Results 31 to 40 of about 2,259,235 (294)

Structural characterisation of the virulence-associated protein VapG from the horse pathogen Rhodococcus equi [PDF]

, 2015
Virulence and host range in Rhodococcus equi depends on the variable pathogenicity island of their virulence plasmids. Notable gene products are a family of small secreted virulence-associated proteins (Vaps) that are critical to intramacrophagic ...
Blagova, Elena V., Okoko, Tebekeme, Dover, Lynn, Wilkinson, Anthony, Dover, Lynn G., Blagova, Elena, Whittingham, Jean L., Whittingham, Jean, Wilkinson, Anthony J.   +8 more
core   +1 more source

A Natural Dietary Flavone Myricetin as an α-Hemolysin Inhibitor for Controlling Staphylococcus aureus Infection

Frontiers in Cellular and Infection Microbiology, 2020
Staphylococcus aureus, an important agent for lethal bacterial infections, can cause a broad spectrum of diseases in various host species. The emergence of multidrug-resistant and highly virulent strains has raised increasing concerns about the novel ...
Tingting Wang, Tingting Wang, Peng Zhang, Hongfa Lv, Xuming Deng, Jianfeng Wang, Jianfeng Wang   +6 more
doaj   +1 more source

Novel anti-virulence compounds disrupt exotoxin expression in MRSA. [PDF]

Microbiol Spectr
Abstract Hemolysins are lytic exotoxins expressed in most strains of S. aureus , but hemolytic activity varies between strains. We have previously reported several novel anti-virulence compounds that disrupt the S.
Balogh H, Anthony AK, Stempel R, Vossen L, Federico VA, Valenzano GZ, Blackledge MS, Miller HB.   +7 more
europepmc   +5 more sources

Parasite variation and the evolution of virulence in a Daphnia-microparasite system [PDF]

, 2008
Understanding genetic relationships amongst the life-history traits of parasites is crucial for testing hypotheses on the evolution of virulence. This study therefore examined variation between parasite isolates (the bacterium Pasteuria ramosa) from the ...
Little, T. J., Chadwick, W., Watt, K.
core   +1 more source

Anti-virulence strategies for Clostridioides difficile infection: advances and roadblocks [PDF]

Gut Microbes, 2020
Clostridioides difficile infection (CDI) is a common healthcare- and antibiotic-associated diarrheal disease. If mis-diagnosed, or incompletely treated, CDI can have serious, indeed fatal, consequences. The clinical and economic burden imposed by CDI is great, and the US Centers for Disease Control and Prevention has named the causative agent, C ...
David Stewart, Farhan Anwar, Gayatri Vedantam   +2 more
openaire   +3 more sources

Salmonella stress response systems as targets for anti-virulence strategies. [PDF]

BMC Microbiol
Due to the rapid development of antibiotic resistance, novel strategies to cope with bacterial infections are urgently required. Ideally, these strategies should exert less selection pressure for resistance than traditional antibiotics. One potential approach is to target the bacterial stress response systems.
Hassanin A, Lories B, Steenackers HP.
europepmc   +3 more sources

The central metabolism regulator EIIAGlc switches Salmonella from growth arrest to acute virulence through activation of virulence factor secretion [PDF]

, 2014
The ability of Salmonella to cause disease depends on metabolic activities and virulence factors. Here, we show that a key metabolic protein, EIIAGlc, is absolutely essential for acute infection, but not for Salmonella survival, in a mouse typhoid fever ...
Timo Glatter, Dirk Bumann,, Glatter, Timo, Glatter, T. ; https://orcid.org/, Mazé, Alain, Bumann, Dirk, Timo Glatter,, Dirk Bumann, Alain Mazé, Maze, A., Alain Mazé,, Bumann, D.   +11 more
core   +1 more source

VFDB 2025: an integrated resource for exploring anti-virulence compounds. [PDF]

Nucleic Acids Res
Abstract With the escalating crisis of bacterial multidrug resistance, anti-virulence therapeutic strategies have emerged as a highly promising alternative to conventional antibiotic treatments. Anti-virulence compounds are specifically designed to target virulence factors (VFs), disarming pathogens without affecting bacterial growth and
Zhou S, Liu B, Zheng D, Chen L, Yang J.
europepmc   +3 more sources

Role of glucose and CcpA in capsule expression and virulence of Streptococcus suis [PDF]

, 2011
Streptococcus suis is one of the most important pathogens in pigs and is also an emerging zoonotic agent. After crossing the epithelial barrier, S. suis causes bacteraemia, resulting in meningitis, endocarditis and bronchopneumonia.
Smith, H.E., Smith, H E, H. E. Smith, R. Goethe, Rohde, Manfred, Valentin-Weigand, P., M. Rohde, Goethe, R, J. Willenborg, Willenborg, J, de Greeff, A, Goethe, R., Willenborg, J., A. de Greeff, Valentin-Weigand, P, De Greeff, A., Greeff, A., De, P. Valentin-Weigand, Fulde, M., M. Fulde, Fulde, M, Rohde, M.   +21 more
core   +1 more source

Curcumin Promotes the Clearance of Listeria monocytogenes both In Vitro and In Vivo by Reducing Listeriolysin O Oligomers

Frontiers in Immunology, 2017
The pore-forming toxin listeriolysin O (LLO), an essential virulence factor that is secreted by Listeria monocytogenes (L. monocytogenes), is responsible for bacterial breaching at the phagosomal membranes and subsequent release into the cytoplasm; it ...
Xuan Zhou, Xuan Zhou, Bing Zhang, Yumei Cui, Shuiye Chen, Zihao Teng, Gejin Lu, Jianfeng Wang, Xuming Deng, Xuming Deng   +9 more
doaj   +1 more source