Results 91 to 100 of about 131,343 (218)

Memory improvement in the AβPP/PS1 mouse model of familial Alzheimer's disease induced by carbamylated-erythropoietin is accompanied by modulation of synaptic genes [PDF]

, 2015
Neuroprotection of erythropoietin (EPO) following long-term administration is hampered by the associated undesirable effects on hematopoiesis and body weight.
Armand-Ugón, Mercedes, Aso Pérez, Ester, Ferrer, Isidro (Ferrer Abizanda), Moreno Castro, Jesús, Riera i Codina, Miquel, Sànchez, Àlex (Sànchez Pla), Vegas Lozano, Esteban   +6 more
core   +1 more source

Role of Neutrophils in Homeostasis and Diseases

MedComm, Volume 6, Issue 10, October 2025.
Neutrophils are involved in the progression of various diseases through multiple mechanisms, including inflammatory responses, endothelial damage, and NETs release. (A) Cancer development and progression; (B) sepsis; (C) COVID‐19; (D) autoimmune diseases; (E) neurodegenerative diseases; (F) T2DM (e.g., diabetic foot ulcers (DFUs)); (G) nonalcoholic ...
Xingyu Chang, Yulin Liu, Junjun Qiu, Keqin Hua   +3 more
wiley   +1 more source

Neuroprotective effects of EpoL against oxidative stress induced by soluble oligomers of Aβ peptide [PDF]

, 2019
Erythropoietin is a glycoproteic hormone that regulates hematopoiesis by acting on its specific receptor (EpoR). The expression of EpoR in the central nervous system (CNS) suggests a role for this hormone in the brain.
Buendia, I., Castillo, C., Fernández-Mendívil, C., Fuentealba, J., López, M. G., Meza, C., Parra, N. C., Saavedra, P., Toledo, J. R.   +8 more
core   +2 more sources

Recognition of Glycine Versus Nonglycine Citrulline Motifs Dictating the HLA Class II Association of Anticitrullinated Protein Antibodies: Insights From Autoantibody Profiling of 6,900 Scandinavian Patients With Rheumatoid Arthritis

Arthritis &Rheumatology, Volume 77, Issue 9, Page 1179-1193, September 2025.
Objective Rheumatoid arthritis (RA)–associated anticitrullinated protein antibodies (ACPAs) target various antigens by binding short citrulline amino acid motifs, resulting in heterogeneous ACPA profiles among patients. Here we analyzed ACPA patterns by recognized citrulline motifs in relation to the RA risk factors HLA‐DRB1 shared epitope (SE) alleles
Linda Mathsson Alm, Helga Westerlind, Isabel Gehring, Monika Hansson, Nasim Ghasemzadeh, Jessica Rojas‐Restrepo, Saedis Saevarsdottir, Joe Sexton, Siri Lillegraven, Espen Haavardsholm, Bente Glintborg, Hilde Berner Hammer, Tore K. Kvien, Merete Lund Hetland, Leonid Padyukov, Swedish Rheumatology Quality Register Biobank Study Group (SRQb), The Danish Rheumatologic Biobank Study Group, Johan Askling, Caroline Grönwall   +18 more
wiley   +1 more source

Genetic variations in A20 DUB domain provide a genetic link to citrullination and neutrophil extracellular traps in systemic lupus erythematosus [PDF]

, 2019
Objectives: Genetic variations in TNFAIP3 (A20) de-ubiquitinase (DUB) domain increase the risk of systemic lupus erythematosus (SLE) and rheumatoid arthritis.
Alexsson, Andrei,, Arthur, Simon,, Bengtsson, Anders,, Cohen, Philip,, Collins, Barry,, Eloranta, Maija Leena,, Gunnarsson, Iva,, Jackson, Sonya,, Jevnikar, Zala,, Johansson, Patrik,, Jönsen, Andreas,, Kastbom, Alf,, Knebel, Axel,, Leonard, Dag,, Lund University., Lund University., Mattsson, Johan,, Nanda, Sambit,, Odqvist, Lina,, Rantapää-Dahlqvist, Solbritt,, Rhedin, Magdalena,, Riise, Rebecca,, Rönnblom, Lars,, Sandling, Johanna K.,, Sjöwall, Christopher,, Svenungsson, Elisabet,, Syvänen, Ann Christine,, Tandre, Karolina,, Thörn, Kristofer,, Vaarala, Outi,, Yrlid, Linda,, Öberg, Lisa,   +31 more
core   +2 more sources

Annual Banned‐Substance Review 17th Edition—Analytical Approaches in Human Sports Drug Testing 2023/2024

Drug Testing and Analysis, Volume 17, Issue 8, Page 1417-1442, August 2025.
Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario  Thevis, Tiia  Kuuranne, Hans  Geyer   +2 more
wiley   +1 more source

Erythropoietin reduces the expression of myostatin in mdx dystrophic mice [PDF]

, 2014
Erythropoietin (EPO) has been well characterized as a renal glycoprotein hormone regulating red blood cell production by inhibiting apoptosis of erythrocyte progenitors in hematopoietic tissues.
Carvalho, Alzira A. S., Carvalho, Maria Helena, Delgado, Pilar O., Feder, David, Ferreira, Leonardo G., Fonseca, Fernando Luiz Affonso, Lioi, V. P., Nunes, Maria Tereza, Oliveira, Luciano P., Rugollini, M., Santomauro, A., Santos, Rosangela Aparecida dos   +11 more
core   +2 more sources

Two cowpea Rubisco activase isoforms for crop thermotolerance

New Phytologist, Volume 247, Issue 3, Page 1199-1217, August 2025.
Summary A vital crop for sub‐Saharan Africa, cowpea productivity, is threatened by climate change, including increased heatwave intensity, duration and frequency. Rubisco activase (Rca) is a key molecular chaperone that maintains Rubisco activity and, due to its thermal sensitivity, is a key target for improving crop climate resilience.
Armida Gjindali, Rhiannon Page, Catherine J. Ashton, Ingrid Robertson, Mike T. Page, Duncan Bloemers, Peter D. Gould, Dawn Worrall, Douglas J. Orr, Elizabete Carmo‐Silva   +9 more
wiley   +1 more source

Autoimmune Diseases: Molecular Pathogenesis and Therapeutic Targets

MedComm, Volume 6, Issue 7, July 2025.
This review provides a comprehensive overview of common autoimmune diseases, details clinical manifestations and summarizes the pathogenesis, including the breakdown of immune tolerance, initiation of autoimmune responses, and their progressive amplification.
Xiaoshuang Song, Hantian Liang, Fang Nan, Wenjing Chen, Junyao Li, Liu He, Yiping Cun, Zhenhong Li, Wei Zhang, Dunfang Zhang   +9 more
wiley   +1 more source

Anti-Modified Peptide Antibodies (AMPAs) in Rheumatoid Arthritis: Study of the Diagnostic Value of Citrullinated, Homocitrullinated, and Acetylated Fibrin/Filaggrin Chimeric Peptides

Diagnostics
Background/Objectives. The presence of anti-citrullinated peptide/protein antibodies (ACPAs), anti-carbamylated peptide/protein antibodies (anti-CarPs), and anti-acetylated peptide/protein antibodies (AAPAs), collectively termed as anti-modified peptide ...
Isabel Haro, Raul Castellanos-Moreira, Raimon Sanmartí, María José Gómara   +3 more
doaj   +1 more source