Results 41 to 50 of about 4,586,589 (282)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Navigating the introduction of anti-amyloid therapy in Europe: a position statement by individual members of the EADC. [PDF]

Alzheimers Res Ther
Anti-amyloid antibodies for the treatment of Alzheimer´s disease (AD) are currently being evaluated for approval and reimbursement in Europe. An approval brings opportunities, but also challenges to health care systems across Europe. The objective of this position paper is to provide guidance from experts in the field in terms of navigating ...
Frederiksen KS, Boada M, Dubois B, Engelborghs S, Frisoni GB, Georges J, Hort J, Jönsson L, Kramberger MG, Ousset PJ, Scarmeas N, Schmidt R, Schott JM, Spiro L, Waldemar G, Winblad B, Jessen F, Frölich L.   +17 more
europepmc   +8 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Clinical and MRI features associated with amyloid positivity in secondary screening for anti–amyloid‐β therapy

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION In Japan, confirmatory biomarker testing for Alzheimer's disease (AD) is insurance‐covered only when evaluating eligibility for anti–amyloid‐β therapies.
Kazuki Yamada, Masanori Kurihara, Yusuke Akitomi, Kenichiro Sato, Ryosuke Shimasaki, Keiko Hatano, Taro Bannai, Fumio Suzuki, Ko Furuta, Aya Midori Tokumaru, Kenji Ishii, Ryoko Ihara, Atsushi Iwata   +12 more
doaj   +1 more source

Evaluation of Amyloid Polypeptide Aggregation Inhibition and Disaggregation Activity of A-Type Procyanidins

Pharmaceuticals, 2021
The number of people worldwide suffering from Alzheimer’s disease (AD) and type 2 diabetes (T2D) is on the rise. Amyloid polypeptides are thought to be associated with the onset of both diseases.
Taisei Tanaka, Vipul V. Betkekar, Ken Ohmori, Keisuke Suzuki, Hideyuki Shigemori   +4 more
doaj   +1 more source

Mitochondrial β-amyloid in Alzheimer's disease [PDF]

, 2011
This research is supported by Alzheimer's Research UK, the Wellcome Trust and the Biotechnology and Biological Sciences Research Council.It is well established that the intracellular accumulation of beta-amyloid is associated with Alzheimer’s disease and
Ainge, JA, James A. Ainge, Muirhead, Kirsty Elizabeth Adair, Gunn-Moore, FJ, Muirhead, KE, Laura Aitken, Aitken, Laura, Zoe E. Allen, Allen, Zoe Eleanor, Gunn-Moore, Frank J, Conway, Stuart, Frank J. Gunn-Moore, Allen, ZE, Borger, E, Aitken, L, Borger, Eva, Ainge, James Alexander, Kirsty E.A. Muirhead, Eva Borger, Stuart J. Conway, Borger, Eva; id_orcid, Ainge, James Alexander; id_orcid, Aitken, Laura; id_orcid, Gunn-Moore, Frank J; id_orcid   +23 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer’s Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids

Molecules, 2023
Neurodegeneration of the brain after ischemia is a major cause of severe, long-term disability, dementia, and mortality, which is a global problem. These phenomena are attributed to excitotoxicity, changes in the blood–brain barrier, neuroinflammation ...
Ryszard Pluta, Barbara Miziak, Stanisław J. Czuczwar   +2 more
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Age-Dependent Neuroplasticity Mechanisms in Alzheimer Tg2576 Mice Following Modulation of Brain Amyloid-β Levels [PDF]

, 2013
The objective of this study was to investigate the effects of modulating brain amyloid-b (Ab) levels at different stages of amyloid pathology on synaptic function, inflammatory cell changes and hippocampal neurogenesis, i.e.
Nordberg, A,, Carina M Thomé, Greig, NH, Greig, Nigel H, Thomé, Carina M, Anna M Lilja, Marutle, Amelia, Daniel Gonzalez, Gonzalez, D, Marutle, A,, Lilja, AM, Amelia Marutle, Röjdner, Jennie, Gonzalez, Daniel, Rojdner, J, Elisa Storelli, Storelli, E, Jennie Röjdner, Unger-Lithner, C, Nordberg, Agneta, Tamanna Mustafiz, Mustafiz, T,, Christina Unger-Lithner, Nigel H Greig, Thome, CM, Mustafiz, Tamanna, Lilja, Anna M, Unger-Lithner, Christina, Storelli, Elisa, Agneta Nordberg, Röjdner Jennie, Mustafiz Tamanna, Marutle Amelia, Thomé Carina M., Gonzalez Daniel, Nordberg Agneta, Lilja Anna M., Greig Nigel H., Storelli Elisa, Unger-Lithner Christina   +39 more
core   +2 more sources