Results 81 to 90 of about 34,339 (250)

Annexin A2 facilitates endocytic trafficking of antisense oligonucleotides [PDF]

Nucleic Acids Research, 2016
Chemically modified antisense oligonucleotides (ASOs) designed to mediate site-specific cleavage of RNA by RNase H1 are used as research tools and as therapeutics. ASOs modified with phosphorothioate (PS) linkages enter cells via endocytotic pathways.
Wang, Shiyu, Sun, Hong, Tanowitz, Michael, Liang, Xue-hai, Crooke, Stanley T.   +4 more
openaire   +2 more sources

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

Lysyl oxidase-like 4 exerts an atypical role in breast cancer progression that is dependent on the enzymatic activity that targets the cell-surface annexin A2

Frontiers in Oncology, 2023
BackgroundLOX family members are reported to play pivotal roles in cancer. Unlike their enzymatic activities in collagen cross-linking, their precise cancer functions are unclear.
Ni Luh Gede Yoni Komalasari, Ni Luh Gede Yoni Komalasari, Nahoko Tomonobu, Rie Kinoshita, Youyi Chen, Yoshihiko Sakaguchi, Yuma Gohara, Fan Jiang, Ken-ich Yamamoto, Hitoshi Murata, I Made Winarsa Ruma, I Wayan Sumardika, Jin Zhou, Akira Yamauchi, Futoshi Kuribayashi, Yusuke Inoue, Shinichi Toyooka, Masakiyo Sakaguchi   +17 more
doaj   +1 more source

Cancer-Associated Thrombosis in Cirrhotic Patients with Hepatocellular Carcinoma. [PDF]

, 2018
It is common knowledge that cancer patients are more prone to develop venous thromboembolic complications (VTE). It is therefore not surprising that patients with hepatocellular carcinoma (HCC) present with a significant risk of VTE, with the portal vein
Burra, P, Campello, E, Russo, Fp., Simioni, P, Spiezia, L, Zanetto, A   +5 more
core   +1 more source

Agents that bind annexin A2 suppress ocular neovascularization [PDF]

Journal of Cellular Physiology, 2010
AbstractTM601 is a synthetic polypeptide with sequence derived from the venom of the scorpion Leiurus quinquestriatus that has anti‐neoplastic activity. It has recently been demonstrated to bind annexin A2 on cultured tumor and vascular endothelial cells and to suppress blood vessel growth on chick chorioallantoic membrane.
Raquel, Lima e Silva, Jikui, Shen, Yuan Yuan, Gong, Christopher P, Seidel, Sean F, Hackett, Kamala, Kesavan, Douglas B, Jacoby, Peter A, Campochiaro   +7 more
openaire   +2 more sources

GALNT10 Affects O‐Glycosylation of IGFBP7 to Promote Tumor Vascular Remodeling and Metastasis of Ovarian Cancer

Advanced Science, EarlyView.
The glycosyltransferase GALNT10 facilitates ovarian cancer metastasis through the induction of tumor cell EMT and tumor vascular dysfunction. GALNT10 enhanced the extracellular secretion of IGFBP7 through O‐GalNAc glycosylation modification at the T188 site, which subsequently interacts with CD93 on endothelial cells, leading to vascular remodeling ...
Yanan Zhang, Ayala Zuha, Zhangxin Wu, Aiping Luo, Bixia Jin, Qinkun Sun, Yuan Li, Qiyu Liu, Hongyan Guo, Chunliang Shang   +9 more
wiley   +1 more source

MicroRNA-425-5p modulates osteoporosis by targeting annexin A2

Immunity & Ageing, 2021
Background Studies have shown that the decrease of osteogenic differentiation of bone marrow mesenchymal stem cells (MSC) is an important mechanism of osteoporosis.
Guanghua Chen, Guizhi Huang, Han Lin, Xinyou Wu, Xiaoyan Tan, Zhoutao Chen   +5 more
doaj   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

RNA-binding is an ancient trait of the Annexin family

Frontiers in Cell and Developmental Biology, 2023
Introduction: The regulation of intracellular functions in mammalian cells involves close coordination of cellular processes. During recent years it has become evident that the sorting, trafficking and distribution of transport vesicles and mRNA granules/
Sudarshan S. Patil, Vipul Panchal, Trude Røstbø, Sofya Romanyuk, Hanne Hollås, Ruth Brenk, Ann Kari Grindheim, Anni Vedeler   +7 more
doaj   +1 more source

Arrangement of Annexin A2 tetramer and its impact on the structure and diffusivity of supported lipid bilayers

, 2010
Annexins are a family of proteins that bind to anionic phospholipid membranes in a Ca2+-dependent manner. Annexin A2 forms heterotetramers (Anx A2t) with the S100A10 (p11) protein dimer.
Barbara Windschiegl, Bert Nickel, Biener, Burger, Casal, Chasserot-Golaz, Claudia Steinem, Cremer, Daniel, Dermine, Dertinger, Dietrich, Esteban-Martín, Faure, Feigenson, Fenz, Filipenko, Fischer, Fritz, Georg Fritz, Gerke, Gilmanshin, Heimburg, Hochrein, Horton, Kirstin Fritz, Klauda, Kucerka, Kucerka, Ladha, Lambert, Lambert, Lewit-Bentley, Liangfang, Lin, Mattai, May, Menke, Miller, Nakata, Nevot, Nickel, Novakova, Parratt, Ratto, Reich, Reich, Richter, Richter, Rosengarth, Ross, Réty, Santos, Schalke, Schulz, Scomparin, Shreve, Trauble, Vacklin, Waisman, Wallace, Watkins   +61 more
core   +1 more source