Recent Progress in Synthesis, POM Analyses and SAR of Coumarin-Hybrids as Potential Anti-HIV Agents—A Mini Review [PDF]
Pharmaceuticals, 2023 The human immunodeficiency virus (HIV) is the primary cause of acquired immune deficiency syndrome (AIDS), one of the deadliest pandemic diseases. Various mechanisms and procedures have been pursued to synthesise several anti-HIV agents, but due to the ...
Mustapha Suleiman +8 more
doaj +4 more sources
Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility. [PDF]
Bioorg Med Chem Lett, 2013 Non-nucleoside inhibitors of HIV-1 reverse transcriptase are reported that have ca. 100-fold greater solubility than the structurally related drugs etravirine and rilpivirine, while retaining high anti-viral activity.
Bollini M +4 more
europepmc +5 more sources
G-Quadruplex Forming Oligonucleotides as Anti-HIV Agents [PDF]
Molecules, 2015 Though a variety of different non-canonical nucleic acids conformations have been recognized, G-quadruplex structures are probably the structural motifs most commonly found within known oligonucleotide-based aptamers.
Domenica Musumeci +2 more
doaj +7 more sources
Computer-aided discovery of anti-HIV agents. [PDF]
Bioorg Med Chem, 2016 A review is provided on efforts in our laboratory over the last decade to discover anti-HIV agents. The work has focused on computer-aided design and synthesis of non-nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs) with collaborative efforts on biological assaying and protein crystallography.
Jorgensen WL.
europepmc +5 more sources
Potential Anti-HIV Agents from Marine Resources: An Overview [PDF]
Marine Drugs, 2010 Human immunodeficiency virus (HIV) infection causes acquired immune deficiency syndrome (AIDS) and is a global public health issue. Anti-HIV therapy involving chemical drugs has improved the life quality of HIV/AIDS patients.
Thanh-Sang Vo, Se-Kwon Kim
doaj +2 more sources
Clinical use of anti-HIV agents
Folia Pharmacologica Japonica, 2007 現在の抗HIV療法は，カクテル療法と言われるように3剤以上の多剤併用で行うことが基本である．国内で承認されている抗HIV薬は，その作用機序から，逆転写酵素阻害薬とプロテアーゼ阻害薬に分類され，逆転写酵素阻害薬は更に，核酸系と非核酸系とに分かれる．一般的には，非核酸系逆転写酵素阻害薬か，または，プロテアーゼ阻害薬をキードラッグとして，それに，2剤の核酸系逆転写酵素阻害薬を組み合わせて投与する．それぞれの薬剤の作用機序，特性，副作用を認識し，相互作用を考慮しつつ，組み合わせて投与することとなる．副作用は，同じ作用機序の薬剤に一般的に見られるものと，薬剤特異的なものがあり，注意が必要である．既に承認されている抗HIV薬の組み合わせのみではコントロール不良な多剤耐性HIVを持つ症例もあり ...
Hiroyuki Gatanaga
openalex +5 more sources
Mangiferin, an Anti-HIV-1 Agent Targeting Protease and Effective against Resistant Strains [PDF]
Molecules, 2011 The anti-HIV-1 activity of mangiferin was evaluated. Mangiferin can inhibit HIV-1ⅢB induced syncytium formation at non-cytotoxic concentrations, with a 50% effective concentration (EC50) at 16.90 μM and a therapeutic index (TI) above 140. Mangiferin also
Rui-Rui Wang +6 more
doaj +2 more sources
In vivo anti-HIV activity of the heparin-activated serine protease inhibitor antithrombin III encapsulated in lymph-targeting immunoliposomes. [PDF]
PLoS ONE, 2012 Endogenous serine protease inhibitors (serpins) are anti-inflammatory mediators with multiple biologic functions. Several serpins have been reported to modulate HIV pathogenesis, or exhibit potent anti-HIV activity in vitro, but the efficacy of serpins ...
Mohammed Asmal +6 more
doaj +14 more sources
Antihuman Immunodeficiency Virus Type 1 (HIV-1) Activity of Rare Earth Metal Complexes of 4-Hydroxycoumarins in Cell Culture [PDF]
Bioinorganic Chemistry and Applications, 2006 The cerium Ce(III), lanthanum La(III), and neodymium Nd(III) complexes with 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one (warfarin) (W) and 3,3′-benzylidenebis[4-hydroxycoumarin] (1) were synthesized and studied for the first time for ...
Ilia Manolov +6 more
doaj +5 more sources
Natural Products as Anti-HIV Agents and Role in HIV-Associated Neurocognitive Disorders (HAND): A Brief Overview [PDF]
Frontiers in Microbiology, 2016 As the threat of Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) persists to rise, effective drug treatments are required to treat the infected people.
Kesava Rao Venkata Kurapati +4 more
doaj +2 more sources