Results 11 to 20 of about 295,334 (238)
Computer-aided discovery of anti-HIV agents. [PDF]
Bioorg Med Chem, 2016 A review is provided on efforts in our laboratory over the last decade to discover anti-HIV agents. The work has focused on computer-aided design and synthesis of non-nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs) with collaborative efforts on biological assaying and protein crystallography.
Jorgensen WL.
europepmc +5 more sources
G-Quadruplex Forming Oligonucleotides as Anti-HIV Agents. [PDF]
Molecules, 2015 Though a variety of different non-canonical nucleic acids conformations have been recognized, G-quadruplex structures are probably the structural motifs most commonly found within known oligonucleotide-based aptamers. This could be ascribed to several factors, as their large conformational diversity, marked responsiveness of their folding/unfolding ...
Musumeci D, Riccardi C, Montesarchio D.
europepmc +7 more sources
Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility. [PDF]
Bioorg Med Chem Lett, 2013 Non-nucleoside inhibitors of HIV-1 reverse transcriptase are reported that have ca. 100-fold greater solubility than the structurally related drugs etravirine and rilpivirine, while retaining high anti-viral activity.
Bollini M +4 more
europepmc +3 more sources
Natural Products as Anti-HIV Agents and Role in HIV-Associated Neurocognitive Disorders (HAND): A Brief Overview. [PDF]
Front Microbiol, 2015 As the threat of Human Immunodeficiency Virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) persists to rise, effective drug treatments are required to treat the infected people.
Kurapati KR +4 more
europepmc +3 more sources
Cyclotides as natural anti‐HIV agents [PDF]
Peptide Science, 2008 AbstractCyclotides are disulfide rich macrocyclic plant peptides that are defined by their unique topology in which a head‐to‐tail cyclized backbone is knotted by the interlocking arrangement of three disulfide bonds. This cyclic cystine knot motif gives the cyclotides exceptional resistance to thermal, chemical, or enzymatic degradation.
Ireland, David C. +4 more
openaire +4 more sources
Anti-HIV agents inspired by antibodies [PDF]
Nature Chemical Biology, 2020 Emergence of drug resistance limits the efficacy of HIV drugs, which currently requires life-long administration. In vitro high-throughput screening for competition with a broadly neutralizing antibody of HIV identified a small molecule that extends the strategies for targeting HIV.
Shan Su, Shibo Jiang, Shibo Jiang
openaire +2 more sources
In Vivo Anti-HIV Activity of the Heparin-Activated Serine Protease Inhibitor Antithrombin III Encapsulated in Lymph-Targeting Immunoliposomes [PDF]
, 2012 Endogenous serine protease inhibitors (serpins) are anti-inflammatory mediators with multiple biologic functions. Several serpins have been reported to modulate HIV pathogenesis, or exhibit potent anti-HIV activity in vitro, but the efficacy of serpins ...
Angela Carville +7 more
core +12 more sources
New AMD3100 derivatives for CXCR4 chemokine receptor targeted molecular imaging studies: synthesis, anti-HIV-1 evaluation and binding affinities [PDF]
, 2015 CXCR4 is a target of growing interest for the development of new therapeutic drugs and imaging agents as its role in multiple disease states has been demonstrated.
Archibald, Stephen J. +14 more
core +1 more source
Electrochemistry of anti-HIV agents
Electrochemistry Communications, 2000 Square wave voltammetry has been used to study the electrochemical behaviour of anti-HIV drugs in aqueous solutions. The oxidation reaction of Carbovir (1) at a Pt microelectrode occurs at 1.12 V versus SCE and the peak current is proportional to the concentration. An electroanalytical technique for the determination of trace concentrations of Carbovir
Yufei Cheng +3 more
openaire +2 more sources
New findings on the d(TGGGAG) sequence: Surprising anti-HIV-1 activity [PDF]
, 2018 The biological relevance of tetramolecular G-quadruplexes especially as anti-HIV agents has been extensively reported in the literature over the last years. In the light of our recent results regarding the slow G-quadruplex folding kinetics of ODNs based
Di Fabio, Giovanni +5 more
core +1 more source