Results 51 to 60 of about 4,586,589 (282)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Patients’ choices and eligibility for anti‐amyloid therapy in Japan's universal insurance

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION We examined factors influencing eligibility and treatment initiation for anti‐amyloid therapy in a real‐world setting under Japan's universal insurance.
Ryoko Ihara, Masanori Kurihara, Keiko Hatano, Taro Bannai, Ryosuke Shimasaki, Akira Hatakeyama, Ko Furuta, Fumio Suzuki, Aya M. Tokumaru, Kenji Ishii, Atsushi Iwata   +10 more
doaj   +1 more source

Baseline MRI markers and clinical outcomes during anti-amyloid β therapy: A real-world study in a Japanese dementia center

The Journal of Prevention of Alzheimer's Disease
: IMPORTANCE: Predictors of decline and of amyloid-related imaging abnormalities (ARIA) during anti-amyloid β therapy in routine care are undefined. OBJECTIVE: To identify baseline predictors of cognitive, functional, and safety outcomes. DESIGN, SETTING,
Yuki Kujuro, Marina Saito, Manami Maruko, Kazuko Kamiyama, Aya Nakano, Emi Qian, Teppei Okamura, Daisuke Ito, Toshimi Kageyama, Ichiro Sugiyama, Eriko Ishihara, Tatsuro Kuwahara, Kazunori Moritani, Hitoshi Katai, Hidenori Hattori   +14 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Comparative Safety Profiles of Anti-Amyloid Therapies in Early Alzheimer’s Disease (AD): A Detailed Systematic Review and Meta-Regression Analysis of Amyloid Related Imaging Abnormalities (ARIA) – Incidence and Infusion Reactions for Lecanemab, Donanemab, and Aducanumab

BJPsych Open
Aims: Alzheimer’s disease continues to be a huge health concern around the globe. Although similar recent developments in anti-amyloid therapy are promising, there is concern about some side effects like ARIA.
Sathyan Soundara Rajan, Sneh Babhulkar, Gaurav Uppal, Sharmi Bhattacharyya, Asha Devi Dhandapani   +4 more
doaj   +1 more source

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons, Nuria Guillen, Jordi Sarto, Neus Falgàs, Sergi Borrego‐Écija, Diana Esteller‐Gauxax, Magda Castellví, Adrià Tort‐Merino, Agnès Pérez‐Millan, Anna Antonell, Josep M. Augè Fradera, Gerard Piñol, Iolanda Riba, Anna Carnes‐Vendrell, Marta Cullell, Maria Teresa Osuna, Lorena Bajo, Teresa Romero, Eva Bonjoch, Joan Bello, Susana Fernández, Marta Balagué, Isabel Gómez‐Ruiz, Anuncia Boltes, Claustre Pont, Raquel Cuevas, Sara Carrillo, Laura Iglesias, Teresa Maria Casadevall Codina, Lorena Grau Guinea, Fernando Jose Espada, Raquel Sánchez‐Valle, Mircea Balasa, Albert Lladó   +33 more
wiley   +1 more source

A novel missense variant in a Japanese woman with hereditary Alzheimer's disease

Journal of Alzheimer's Disease Reports
Hereditary Alzheimer's disease (hAD) and PSEN2 variants are rare, and the benefit of anti-amyloid β-directed monoclonal antibody (mAb) therapy is unknown. We encountered a 51-year-old Japanese woman with PSEN2 -associated hAD.
Kazuki Kasuga, Chinami Yuzawa, Katsuya Nakamura, Yusaku Shimizu, Norikazu Hara, Takeshi Ikeuchi, Yoshiki Sekijima   +6 more
doaj   +1 more source

Anti-amyloid Monoclonal Antibodies for Alzheimer’s Disease: A New Hope? (Review)

Безопасность и риск фармакотерапии
INTRODUCTION. Alzheimer’s disease (AD), which becomes more prevalent with increasing life expectancy, is a leading cause of severe cognitive disorders and dementia. In 2021–2024, the Food and Drug Administration (FDA) approved the first disease-modifying
I. A. Mazerkina
doaj   +1 more source

Amyloids: The History of Toxicity and Functionality

Biology, 2021
Proteins can perform their specific function due to their molecular structure. Partial or complete unfolding of the polypeptide chain may lead to the misfolding and aggregation of proteins in turn, resulting in the formation of different structures such ...
Elmira I. Yakupova, Liya G. Bobyleva, Sergey A. Shumeyko, Ivan M. Vikhlyantsev, Alexander G. Bobylev   +4 more
doaj   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source