Results 151 to 160 of about 197,173 (246)
Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.Figure 1 visually summarizes the core biological functions and therapeutic potential of the HGF/c‐Met signaling axis. Abstract Hepatocyte growth factor (HGF) is a multifunctional cytokine that activates the tyrosine kinase activity of its specific receptor, c‐Met (mesenchymal–epithelial transition factor).
Hongqin Sun +7 more
wiley +1 more source
Prevalence of ANA and Anti-GBM Antibodies among Patients with Renal Failure in Tikrit City
Background: End-stage renal disease (ESRD) people need regular hemodialysis because they have chronic renal disease, which is a major health issue. Aim: This study aimed to evaluate the prevalence and characteristics of ANA and Anti-GBM antibodies,
Ahmed, Saba Talal, Salih, Nadia Ibrahim
core +1 more source
Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong +3 more
wiley +1 more source
Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.Tumour‐intrinsic DRAM1, induced by DNA damage and IFN‐γ, activates an autophagy/JAK‐STAT axis that recruits Tregs, causing CD8+ T cell exhaustion and establishing a self‐sustaining, immunotherapy‐resistant “cold” tumour microenvironment. Abstract Background DNA damage‐regulated autophagy modulator 1 (DRAM1) is a lysosomal protein involved in autophagy ...
Jinchun Wu +7 more
wiley +1 more source
HemaSphere, Volume 10, Issue 6, June 2026.Abstract Biological mechanisms underlying clinical heterogeneity in central nervous system lymphoma (CNSL) are largely unknown. While previous studies suggest the chemokine CLL19 as a crucial factor for the formation of CNSL in murine models, its role in human disease remains elusive.
Julia C. Kuehn +28 more
wiley +1 more source
Xiaoyan Lu,* Hangfei Wu,* Yuhao Tan, Xiaowei Mao Department of Neurology, Changhai Hospital, Naval Medical University (Second Military Medical University), Shanghai, People’s Republic of China*These authors contributed equally to this ...
Lu X, Tan Y, Mao X, Wu H
core
RTA‐408 Enhances Radiosensitivity and Inhibited Tumor Progression via JNK Pathway in Glioblastoma
The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 6, June 2026.ABSTRACT Glioblastoma (GBM) is an aggressive brain tumor with poor prognosis owing to its high invasiveness and resistance to therapy. RTA‐408, a synthetic triterpenoid and nuclear factor erythroid 2‐related factor 2 activator, exhibits anti‐inflammatory and anti‐cancer properties; however, its effects on GBM remain unclear. This study investigated the
Hung‐Pei Tsai +6 more
wiley +1 more source
MedComm, Volume 7, Issue 6, June 2026.We identified SRF as the key TF significantly associated with the malignant phenotype and poor prognosis of GBM. SRF forms a transcriptional complex with P54nrb via phase separation to upregulate the expression of OLFML3. OLFML3 activates ECs and promotes angiogenesis by degrading ECM, releasing proangiogenic factors, enhancing cell–cell adhesion, and ...
Zetao Chen +12 more
wiley +1 more source
The Role of N6‐Methyladenosine Modification in Health and Disease
MedComm, Volume 7, Issue 6, June 2026.N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li +6 more
wiley +1 more source
Organoids: From Bench to Bedside Applications
MedComm, Volume 7, Issue 6, June 2026.Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li +6 more
wiley +1 more source