Results 51 to 60 of about 581,138 (251)

Bioactivity Profiles of Progressively Ring-Fluorinated Cyclohexyl Motifs in the WKYMVm Peptide as Formylpeptide FPR2 Agonists and in Keto-Piperazines as Antitrypanosome Agents. [PDF]

Chembiochem
All‐cis‐fluorinated cyclohexyl motifs with progressively increasing levels of fluorine are introduced into the WKYMVm peptide and a class of keto‐piperazine derivatives and assayed against the FPR2 receptor or the parasite Trypanosoma brucei, respectively.
He M, Thomson CM, Thompson D, Kuodis V, Smith TK, Dall'Angelo S, O'Hagan D.   +6 more
europepmc   +2 more sources

In vitro Anti-Trypanosomal Activities of Indanone-Based Chalcones [PDF]

Drug Research, 2018
Human African trypanosomiasis is a neglected infectious disease that affects mostly people living in the rural areas of Africa. Current treatment options are limited to just four drugs that have been in use of four to nine decades. The life-threatening toxic side-effects associated with the use of these drugs are disconcerting.
Richard M. Beteck, Lesetja J. Legoabe, Michelle Isaacs, Heinrich C. Hoppe   +3 more
openalex   +5 more sources

Trypanocidal Effects of Polyprenylated Benzophenone Enriched Brazilian Red Propolis Extract and Its Isolated Constituent. [PDF]

Chem Biodivers
In vitro trypanocidal activity of a polyprenylated benzophenone‐enriched Brazilian red propolis extract (SEBz) and its major constituents, guttiferone E/xanthochymol (GUT/XAN) and oblongifolin B (OBL), exhibit in vitro trypanocidal activity against Trypanosoma cruzi, inducing ultrastructural damage with moderate cytotoxicity and no significant ...
Oliveira ND, Pagotti MC, Paula LAL, Paixão MZ, Albino Dos Santos D, de Freitas RF, Ambrósio SR, Veneziani RCS, Bastos JK, Magalhães LG.   +9 more
europepmc   +2 more sources

Digalloyl Glycoside: A Potential Inhibitor of Trypanosomal PFK from Euphorbia abyssinica J.F. Gmel

Plants, 2022
Human African trypanosomiasis is an endemic infectious disease caused by Trypanosoma brucei via the bite of tsetse-fly. Most of the drugs used for the treatment, e.g., Suramin, have shown several problems, including the high level of toxicity ...
Seham S. El-Hawary, Rabab Mohammed, Nadia M. Lithy, Sameh Fekry AbouZid, Mostafa A. Mansour, Suliman A. Almahmoud, Bader Huwaimel, Elham Amin   +7 more
doaj   +1 more source

In Vitro Anti-Trypanosoma cruzi Activity of Halophytes from Southern Portugal Reloaded: A Special Focus on Sea Fennel (Crithmum maritimum L.)

Plants, 2021
Marine halophytes are an outstanding reservoir of natural products and several species have anti-infectious traditional uses. However, reports about their potential use against neglected tropical ailments, such as Chagas disease, are scarce.
Catarina G. Pereira, Carolina Borsoi Moraes, Caio H. Franco, Clarissa Feltrin, Raphaël Grougnet, Euzébio Guimarães Barbosa, Michele Panciera, Carlos Roque D. Correia, Maria João Rodrigues, Luísa Custódio   +9 more
doaj   +1 more source

A Chlorodiazirine Analog of Pentamidine with Anti-Trypanosomal Activity

The Journal of Parasitology, 2000
A chlorodiazirine derivative of pentamidine was synthesized and tested for anti-trypanosomal activity using EATRO stock 164 trypanosomes in cell culture. Anti-trypanosomal activity was measured as a decrease in [3H]hypoxanthine incorporation by the organisms.
Alfred C. Nichols, K. Lemone Yielding, Samuel A. O. Agbe   +2 more
openalex   +3 more sources

New Tetromycin Derivatives with Anti-Trypanosomal and Protease Inhibitory Activities [PDF]

Marine Drugs, 2011
Four new tetromycin derivatives, tetromycins 1–4 and a previously known one, tetromycin B (5) were isolated from Streptomyces axinellae Pol001T cultivated from the Mediterranean sponge Axinella polypoides. Structures were assigned using extensive 1D and 2D NMR spectroscopy as well as HRESIMS analysis.
Pimentel-Elardo, Sheila M., Buback, Verena, Gulder, Tobias A. M., Bugni, Tim S., Reppart, Jason, Bringmann, Gerhard, Ireland, Chris M., Schirmeister, Tanja, Hentschel, Ute   +8 more
openaire   +7 more sources

The anti‐Trypanosoma activities of medicinal plants: A systematic review of the literature

Veterinary Medicine and Science, 2022
Background The existing drug treatments for trypanosomiases are limited and suffer from shortcomings due to their toxicity and the emergence of resistant parasites.
Shahin Nekoei, Faham Khamesipour, Solomon Habtemariam, Wanderley deSouza, Pardis Mohammadi Pour, Seyed Reza Hosseini   +5 more
doaj   +1 more source

Trypanocidal and leishmanicidal activity of six limonoids [PDF]

, 2020
Six limonoids [kotschyienone A and B (1, 2), 7-deacetylgedunin (3), 7-deacetyl-7-oxogedunin (4), andirobin (5) and methyl angolensate (6)] were investigated for their trypanocidal and leishmanicidal activities using bloodstream forms of Trypanosoma ...
A-E Hay, AC Ivens, Bathelemy Ngameni, D Steverding, D Steverding, D Steverding, DAH Taylor, Dietmar Steverding, Evelyne Ollivier, G. Richard Stephenson, Gabriel N. Folefoc, GM Cragg, H Hirumi, J Mikus, K Merschjohann, Kevin M. Tyler, KM Ahua, Lazare S. Sidjui, LS Sidjui, PM Cheuka, S Nwaka, SE Atawodi, SJ Collins, T Baltz, Thomas E. Storr, Valérie Mahiou-Leddet, W Huber, W Ravangpai, Y-B Cheng, Éden Ramalho Ferreira, ÉR Ferreira   +30 more
core   +3 more sources

Anti-trypanosomal Activity of Potential Inhibitors of Trypanosoma brucei Glycolytic Pathway Enzymes Selected by Docking Studies

Rwanda Medical Journal, 2014
Human African trypanosomiasis (HAT), a potentially fatal protozoan infection caused by tsetse-fl mediated transmission of Trypanosoma brucei (T. Brucei), is largely recognized as a neglected disease.
Clarisse Musanabaganwa, Fidele Byiringiro   +1 more
doaj   +1 more source