Molecular identification of Trypanosoma brucei brucei and in vitro anti-trypanosomal activity of different parts of methanolic extract of Senna occidentalis [PDF]
Clinical Phytoscience, 2020 Objective The present study investigated the anti-Trypanosoma brucei brucei activity of methanolic extract of Senna occidentalis roots, leaves, stem bark, and seed in vitro and bioactive components of the most active plant part.
Zainab Aliyu Alhafiz +4 more
doaj +3 more sources
Anti-trypanosomal activity of crude root extract of Leptadenia hastata (Pers) decne in Wistar rats infected with Trypanosoma brucei brucei and associated hematological changes [PDF]
Journal of Advanced Veterinary and Animal Research, 2019 Objective: An in vivo study was carried out to evaluate the possible anti-trypanosomal activity of Leptadenia hastata crude root extract with also its associated hematological changes particularly the packed cell volume (PCV) in experimental Trypanosoma ...
Samson Anjikwi Malgwi +7 more
doaj +3 more sources
In Vivo anti-trypanosomal activity of dichloromethane and methanol crude leaf extracts of Dovyalis abyssinica (Salicaceae) against Trypanosoma congolense. [PDF]
BMC Complement Altern Med, 2015 BackgroundAfrican trypanosomiasis affects both humans and livestock in sub-Saharan countries including Ethiopia. Due to limitations to current chemotherapy, there is an urgent need for the development of new, safe, cheap and effective drugs.
Tadesse B +3 more
europepmc +4 more sources
DNA fingerprinting of five Tabebuia species with reference to their anti-trypanosomal activity [PDF]
Pharmaceutical Sciences Asia, 2022 Tabebuia is the largest genus of the Bignoniaceae family, with great importance due to its beautiful decorative flowering trees, as well as, its remarkable biological activities.
Seham El-Hawary +6 more
doaj +2 more sources
Arid-zone Journal of Basic & Applied Research, 2022 In sub-Saharan Africa, trypanosomosis is a constraint on livestock production. Thus, it is imperative to develop alternative strategies since current chemotherapy is bedevilled by high cost and limited access.
Wasagwa John +4 more
openalex +2 more sources
Fundamental &Clinical Pharmacology, Volume 38, Issue 1, Page 72-83, February 2024., 2023 Human African trypanosomosis (HAT) which is also known as sleeping sickness is caused by Trypanosoma brucei gambiense that is endemic in western and central Africa and T. b. rhodesiense that is endemic in eastern and southern Africa.
Anna Seetsi +5 more
semanticscholar +2 more sources
Anti-trypanosomal activity of pentacyclic triterpenes isolated from Austroplenckia populnea (Celastraceae) Atividade anti-tripanosomicida de triterpenes pentacíclicos isolados de Austroplenckia populnea (Celastraceae) [PDF]
Revista do Instituto de Medicina Tropical de São Paulo, 2002 Four pentacyclic triterpenes isolated from Austroplenckia populnea and four compounds of known anti T. cruzi or anti-malarial activity were tested. Of those triterpenes tested 20alpha-hydroxy-tingenone showed high activity, epikatonic acid was less ...
Lucienir Pains DUARTE +4 more
doaj +2 more sources
Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 Amidinobenzimidazole derivatives connected to 1-aryl-substituted 1,2,3-triazole through phenoxymethylene linkers 7a–7e, 8a–8e, and 9a–9e were designed and synthesised with the aim of evaluating their anti-bacterial and anti-trypanosomal activities and ...
Andrea Bistrović +8 more
doaj +3 more sources
Toxicity study and anti-trypanosomal activities of aqueous and methanol whole plant extracts of Brillantaisia owariensis on Trypanosoma brucei-induced infection in BALB/c mice [PDF]
Clinical Phytoscience, 2021 Background The problem of drug resistance and toxicity in trypanosomiasis is ever-increasing, thereby creating a need to search for efficacious and safer alternatives that are of plant origin.
Nafisa Garba Ayawa +4 more
doaj +2 more sources
RSC PharmaceuticsHerein, TF1 and TF2 were successfully encapsulated into PLGA-, PLA- and PCL-microparticle/-nanoparticle systems. The results demonstrate how polymer chain nature and nanoparticle size affect the leishmanicidal activity of encapsulated ...
Karina González +5 more
openalex +3 more sources