Results 41 to 50 of about 581,138 (251)

In vitro anti-trypanosomal activity of crude extract and fractions of Trichoscypha acuminata stem bark, Spathodea campanulata flowers, and Ficus elastica lianas on Trypanosoma brucei brucei

AIMS Molecular Science
The low therapeutic index of available trypanocidal drugs and the increasing emergence of resistant Trypanosoma parasites indicate the urgent need to develop new strategies for trypanosomiasis control.
Jean Emmanuel Mbosso Teinkela, Philippe Belle Ebanda Kedi , Jean Baptiste Hzounda Fokou, Michelle Isaacs, Lisette Pulchérie Yoyo Ngando, Gaelle Wea Tchepnou, Hassan Oumarou, Xavier Siwe Noundou   +7 more
doaj   +2 more sources

Type I-like metalloproteinase in the venom of the West African saw-scaled carpet viper (Echis ocellatus) has anti-trypanosomal activity against African trypanosomes

Toxicon, 2023
Ilu Ameh, Mathias Ahii Chia, Thaís Regiani Cataldi, Carlos Alberto Labate, Godwin U. Ebiloma, Peter Ofemile Yusuf, Mohammed Nasir Shuaibu, E.O. Balogun   +7 more
openalex   +3 more sources

In vitro anti-trypanosomal activity of 3-(aryl)-6-piperazin1,2,4-triazolo[3,4- a ]phthalazines-loaded ultrathin polymeric particles: effect of polymer type and particle size

RSC Pharmaceutics
Herein, TF1 and TF2 were successfully encapsulated into PLGA-, PLA- and PCL-microparticle/-nanoparticle systems. The results demonstrate how polymer chain nature and nanoparticle size affect the leishmanicidal activity of encapsulated ...
Karina González, Ender Medina, Elena Aguilera, Gema González, Marcos A. Sabino, Angel H. Romero   +5 more
openalex   +3 more sources

Evaluation of the anti-trypanosomal activity of Justicia secunda (Vahl) leaf in Trypanosoma brucei infected rats

Sokoto Journal of Veterinary Sciences
The use of plants in traditional medicine is increasingly gaining ground in modern medicine because phytochemical components of most secondary metabolites can be used to treat a wide range of diseases.
CS Ukwueze, MU Ememe, R Unigwe, CG Nwosu
openalex   +3 more sources

Crosspteryx fibrifuga leaf extract enhances host resistance to Trypanosoma congolense infection in mice by regulating host immune response and disrupting the activity of parasite superoxide dismutase enzyme [PDF]

Frontiers in Microbiology, 2023
African trypanosomiasis, a neglected tropical disease, is caused by diverse species of the protozoan parasite belonging to the genus Trypanosoma. Although anti-trypanosomal medications exist, the increase in drug resistance and persistent antigenic ...
Nnamdi Ikeogu, Folayemi Olayinka-Adefemi, Chidalu Edechi, Chukwunonso Onyilagha, Ping Jia, Aaron Marshall, Julius Ode, Jude Uzonna   +7 more
doaj   +2 more sources

Evaluation of in vivo anti-trypanosomal activity of methanol and aqueous extracted Allium sativum and Lepidium sativum against Trypanosoma evansi and Trypanosoma congolense in Southern Ethiopia

Omo International Journal of Sciences
The present study was conducted in Arba Minch town, from September 2022 to April 2023 with the objective of evaluating the anti-trypanosomal activity of aqueous and methanol extract of Allium sativum bulbs and Lepidium sativum seeds against T. evansi and
Selamu Mekonen, Whitney Israel, Lema Lale   +2 more
openalex   +3 more sources

ANTI‐TRYPANOSOMAL ACTIVITY OF CERTAIN PHENYLDIAZOAMINO‐ AND PHENYLAZOAMINO‐PHENANTHRIDINIUM COMPOUNDS [PDF]

British Journal of Pharmacology and Chemotherapy, 1961
Red phenyldiazoaminophenanthridinium and purple phenylazoaminophenanthridinium compounds, most of which were obtained as isomeric pairs, were tested in mice for curative and prophylactic action against Trypanosoma congolense. Several of the individual compounds showed a high degree of activity, the red isomer of each pair usually being more active ...
K. N. Brown, Achille Massougbodji, A. E. HOLLAND   +2 more
openalex   +4 more sources

In Vivo Anti-Trypanosomal Activity of Basil Extract on Trypanosoma evansi

Advances in Animal and Veterinary Sciences, 2023
E. Razin, H. Sobhy, T. Aboelnaga, A. Darwish, R. Mohammed   +4 more
semanticscholar   +2 more sources

<i>In vitro</i> anti-trypanosomal activity of <i>Bitis arietans</i> crude venom against <i>Trypanosoma brucei brucei</i>

, 2019
African Animal trypanosomosis (AAT) otherwise known as Nagana is a resurgent disease in Africa. It is caused by Trypanosoma brucei brucei , Trypanosoma congolense , Trypanosoma vivax , Trypanosoma evansi a mong others.
Gloria Dada Chechet, G. Peter
openalex   +3 more sources

Eugenia uniflora and Syzygium samarangense extracts exhibit anti-trypanosomal activity: Evidence from in-silico molecular modelling, in vitro, and in vivo studies

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021
Mohamed A. O. Abdelfattah, Mohammed Auwal Ibrahim, Hadiza Abdullahi, Raphael Aminu, Saad Bello Saad, Sonja Krstin, Michaël Wink, Mansour Sobeh   +7 more
openalex   +2 more sources