Results 21 to 30 of about 25,326,638 (176)
Increased complexity of Tmem16a/Anoctamin 1 transcript alternative splicing [PDF]
BMC Molecular Biology, 2011 Abstract Background TMEM16A (Anoctamin 1; ANO1) is an eight transmembrane protein that functions as a calcium-activated chloride channel. TMEM16A in human exhibits alternatively spliced exons (6b, 13 and 15), which confer important roles in the regulation of channel function. Mouse Tmem16a is reported to consist of 25
O'Driscoll, Kate E +2 more
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Transmembrane protein 16A/anoctamin 1 inhibitor T16A-A01 reversed monocrotaline-induced rat pulmonary arterial hypertension [PDF]
Pulmonary Circulation, 2020 Transmembrane protein 16A was involved in the development of the monocrotaline-induced pulmonary arterial hypertension model through ERK1/2 activation, and it was considered as potential target for pulmonary arterial hypertension treatment.
Jianye Xie +9 more
doaj +2 more sources
Anoctamin 1/TMEM16A controls intestinal Cl− secretion induced by carbachol and cholera toxin [PDF]
Experimental and Molecular Medicine, 2019 Colitis: Intestinal membrane protein implicated in defective fluid secretion An ion channel, a membrane protein allowing ion transport, that controls the flow of chloride is needed for proper secretion of protective fluids in the intestine.
Byeongjun Lee +12 more
doaj +2 more sources
Attenuation of Ampullary Anoctamin 1 by the peritoneal fluid in rhesus macaques with spontaneous endometriosis†. [PDF]
Biol ReprodAbstract Altered peristaltic and ciliary dysfunction is a feature of females with endometriosis. To further explore this premise, we examined the ampulla of rhesus macaques (Macaca mulatta) with and without spontaneous endometriosis for the expression of adenylate kinase 7 (AK7), a mitochondrial-dwelling nucleotide converting enzyme with
Luo F, Slayden O.
europepmc +3 more sources
Direct repression of anoctamin 1 (ANO1) gene transcription by Gli proteins. [PDF]
FASEB J, 2019 ABSTRACT The Ca 2+ ‐activated Cl − channel, anoctamin 1 (Ano1, also known as transmembrane protein 16A) contributes to intestinal pacemaking, fluid secretion, cellular excitability, and tissue development. The human
Mazzone A +8 more
europepmc +3 more sources
Frontiers in Bioscience-Landmark, 2022 Background: Autosomal dominant polycystic kidney disease (ADPKD) is a ciliopathy characterized by abnormal tubular epithelial proliferation and fluid secretion. Anoctamin 1 (ANO1) is a calcium-dependent chloride channel.
Tao Xu +7 more
doaj +3 more sources
Differential expression of anoctamin 1 in human epithelial ovarian cancer.
, 2021 Epithelial ovarian cancer (EOC) is the most lethal gynecologic cancer (1). We performed discovery of genes associated with epithelial ovarian cancer and of the high-grade serous ovarian cancer (HGSC) subtype, using published and public microarray data (2, 3) to compare global gene expression profiles of normal ovary or fallopian tube with that of ...
Shahan Mamoor
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Research and optimization of screening strategy for calcium-activated chloride channel modulators guided by electrophysiological characteristics [PDF]
Scientific ReportsCalcium-activated chloride channels (CaCCs) are essential for epithelial secretion, neuronal transmission, and smooth muscle function. Among the Anoctamin family, Anoctamin 1 (ANO1) and Anoctamin 2 (ANO2) are classical CaCCs proteins.
Yanyan Wang +9 more
doaj +2 more sources
Natural Product Research, 2020 Ten triterpenoid glycosides including two undescribed compounds (1 and 2) were isolated from the methanol extract of Allium ascalonicum rhizomes. These compounds were structurally elucidated to be 3β-O-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl-19α-hydroxyolean-12-ene-28-oic acid 28-O-[α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl] ester (1), 3-O-β ...
Nguyễn Thị +12 more
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Anoctamin 1 dysregulation alters bronchial epithelial repair in cystic fibrosis [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2013 Cystic fibrosis (CF) airway epithelium is constantly subjected to injury events due to chronic infection and inflammation. Moreover, abnormalities in CF airway epithelium repair have been described and contribute to the lung function decline seen in CF patients. In the last past years, it has been proposed that anoctamin 1 (ANO1), a Ca(2+)-activated Cl(
Ruffin, Manon +12 more
openaire +5 more sources