Results 151 to 160 of about 492,595 (235)
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Rationally Designed Multitarget Anti-HIV Agents
Current Medicinal Chemistry, 2013Multitarget-directed ligands (MTDLs), an emerging and appealing drug discovery strategy, utilizing a single chemical entity to inhibit multitargets, was confirmed to be effective in reducing the likelihood of drug resistance, diminishing problems of dosing complexity, drug-drug interactions and toxicities, as well as improving patient compliance.
Peng Zhan, Xinyong Liu
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A Review on Quinoline Derived Scaffolds as Anti-HIV Agents
Mini-Reviews in Medicinal Chemistry, 2019After restricting the proliferation of CD4+T cells, Human Immunodeficiency Virus (HIV), infection persists at a very fast rate causing Acquired Immunodeficiency Syndrome (AIDS). This demands the vigorous need of suitable anti-HIV agents, as existing medicines do not provide a complete cure and exhibit drawbacks like toxicities, drug resistance, side ...
Sourav Kalra +3 more
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Recent Studies on Natural Products as Anti-HIV Agents
Current Medicinal Chemistry, 2000The discovery of medicinal agents capable of specifically inhibiting human immunodeficiency virus (HIV) is urgently needed due to its globally widespread infection. Most of clinically useful anti-HIV agents are nucleosides but their use is limited due to their severe toxicity and emerging drug resistance.
Mankil Jung +3 more
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Design and Development of Integrase Inhibitors as Anti-HIV Agents
Current Medicinal Chemistry, 2003A review is presented on different categories of compounds that have been studied for the inhibition of the HIV-1 integrase to develop anti-HIV agents. These compounds are: oligonucleotides (double-stranded, triplex, and G-quartet), curcumin analogues, polyhydroxylated aromatic compounds, diketo acids, caffeoyl- and galloyl - based compounds ...
Anantha Naik Nagappa, S.P. Gupta
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Therapeutic potential of indole derivatives as anti-HIV agents: A mini-review.
Current Topics in Medicinal Chemistry, 2021Acquired immunodeficiency syndrome (AIDS), caused by human immunodeficiency virus (HIV), is one of the leading causes of human deaths. The advent of different anti-HIV drugs over different disease progress has made AIDS/HIV from a deadly infection to ...
Qingtai Chen +4 more
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Alkaloids as Potential Anti-HIV Agents
Current HIV Research, 2023Background: Alkaloids are nitrogen-containing compounds that are naturally occurring and have a variety of biological activities, including antimicrobial properties. In this study, the authors used a molecular docking approach to evaluate the anti-HIV potential of 64 alkaloids.
Nidhi, Rani +6 more
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Repurposing Phytochemicals as Anti-HIV Agents [PDF]
Journal of Antivirals & Antiretrovirals, 2016 Phytochemicals play crucial role in inhibiting key enzymes involved in HIV-1 replication. Repurposing of phytochemical based anti-HIV drug discovery through cross screening approaches and modern techniques is essential to provide better leads. Anti-HIV leads translated through phytochemicals could overcome current challenges of HIV therapy. Considering
Smita Kulkarni +2 more
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Rational Design of Colchicine Derivatives as anti-HIV Agents via QSAR and Molecular Docking.
Medicinal chemistry, 2019BACKGROUND Human immunodeficiency virus (HIV) is an infective agent that causes an acquired immunodeficiency syndrome (AIDS). Therefore, the rational design of inhibitors for preventing the progression of the disease is required.
A. Worachartcheewan +5 more
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Combinatorial Synthesis of anti‐HIV Agents
ChemInform, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
Ananantha Naik Nagappa +2 more
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