Anti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitors. [PDF]
PLoS Neglected Tropical Diseases, 2017 The cysteine protease cruzipain is considered to be a validated target for therapeutic intervention in the treatment of Chagas disease. Anti-trypanosomal activity against the CL Brener strain of T. cruzi was observed in the 0.1 μM to 1 μM range for three
Antonio C B Burtoloso +10 more
doaj +7 more sources
Novel flavanones with anti-trypanosomal activity isolated from Zambian and Tanzanian propolis samples [PDF]
International Journal for Parasitology: Drugs and Drug Resistance, 2020 A bioassay-guided phytochemical investigation of propolis samples from Tanzania and Zambia that screened for activity against Trypanosoma brucei has led to the isolation of two novel flavanones with promising antitrypanosomal activity. The compounds were
Samya S. Alenezi +7 more
doaj +10 more sources
Anti-Trypanosomal Activity of Nigerian Plants and Their Constituents [PDF]
Molecules, 2015 African trypanosomiasis is a vector-borne parasitic disease causing serious risks to the lives of about 60 million people and 48 million cattle globally.
Ngozi Justina Nwodo +4 more
doaj +8 more sources
Anti-trypanosomal activity of crude root extract of Leptadenia hastata (Pers) decne in Wistar rats infected with Trypanosoma brucei brucei and associated hematological changes [PDF]
Journal of Advanced Veterinary and Animal Research, 2019 Objective: An in vivo study was carried out to evaluate the possible anti-trypanosomal activity of Leptadenia hastata crude root extract with also its associated hematological changes particularly the packed cell volume (PCV) in experimental Trypanosoma ...
Samson Anjikwi Malgwi +7 more
doaj +4 more sources
Biodiversity, Anti-Trypanosomal Activity Screening, and Metabolomic Profiling of Actinomycetes Isolated from Mediterranean Sponges. [PDF]
PLoS ONE, 2015 Marine sponge-associated actinomycetes are considered as promising sources for the discovery of novel biologically active compounds. In the present study, a total of 64 actinomycetes were isolated from 12 different marine sponge species that had been ...
Cheng Cheng +6 more
doaj +19 more sources
Anti-trypanosomal activity and DNA fingerprinting of fifteen Euphorbia species using ISSR and SCoT markers [PDF]
Beni-Suef University Journal of Basic and Applied Sciences, 2021 Background Euphorbia is the largest genus in family Euphorbiaceae with a great biological and genetic diversity. The anti-trypanosomal activity of the crude extract of 15 Euphorbia species against Trypanosoma brucei brucei was carried out.
Seham S. El-Hawary +4 more
doaj +3 more sources
Evaluation of the Anti-Trypanosomal Activity of Vietnamese Essential Oils, with Emphasis on Curcuma longa L. and Its Components [PDF]
Molecules, 2019 Human African trypanosomiasis (HAT), known as sleeping sickness and caused by Trypanosoma brucei, is threatening low-income populations in sub-Saharan African countries with 61 million people at risk of infection.
Thanh Binh Le +5 more
doaj +3 more sources
Synthesis, Structure and In Vitro Anti-Trypanosomal Activity of Non-Toxic Arylpyrrole-Based Chalcone Derivatives [PDF]
Molecules, 2020 With an intention of identifying chalcone derivatives exhibiting anti-protozoal activity, a cohort of relatively unexplored arylpyrrole-based chalcone derivatives were synthesized in moderate to good yields.
Ayanda I. Zulu +7 more
doaj +3 more sources
Isolation of a Novel Flavanonol and an Alkylresorcinol with Highly Potent Anti-Trypanosomal Activity from Libyan propolis [PDF]
Molecules, 2019 Twelve propolis samples from different parts of Libya were investigated for their phytochemical constituents. Ethanol extracts of the samples and some purified compounds were tested against Trypanosoma brucei, Plasmodium falciparum and against two ...
Weam Siheri +13 more
doaj +3 more sources
Molecular identification of Trypanosoma brucei brucei and in vitro anti-trypanosomal activity of different parts of methanolic extract of Senna occidentalis [PDF]
Clinical Phytoscience, 2020 Objective The present study investigated the anti-Trypanosoma brucei brucei activity of methanolic extract of Senna occidentalis roots, leaves, stem bark, and seed in vitro and bioactive components of the most active plant part.
Zainab Aliyu Alhafiz +4 more
doaj +3 more sources