Results 41 to 50 of about 561,822 (204)

Trypanocidal and leishmanicidal activity of six limonoids [PDF]

, 2020
Six limonoids [kotschyienone A and B (1, 2), 7-deacetylgedunin (3), 7-deacetyl-7-oxogedunin (4), andirobin (5) and methyl angolensate (6)] were investigated for their trypanocidal and leishmanicidal activities using bloodstream forms of Trypanosoma ...
A-E Hay, AC Ivens, Bathelemy Ngameni, D Steverding, D Steverding, D Steverding, DAH Taylor, Dietmar Steverding, Evelyne Ollivier, G. Richard Stephenson, Gabriel N. Folefoc, GM Cragg, H Hirumi, J Mikus, K Merschjohann, Kevin M. Tyler, KM Ahua, Lazare S. Sidjui, LS Sidjui, PM Cheuka, S Nwaka, SE Atawodi, SJ Collins, T Baltz, Thomas E. Storr, Valérie Mahiou-Leddet, W Huber, W Ravangpai, Y-B Cheng, Éden Ramalho Ferreira, ÉR Ferreira   +30 more
core   +2 more sources

Phytochemical Analysis, Cytotoxicity, and Antitrypanosomal, Antioxidant, and Anti-Inflammatory Activities of Clausena anisata Fruit, Azadirachta indica Leaf, and Stem Bark Extracts. [PDF]

J Parasitol Res
Human African trypanosomiasis (HAT) is an infectious disease which kills humans and animals as a result of hematological distortions, oxidative stress, tissue and neuroinflammations. This study reports on the differences in cytotoxicity, antitrypanosomal, antioxidant, and anti‐inflammatory activities of ethanol extracts from Clausena anisata fruit (CFE)
Kumatia EK, Zoiku FK, Baffour PK, Anokye-Kumatia AB, Asase A.   +4 more
europepmc   +2 more sources

Design, Synthesis, and Evaluation of An Anti-trypanosomal [1,2,4]Triazolo[1,5-a]pyrimidine Probe for Photoaffinity Labeling Studies. [PDF]

ChemMedChem
We describe here the design, synthesis and evaluation of an anti‐trypanosomal 1,2,4‐triazolo[1,5‐a]pyrimidine (TPD) probe which facilitated the design and execution of PAL experiments in whole HEK293 cells and T. brucei parasites. These experiments confirmed tubulin as a protein target in both HEK293 cells and T. brucei.
Lucero B, Francisco KR, Varricchio C, Liu LJ, Yao Y, Brancale A, Brunden KR, Caffrey CR, Ballatore C.   +8 more
europepmc   +2 more sources

Chemical characterization of Saudi propolis and its antiparasitic and anticancer properties

Scientific Reports, 2021
Propolis, is a gummy material produced by honey bees from different parts of plants and is enriched with varied biological active compounds like flavonoids, phenolics and phenolic acids with wide applicability in the food, pharmaceutical and cosmetics ...
Samyah Alanazi, Naif Alenzi, Fouza Alenazi, Hajera Tabassum, David Watson   +4 more
doaj   +1 more source

The trypanosomal transferrin receptor of trypanosoma brucei : a review [PDF]

, 2019
Iron is an essential element for life. Its uptake and utility requires a careful balancing with its toxic capacity, with mammals evolving a safe and bio-viable means of its transport and storage. This transport and storage is also utilized as part of the
Kariuki, Christopher K., Magez, Stefan, Stijlemans, Benoit   +2 more
core   +2 more sources

Trypanosoma brucei glycogen synthase kinase-3, a target for anti-trypanosomal drug development: a public-private partnership to identify novel leads. [PDF]

PLoS Neglected Tropical Diseases, 2011
Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (HAT), expresses two proteins with homology to human glycogen synthase kinase 3β (HsGSK-3) designated TbruGSK-3 short and TbruGSK-3 long.
Richard O Oduor, Kayode K Ojo, Gareth P Williams, Francois Bertelli, James Mills, Louis Maes, David C Pryde, Tanya Parkinson, Wesley C Van Voorhis, Tod P Holler   +9 more
doaj   +1 more source

In vitro activity of salinomycin and monensin derivatives against Trypanosoma brucei [PDF]

, 2016
Background: African trypanosomes are the causative agents of sleeping sickness in humans and nagana disease in livestock animals. As the few drugs available for treatment of the diseases have limited efficacy and produce adverse reactions, new and better
A Huczyński, A Huczyński, A Huczyński, A Huczyński, A Huczyński, A Huczyński, A Scherzad, Adam Huczyński, AH Fairlamb, D Steverding, DH Molyneux, Dietmar Steverding, E Matovu, GE Moore, H Hirumi, K Merschjohann, M Antoszczak, M Antoszczak, Michał Antoszczak, S Nwaka, SJ Collins, SV Barrett, T Baltz, V Delespaux, W Huber   +24 more
core   +1 more source

EUCALYPTUS OIL NANOEMULSION: EVALUATION OF IN VITRO ACTIVITY AGAINST TRYPANOSOMA BRUCEI [PDF]

Zagazig Journal of Pharmaceutical Sciences
Background: Natural products and their secondary metabolites are a good source of pharmacologically active constituents and have been widely developed into modern medicines.
Emmanuel Maduabuchi Uronnachi, Patience Sunday Ngbo, Somtochukwu Richard Ewuzie, Chidalu Benedicta Ikeotuonye, Anthony Amaechi Attama   +4 more
doaj   +1 more source

Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1 [PDF]

, 2014
The treatment of Human African Trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important and pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp.
Abedawn I. Khalaf, Addie M., Arcari J. T., Baker N., Barrett M. P., Barrett M. P., Bridges D. J., Brun R., Bursavich M. G., Carter N. S., Cavazzuti A., Colin J. Suckling, Colin L. Gibson, Creek D. J., Dawson A., Dincer S., Federica Giordani, Gangjee A., Gibson C. L., Gourley D. G., Judith K. Huggan, Kaspersen S. J., Keri L. Barrack, Kirsten Stewart, Le Brazidec J.-Y., Matovu E., Michael P. Barrett, Mohamed M. S., Mpamhanga C. P., Pui Ee Wong, Raz B., Sienkiewicz N., Simarro P. P., Spinks D., Tari L. W., Taylor E. C., Tessier P. R., Trzoss M., Tulloch L. B., William N. Hunter, Xie H., Zhu G.   +41 more
core   +4 more sources

Affinity is an important determinant of the anti-trypanosome activity of nanobodies.

PLoS Neglected Tropical Diseases, 2012
BackgroundThe discovery of Nanobodies (Nbs) with a direct toxic activity against African trypanosomes is a recent advancement towards a new strategy against these extracellular parasites.
Guy Caljon, Benoît Stijlemans, Dirk Saerens, Jan Van Den Abbeele, Serge Muyldermans, Stefan Magez, Patrick De Baetselier   +6 more
doaj   +1 more source