Results 11 to 20 of about 2,259,235 (294)
Sortase A: An ideal target for anti-virulence drug development [PDF]
Microbial Pathogenesis, 2014 Sortase A is a membrane enzyme responsible for the anchoring of surface-exposed proteins to the cell wall envelope of Gram-positive bacteria. As a well-studied member of the sortase subfamily catalysing the cell wall anchoring of important virulence ...
Totsika, Makrina +4 more
core +4 more sources
Evaluation of novel compounds as anti-bacterial or anti-virulence agents [PDF]
Frontiers in Cellular and Infection MicrobiologyAntimicrobial resistance is a global threat, leading to an alarming increase in the prevalence of bacterial infections that can no longer be treated with available antibiotics. The World Health Organization estimates that by 2050 up to 10 million deaths per year could be associated with antimicrobial resistance, which would equal the annual number of ...
Slavica Filipic Slavica Oljacic +1 more
exaly +8 more sources
A Structural Approach to Anti-Virulence: A Discovery Pipeline [PDF]
Microorganisms, 2021 The anti-virulence strategy is designed to prevent bacterial virulence factors produced by pathogenic bacteria from initiating and sustaining an infection. One family of bacterial virulence factors is the mono-ADP-ribosyltransferase toxins, which are produced by pathogens as tools to compromise the target host cell.
Michael McCarthy +5 more
openaire +3 more sources
Considerations and caveats in anti-virulence drug development [PDF]
Current Opinion in Microbiology, 2016 As antibiotic resistance remains a major public health threat, anti-virulence therapy research is gaining interest. Hundreds of potential anti-virulence compounds have been examined, but very few have made it to clinical trials and none have been approved.
Damien, Maura +2 more
openaire +2 more sources
Targeting anti-virulence factor strategies of bacterial pathogens. [PDF]
Biosaf HealthAntibiotic-resistant bacterial pathogens pose substantial biosafety and health hazards, leading to millions of deaths each year. The evolution of bacterial virulence factors is mainly propelled by horizontal gene transfer (HGT). In addition to traditional antibiotics, antimicrobial strategies targeting biofilm-related virulence factors and quorum ...
Li J, Jia T, Yang L.
europepmc +4 more sources
Cryptococcal Meningitis and Anti-virulence Therapeutic Strategies [PDF]
Frontiers in Microbiology, 2019 Fungal infections of the central nervous system are responsible for significant morbidity and mortality. Cryptococcus neoformans (Cn) is the primary cause of fungal meningitis. Infection begins in the lung after inhalation of fungal spores but often spreads to other organs, particularly the brain in immunosuppressed individuals. Cn's ability to survive
Vu, Kiem, Garcia, Javier A, Gelli, Angie
openaire +5 more sources
Frontiers in Pharmacology, 2021 Many important bacterial pathogens are using the type III secretion system to deliver effectors into host cells. Salmonella Typhimurium (S. Typhimurium) is a pathogenic Gram-negative bacterium with the type III secretion system as its major virulence ...
Yong Zhang +6 more
doaj +1 more source
Frontiers in Microbiology, 2020 The type III secretion system (T3SS) consists of a syringe-like export machine injecting effectors from the bacterial cytosol directly into host cells to establish infection.
Yang Wu +3 more
doaj +1 more source
Antibiotics, 2022 Staphylococcus aureus is a fatal Gram-positive pathogen threatening numerous cases of hospital-admitted patients worldwide. The emerging resistance of the pathogen to several antimicrobial agents has pressurized research to propose new strategies for ...
Rana A. Elmesseri +4 more
doaj +1 more source
Quercitrin Is a Novel Inhibitor of Salmonella enterica Serovar Typhimurium Type III Secretion System
Molecules, 2023 The purpose was to screen type III secretory system (T3SS) inhibitors of Salmonella enterica serovar Typhimurium (S. Typhimurium) from natural compounds.
Qingjie Li +8 more
doaj +1 more source