipid-binding protein that plays an important role in various cells. During pathogen infections, ANXA2 modulates the nuclear factor kappa-B (NF-κB) and cell apoptosis signaling pathways and ...
Tianyu Wang +5 more
doaj +2 more sources
Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface [PDF]
Frontiers in OncologyBackgroundOur earlier research revealed that the secreted lysyl oxidase-like 4 (LOXL4) that is highly elevated in triple-negative breast cancer (TNBC) acts as a catalyst to lock annexin A2 on the cell membrane surface, which accelerates invasive ...
Tetta Takahashi +24 more
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Annexin A2 in Tumors of the Gastrointestinal Tract, Liver, and Pancreas. [PDF]
Cancers (Basel)Christofidis K +7 more
europepmc +3 more sources
The cooperative folding of annexin A2 relies on a transient nonnative intermediate. [PDF]
Biophys J, 2022 Hollås H +7 more
europepmc +3 more sources