Results 41 to 50 of about 2,259,235 (294)
Frontiers in Chemistry, 2022 The emergence of antibiotic resistance in Staphylococcus aureus has necessitated the development of innovative anti-infective agents acting on novel targets. Alpha-hemolysin (Hla), a key virulence factor of S.
Shi-Jie Wan +21 more
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Autonomous virulence adaptation improves coevolutionary optimization [PDF]
, 2011 A novel approach for the autonomous virulence adaptation (AVA) of competing populations in a coevolutionary optimization framework is presented.
Ait-Boudaoud, D +5 more
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Enzyme targets for drug design of new anti-virulence therapeutics [PDF]
Current Opinion in Structural Biology, 2018 Society has benefitted greatly from the use of antibiotics. Unfortunately, the misuse of these valuable molecules has resulted in increased levels of antibiotic resistance, a major global and public health issue. This resistance and the reliance on a small number of biological targets for the development of antibiotics emphasizes the need for new ...
Charlene M Kahler +4 more
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Tackling Pseudomonas aeruginosa Virulence by Mulinane-Like Diterpenoids from Azorella atacamensis
Biomolecules, 2020 Pseudomonas aeruginosa is an important multidrug-resistant human pathogen by dint of its high intrinsic, acquired, and adaptive resistance mechanisms, causing great concern for immune-compromised individuals and public health. Additionally, P. aeruginosa
Onyedikachi Cecil Azuama +13 more
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Microbiology Spectrum, 2022 Avian pathogenic Escherichia coli (APEC) associated with colibacillosis results in high morbidity and mortality, and severe economic losses to the poultry industry.
Yosra A. Helmy +8 more
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The coevolution of virulence : tolerance in perspective [PDF]
, 2010 Coevolutionary interactions, such as those between host and parasite, predator and prey, or plant and pollinator, evolve subject to the genes of both interactors.
Colegrave, Nick +17 more
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Within-Host Dynamics of Multi-Species Infections:Facilitation, Competition and Virulence [PDF]
, 2012 Host individuals are often infected with more than one parasite species (parasites defined broadly, to include viruses and bacteria). Yet, research in infection biology is dominated by studies on single-parasite infections.
Eswarappa, Sandeepa M. +8 more
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Anti-virulence and bactericidal activities of Stattic against Shigella sonnei
Applied and Environmental Microbiology, 2023 ABSTRACT Shigella sonnei is an important human pathogen that provokes severe colitis and diarrhea, causing high mortality and morbidity worldwide. Because of increasing drug resistance, it is particularly important to develop new antibacterial agents against S. sonnei . In this study, we report
Mingfang Wang +8 more
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Novel cyclic di-GMP effectors of the YajQ protein family control bacterial virulence [PDF]
, 2014 Bis-(3',5') cyclic di-guanylate (cyclic di-GMP) is a key bacterial second messenger that is implicated in the regulation of many critical processes that include motility, biofilm formation and virulence. Cyclic di-GMP influences diverse functions through
Caly, Delphine L. +32 more
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Anti-virulence activities of some Tillandsia species (Bromeliaceae)
Botanical Sciences, 2020 Background: Using molecules that inhibit bacterial virulence is a potential strategy to fight infections, with the advantage that, in contrast to bactericidal compounds, they do not induce resistance. Several compounds with anti-virulence properties have been identified in plants, however, they represent a small portion of the total diversity, and in ...
Macrina Pérez-López +6 more
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