Anoctamin-1 Cl Channels in Nociception: Activation by an -Aroylaminothiazole and Capsaicin and Inhibition by T16A[inh]-A01 [PDF]
Molecular Pain, 2015 Background Anoctamin 1 (ANO1 or TMEM16A) Ca 2+ -gated Cl − channels of nociceptor neurons are emerging as important molecular components of peripheral pain transduction. At physiological intracellular Cl − concentrations ([Cl − ] i ) sensory neuronal Cl −
Farah Deba, Bret F. Bessac
doaj +2 more sources
Chloride secretion, anoctamin 1 and Ca(2+) signaling. [PDF]
Channels (Austin), 2014 Kunzelmann K, Schreiber R.
europepmc +4 more sources
Mechanical Stress Modulates Calcium-Activated-Chloride Currents in Differentiating Lens Cells
Frontiers in Physiology, 2022 During accommodation, the lens changes focus by altering its shape following contraction and relaxation of the ciliary muscle. At the cellular level, these changes in shape may be accompanied by fluid flow in and out of individual lens cells.
Lisa Ebihara +3 more
doaj +1 more source
TMEM16A/ANO1: Current Strategies and Novel Drug Approaches for Cystic Fibrosis
Cells, 2021 Cystic fibrosis (CF) is the most common of rare hereditary diseases in Caucasians, and it is estimated to affect 75,000 patients globally. CF is a complex disease due to the multiplicity of mutations found in the CF transmembrane conductance regulator ...
Christie Mitri +3 more
doaj +1 more source
Pain-enhancing mechanism through interaction between TRPV1 and anoctamin 1 in sensory neurons [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Daisuke Uta +2 more
exaly +2 more sources
Calcium-Activated Chloride Channel ANO1/TMEM16A: Regulation of Expression and Signaling
Frontiers in Physiology, 2020 Anoctamin-1 (ANO1), also known as TMEM16A, is the most studied member of anoctamin family of calcium-activated chloride channels with diverse cellular functions.
Nickolai O. Dulin
doaj +1 more source
Anoctamin-5-Myopathie : Klinik, Histologie und Proteom einer Hallenser Kohorte [PDF]
, 2023 Die Anoctamin-5-Myopathie ist eine der häufigsten Ursachen für hereditäre Myopathien in Nordeuropa. Klinisch und histologisch zeigt die Erkrankung ein äußerst heterogenes Bild. Ursächlich sind rezessive Mutationen im Anoctamin-5-Gen.
Richert, Caroline
core +1 more source
Bioinformatic characterization of the Anoctamin Superfamily of Ca2+-activated ion channels and lipid scramblases [PDF]
, 2018 Our laboratory has developed bioinformatic strategies for identifying distant phylogenetic relationships and characterizing families and superfamilies of transport proteins.
Kevin J. Hendargo (5007257) +20 more
core +4 more sources
Paneth Cell Secretion in vivo Requires Expression of Tmem16a and Tmem16f
Gastro Hep Advances, 2022 Background and Aims: Paneth cells play a central role in intestinal innate immune response. These cells are localized at the base of small intestinal crypts of Lieberkuhn.
Rainer Schreiber +2 more
doaj +1 more source
Calcium-activated chloride channels anoctamin 1 and 2 promote murine uterine smooth muscle contractility [PDF]
American Journal of Obstetrics and Gynecology, 2014 Joy Vink +2 more
exaly +2 more sources