Molecules, 2012 Here we used solid-phase methods to prepare oligonucleotides carrying fibrin/ filaggrin citrullinated peptides. Post-synthetic conjugation protocols were successfully applied for the synthesis of oligonucleotides carrying small peptides.
Ramon Eritja +4 more
doaj +1 more source
Autocitrullination confers monocyte chemotactic properties to peptidylarginine deiminase 4
Scientific Reports, 2023 Peptidylarginine deiminase 4 (PAD4) contributes to the production of citrullinated proteins as autoantigens for anti-citrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA). PAD4 can also self-deiminate via autocitrullination.
Ken Yoshida +6 more
doaj +1 more source
Analysis of gut microbiota in rheumatoid arthritis patients. Disease-related dysbiosis and modifications induced by etanercept [PDF]
, 2018 A certain number of studies were carried out to address the question of how dysbiosis could affect the onset and development of rheumatoid arthritis (RA), but little is known about the reciprocal influence between microbiota composition and ...
D'Amelio, R +11 more
core +1 more source
Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers : implications for autoimmunity in rheumatoid arthritis [PDF]
, 2015 Introduction: Smoking is a well-established risk factor for rheumatoid arthritis (RA), and it has been proposed that smoking-induced citrullination renders autoantigens immunogenic.
Bracke, Ken +8 more
core +2 more sources
Mucosa-Environment Interactions in the Pathogenesis of Rheumatoid Arthritis [PDF]
, 2019 Mucosal surfaces play a central role in the pathogenesis of rheumatoid arthritis (RA). Several risk factors, such as cigarette smoking, environmental pollution, and periodontitis interact with the host at the mucosal level, triggering immune system ...
Conti, Fabrizio +5 more
core +1 more source
Quantification of IFNγ- and IL17-producing cells after stimulation with citrullinated proteins in healthy subjects and RA patients [PDF]
, 2013 Antibodies against citrullinated proteins are highly specific for rheumatoid arthritis (RA) and are currently used as a diagnostic marker. In this study, we wanted to quantify the numbers of T cells that react to a wide range of citrullinated proteins in
De Ceuleneer, Marlies +5 more
core +1 more source
Arthritis Research & Therapy, 2021 Background Besides anti-citrullinated protein antibodies (ACPA), rheumatoid arthritis patients (RA) often display autoantibody reactivities against other post-translationally modified (PTM) proteins, more specifically carbamylated and acetylated proteins.
M. Volkov +9 more
doaj +1 more source
Association between antibodies to carbamylated proteins and subclinical atherosclerosis in rheumatoid arthritis patients [PDF]
, 2017 BACKGROUND: Rheumatoid arthritis (RA) patients carry a high risk of cardiovascular morbidity and mortality. The excess of cardiovascular disease cannot be entirely explained by traditional risk factors and the immune system contributes to the development
Alessandri, Cristiano +8 more
core +1 more source
Anti-Carbamylated Protein Antibodies as a Reproducible Independent Type of Rheumatoid Arthritis Autoantibodies. [PDF]
PLoS ONE, 2016 A large fraction of the patients with rheumatoid arthritis (RA) develop specific autoantibodies, which until recently were only of two types, rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA).
Ariana Montes +5 more
doaj +1 more source
Frontiers in Immunology, 2023 Citrullinated neoepitopes have emerged as key triggers of autoantibodies anti-citrullinated protein antibodies (ACPA) synthesis in rheumatoid arthritis (RA) patients.
Minjie Xu +9 more
doaj +1 more source