Results 91 to 100 of about 25,326,638 (176)

Smooth muscle cell polycystin 1 (PKD1) is dispensable for physiological regulation of arterial contractility

open access: yesThe Journal of Physiology, Volume 604, Issue 15, Page 6348-6368, 1 August 2026.
Abstract figure legend Physiological functions of PKD1, a large transmembrane polycystin protein, are unclear. Previous results obtained using germline non‐specific knockout mice suggested that PKD1 regulates arterial smooth muscle cell contractility.
Angélica K. Bernardelli   +7 more
wiley   +1 more source

Relationship Between Central Sensitization and Genetic Polymorphisms—A Case–Control Study in Fibromyalgia

open access: yesEuropean Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway.
Nicolas Macian   +8 more
wiley   +1 more source

Effects of the Calcium-Activated Chloride Channel Inhibitors T16Ainh-A01 and CaCCinh-A01 on Cardiac Fibroblast Function

open access: yesCellular Physiology and Biochemistry, 2018
Background/Aims: Calcium-activated chloride channels (CaCCs) regulate numerous physiological processes including cell proliferation, migration, and extracellular matrix secretion. T16Ainh-A01 and CaCCinh-A01 are selective inhibitors of CaCCs.
Xiang-qin Tian   +5 more
doaj   +1 more source

Salivary Extracellular Vesicles: Paradigm Shift in Liquid Biopsy Diagnostics

open access: yesJournal of Extracellular Biology, Volume 5, Issue 7, July 2026.
ABSTRACT Extracellular vesicles (EVs), lipid bilayer nanoparticles released by virtually all cells, serve as essential messengers for intercellular communication. Due to their involvement in several pathophysiological processes, EVs have recently gained considerable attention as potentially diagnostic and prognostic biomarkers for various illnesses ...
Kwanele Xulu   +3 more
wiley   +1 more source

TMEM16A-encoded anoctamin 1 inhibition contributes to chrysin-induced coronary relaxation

open access: yesBiomedicine & Pharmacotherapy, 2020
Chrysin, a natural flavonoid available in honey, propolis and medicinal plants, has been shown to be vasorelaxant in some vascular beds. Proper intake of an alimental vasodilator as a food additive may be a promising strategy for prevention and treatment of coronary spasmodic disorders.TMEM16A-encoded anoctamin 1 (ANO1), a Ca2+ activated Cl- channel ...
Guijin, Ma   +7 more
openaire   +2 more sources

Anoctamin‐1 channel localization in excitable domains of the heart (893.23)

open access: yesThe FASEB Journal, 2014
Calcium‐activated chloride (Cl Ca ) currents are widely distributed in cardiac tissues and have been implicated to play a role in cardiac physiology and pathophysiology. Anoctamin‐1 (Ano1) is a membrane protein that functions as a Cl Ca channel and has ...
Fiona Britton   +2 more
openaire   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

open access: yesPhytotherapy Research, Volume 40, Issue 7, Page 4676-4709, July 2026.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández   +5 more
wiley   +1 more source

Potential Virulence Factors in Pyrenophora teres Through Label‐Free Cellular Proteomics Analysis

open access: yesPlant Pathology, Volume 75, Issue 4, July‐August 2026.
This study presents the first label‐free proteomic profile of Pyrenophora teres, identifying potential virulence factors unique to virulent isolates. These proteins were mapped to the P. teres f. teres reference genome and previously identified virulence QTL, providing a valuable resource for future research. ABSTRACT Pyrenophora teres f.
Buddhika A. Dahanayaka   +3 more
wiley   +1 more source

Characterization of TMEM16F-Specific Affibodies and Their Cellular Effects

open access: yesMembranes
The TMEM16 (Anoctamin) family comprises a group of transmembrane proteins involved in diverse physiological processes, including ion transport and phospholipid scrambling.
Eunyoung Kim   +3 more
doaj   +1 more source

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