G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy [PDF]
, 2018 G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that form within guanine-rich strands of regulatory genomic regions. G4s have been extensively described in the human genome, especially in telomeres and oncogene promoters; in ...
Richter, Sara N, Ruggiero, Emanuela
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Systematic review of the efficacy and safety of biological therapy for inflammatory conditions in HIV-infected individuals [PDF]
, 2017 Biologic therapies are injectable immunomodulatory agents directed against specific immune cell or chemical targets. They have transformed the lives of HIV-uninfected individuals with severe inflammatory conditions including psoriasis, rheumatoid ...
Fink, DL, Hedley, L, Miller, RF
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Alkaloids from the Sponge Stylissa carteri Present Prospective Scaffolds for the Inhibition of Human Immunodeficiency Virus 1 (HIV-1). [PDF]
, 2016 The sponge Stylissa carteri is known to produce a number of secondary metabolites displaying anti-fouling, anti-inflammatory, and anti-cancer activity. However, the anti-viral potential of metabolites produced by S.
Bader, Theresa Maria +7 more
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Antiviral activity of organic molecules having sulfonamide moiety: An insight of recent research [PDF]
, 2018 Sulfonamide derivatives are well known for their antibacterial activity as manifested by ‘Sulfa Drugs’, for example, sulfamethoxazole etc. In addition, they are associated with a large number of pharmacological activities such as anti-microbial, anti ...
Aslam, S. +4 more
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Anti-HIV therapy: pipeline approaches and future directions [PDF]
, 2011 Human immunodeficiency virus (HIV), with about 30 million deaths and double infections (in developing countries), is an open challenge today for global scientists.
Lavkush Dwivedi, Mansi Shrivastava
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Selectivity of kinases on the activation of tenofovir, an anti-HIV agent
European Journal of Pharmaceutical Sciences, 2013 Nucleoside analogues, used in HIV-therapy, need to be phosphorylated by cellular enzymes in order to become potential substrates for HIV reverse transcriptase. After incorporation into the viral DNA chain, because of lacking of their 3'-hydroxyl groups, they stop the elongation process and lead to the death of the virus. Phosphorylation of the HIV-drug
Varga, Andrea +6 more
openaire +3 more sources
A PERSPECTIVE ON ANTIINFECTIVE AGENTS INTERACTION IN HUMAN IMMUNODEFICIENCY VIRUS PATIENTS WITH MALARIAL INFECTION [PDF]
, 2016 Despite recent research advances in anti-infective agents (achievements), Human immunodeficiency virus (HIV), and malaria infection are currentlyconsidered two main global human health problems. Given the considerable geographical overlap between malaria
Bhopale, Girish M
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Cellulose acetate phthalate, a common pharmaceutical excipient, inactivates HIV-1 and blocks the coreceptor binding site on the virus envelope glycoprotein gp120 [PDF]
, 2001 BACKGROUND: Cellulose acetate phthalate (CAP), a pharmaceutical excipient used for enteric film coating of capsules and tablets, was shown to inhibit infection by the human immunodeficiency virus type 1 (HIV-1) and several herpesviruses. CAP formulations
A Boyum +55 more
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Clinical use of anti-HIV agents
Folia Pharmacologica Japonica, 2007 現在の抗HIV療法は，カクテル療法と言われるように3剤以上の多剤併用で行うことが基本である．国内で承認されている抗HIV薬は，その作用機序から，逆転写酵素阻害薬とプロテアーゼ阻害薬に分類され，逆転写酵素阻害薬は更に，核酸系と非核酸系とに分かれる．一般的には，非核酸系逆転写酵素阻害薬か，または，プロテアーゼ阻害薬をキードラッグとして，それに，2剤の核酸系逆転写酵素阻害薬を組み合わせて投与する．それぞれの薬剤の作用機序，特性，副作用を認識し，相互作用を考慮しつつ，組み合わせて投与することとなる．副作用は，同じ作用機序の薬剤に一般的に見られるものと，薬剤特異的なものがあり，注意が必要である．既に承認されている抗HIV薬の組み合わせのみではコントロール不良な多剤耐性HIVを持つ症例もあり ...
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A dynamic theory of fidelity networks with an application to the spread of HIV/AIDS [PDF]
We study the dynamic stability of fidelity networks, which are networks that form in a mating economy of agents of two types (say men and women), where each agent desires direct links with opposite type agents, while engaging in multiple partnerships is ...
Roberto Serrano, Roland Pongou
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