Ofatumumab: a novel monoclonal anti-CD20 antibody [PDF]
Pharmacogenomics and Personalized Medicine, 2010 Thomas S LinGlaxoSmithKline Oncology R&D, Collegeville, PA, USAAbstract: Ofatumumab, a novel humanized monoclonal anti-CD20 antibody, was recently approved by the FDA for the treatment of fludarabine and alemtuzumab refractory chronic lymphocytic
Thomas S Lin
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Switching to ublituximab from prior anti-CD20 monoclonal antibody therapy: a case report series [PDF]
Frontiers in ImmunologyIntroductionAnti-CD20 monoclonal antibody (mAb) therapies used to treat multiple sclerosis (MS) differ in their molecular structures, epitope recognition, and mechanisms of CD20-positive (CD20+) cell lysis, which may impact clinical efficacy and ...
Regina Berkovich +7 more
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Anti‐CD20 monoclonal antibody therapy in postpartum women with neurological conditions [PDF]
Annals of Clinical and Translational Neurology, 2023 Objective Postpartum, patients with multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) have increased risk for disease activity. Anti‐CD20 IgG1 monoclonal antibodies (mAb) are increasingly used as disease‐modifying therapies (DMTs)
Annika Anderson +22 more
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The Development of Ofatumumab, a Fully Human Anti-CD20 Monoclonal Antibody for Practical Use in Relapsing Multiple Sclerosis Treatment [PDF]
Neurology and Therapy, 2023 The importance of B cells in multiple sclerosis (MS) has been demonstrated through the advent of B-cell-depleting anti-CD20 antibody therapies. Ofatumumab is the first fully human anti-CD20 monoclonal antibody (mAb) developed and tested for subcutaneous (
Stephen L Hauser +2 more
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Enhancement of effector functions of anti-CD20 monoclonal antibody by increased afucosylation in CHO cell line through cell culture medium optimization [PDF]
Journal of Genetic Engineering and Biotechnology, 2022 Background Recombinant therapeutic anti-CD20 monoclonal antibody (mAb) is used for the treatment of non-Hodgkin’s lymphoma, a common B cell lymphoma constituting 80% of all lymphomas. Anti-CD20 mAb contains an Fc-linked biantennary glycan. Although, anti-
Bala Reddy Bheemareddy +3 more
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Ofatumumab, a fully human anti-CD20 monoclonal antibody, in the treatment of severe refractory Anti-N-methyl-D-aspartate receptor encephalitis: Two case reports [PDF]
Annals of Indian Academy of Neurology, 2023 Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is a type of autoimmune encephalitis (AE) characterized by antibodies against NMDA receptor. As the most common AE, anti-NMDAR encephalitis affects 54% ~ 80% of patients with AE.
Hongfei Xue +8 more
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Anti-CD20 monoclonal antibodies: reviewing a revolution [PDF]
Human Vaccines and Immunotherapeutics, 2018 Since the inception of rituximab in the 1990s, anti-CD20 monoclonal antibodies have revolutionised the treatment of B cell hematological malignancies and have become a cornerstone of modern gold-standard practice. Additionally, the potent efficacy of these agents in depleting the B cell compartment has been used in the management of a broad array of ...
Stephen Opat
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Successful treatment of prolonged COVID-19 with Bamlanivimab in a patient with severe B-Cell aplasia due to treatment with an anti-CD20 monoclonal antibody: A case report [PDF]
Respiratory Medicine Case Reports, 2021 A 71-year-old female patient with B-cell depletion due to treatment with an anti-CD20 monoclonal antibody was admitted for worsening COVID-19. Overall, she had persistent viral shedding, worsening respiratory failure, and progressive pneumonia that did ...
Ayham Daher +4 more
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The anti-CD20 monoclonal antibody rituximab to treat acquired haemophilia A. [PDF]
Blood Transfus, 2016 Acquired haemophilia A (AHA) is a rare bleeding disorder caused by the development of specific autoantibodies against naturally occurring factor VIII (FVIII). Although about half of cases are idiopathic, AHA may be associated with several non-neoplastic conditions, autoimmune disorders, as well as haematological malignancies, such as chronic ...
D'arena G +4 more
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Anti-CD20 monoclonal antibodies in Systemic Lupus Erythematosus [PDF]
Biologicals, 2021 Systemic Lupus Erythematosus (SLE) is an autoimmune inflammatory condition with a wide spectrum of disease manifestations and severities, resulting in significant morbidity and mortality. The aetiopathogenesis of SLE is complex. Young women and certain ethnicities are commonly affected, suggesting a significant hormonal and genetic influence.
Shah, K, Cragg, M, Leandro, M, Reddy, V
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