Results 41 to 50 of about 131,343 (218)

The value of anti-CarP and anti-PAD4 as markers of rheumatoid arthritis in ACPA/RF negative rheumatoid arthritis patients

Therapeutic Advances in Musculoskeletal Disease, 2021
Background: Anti-citrullinated protein antibodies (ACPAs) and rheumatoid factor (RF) are key factors in the American College of Rheumatology/European League Against Rheumatism rheumatoid arthritis (RA) classification criteria markers.
Bogdan Kolarz, Marek Ciesla, Ann K. Rosenthal, Magdalena Dryglewska, Maria Majdan   +4 more
doaj   +1 more source

Evolution of anti-modified protein antibody responses can be driven by consecutive exposure to different post-translational modifications

Arthritis Research & Therapy, 2021
Background Besides anti-citrullinated protein antibodies (ACPA), rheumatoid arthritis patients (RA) often display autoantibody reactivities against other post-translationally modified (PTM) proteins, more specifically carbamylated and acetylated proteins.
M. Volkov, A. S. B. Kampstra, K. A. van Schie, A. Kawakami, M. Tamai, S. Kawashiri, T. Maeda, T. W. J. Huizinga, R. E. M. Toes, D. van der Woude   +9 more
doaj   +1 more source

Antibodies against advanced glycation end-products and malondialdehyde-acetaldehyde adducts identify a new specific subgroup of hitherto patients with seronegative arthritis with a distinct clinical phenotype and an HLA class II association

RMD Open, 2023
Objective In rheumatoid arthritis (RA) around two-thirds of patients are autoantibody positive for rheumatoid factor, anti-citrullinated protein antibodies and/or anti-carbamylated protein antibodies.
Diane van der Woude, Leendert A Trouw, Tom WJ Huizinga, Annette HM van der Helm-van Mil, René EM Toes, Tineke J van Wesemael, Michelle D van den Beukel, Nicole V Borggreven, Anna Titia W Hoogslag   +8 more
doaj   +1 more source

Prevalence, sensitivity and specificity of antibodies against carbamylated proteins in a monocentric cohort of patients with rheumatoid arthritis and other autoimmune rheumatic diseases [PDF]

, 2016
Antibodies against carbamylated proteins (anti-CarP) have been recently identified in the sera of patients with rheumatoid arthritis (RA). The objective of the study was to evaluate the prevalence, sensitivity and specificity of anti-CarP compared to ...
Alessandri, Cristiano, Barbati, Cristiana, Ceccarelli, Fulvia, Colasanti, Tania, Conti, Fabrizio, DI FRANCO, Manuela, Mancini, Riccardo, Morello, Francesca, Pecani, Arbi, Pendolino, Monica, Priori, Roberta, Riccieri, Valeria, Sabatinelli, Danilo, Spinelli, FRANCESCA ROMANA, Truglia, Simona, Valesini, Guido, Vomero, Marta   +16 more
core   +1 more source

Evidence of Site-Specific Mucosal Autoantibody Secretion in Rheumatoid Arthritis. [PDF]

Arthritis Rheumatol
Objective Anti–citrullinated protein antibodies (ACPA) have been detected in sputum and saliva, indicating that anti–modified protein antibodies (AMPA) can be produced at mucosal sites in patients with rheumatoid arthritis (RA). However, the body's largest mucosal compartment, the gut, has not yet been examined.
Derksen VFAM, Martinsson K, van Mourik AG, Wagenaar CA, Toes REM, Walrabenstein W, Sjöberg D, van Schaardenburg D, Huizinga TWJ, Kastbom A, Svärd A, van der Woude D.   +11 more
europepmc   +2 more sources

Anticarbamylated protein antibodies are associated with long-term disability and increased disease activity in patients with early inflammatory arthritis:Results from the Norfolk Arthritis Register [PDF]

, 2015
Objectives: Anticarbamylated protein (anti-CarP) antibodies are a novel family of autoantibodies recently identified in patients with inflammatory arthritis. The aim of this study was to investigate their association with long-term outcomes of disability
Aletaha, Alexander J MacGregor, Anne Barton, Arend, Brink, Burgers, Burska, De, Deborah PM Symmons, Gan, Hecht, Humphreys, Humphreys, Humphreys, Jennifer H Humphreys, Jung, Kosinski, Leendert A Trouw, Marije K Verheul, Mark Lunt, Montes, Nielen, Pope, Quinn, Rene EM Toes, Shi, Shi, Shi, Shidara, Sokolove, Suzanne MM Verstappen, Symmons, van der Helm-van Mil, van der Linden, Wiles, Wolfe, Yee   +36 more
core   +1 more source

Triple Positivity for Anti–Citrullinated Protein Autoantibodies, Rheumatoid Factor, and Anti–Carbamylated Protein Antibodies Conferring High Specificity for Rheumatoid Arthritis

Arthritis & Rheumatology, 2018
In rheumatoid arthritis (RA), anti–citrullinated protein antibodies (ACPAs) and rheumatoid factor (RF) are commonly used to aid in the diagnosis. Although these autoantibodies are mainly found in RA, their specificity is not optimal.
M. Verheul, S. Böhringer, M. Delft, Jonathan D. Jones, W. Rigby, Ryan W. Gan, V. Holers, J. Edison, K. Deane, K. Janssen, J. Westra, M. Brink, S. Rantapää-Dahlqvist, T. Huizinga, A. H. Helm-van Mil, D. Woude, R. Toes, L. Trouw   +17 more
semanticscholar   +1 more source

The Clinical and Research Implications of Anti-carbamylated Protein Antibodies [PDF]

The Journal of Rheumatology, 2017
Autoantibodies play a central role in the clinical management of rheumatoid arthritis (RA). They can be used for diagnostic as well as prognostic purposes. For many years, autoantibody testing in RA was limited to rheumatoid factor (RF), but in the late 1990s, Schellekens and colleagues confirmed that autoantibodies reactive to citrullinated peptides ...
openaire   +2 more sources

Are rheumatoid factor, anti-citrullinated, and anti-carbamylated protein antibodies linked by post-translational modification of IgG? [PDF]

, 2016
This is the author accepted manuscript. The final version is available from the publisher via the DOI in this record.Accepted manuscript online: 2 August 2016No abstract is available.Support for this project was provided by the Cornwall Arthritis ...
Abedi-Valugerdi, Aho, Brink, Clavarino, Jin, Koppejan, Koro, Ling, Lugli, Rangel-Moreno, Tarcsa, Wang   +11 more
core   +1 more source

Anti-carbamylated protein antibodies as a clinical response predictor in rheumatoid arthritis patients treated with abatacept.

Clinical and Experimental Rheumatology, 2020
OBJECTIVES Carbamylation is an irreversible post-translational modification of proteins. The presence of anti-carbamylated protein antibodies (anti-CarP) has been observed in rheumatoid arthritis (RA).
R. Kumar, S. Piantoni, Michele Boldini, E. Garrafa, C. Bazzani, M. Fredi, Roberta Ottaviani, I. Cavazzana, A. Tincani, F. Franceschini   +9 more
semanticscholar   +1 more source