Results 21 to 30 of about 2,259,235 (294)

Anti-virulence strategies to combat bacteria-mediated disease [PDF]

Nature Reviews Drug Discovery, 2010
Antibiotic resistance is one of the greatest challenges of the twenty-first century. However, the increasing understanding of bacterial pathogenesis and intercellular communication has revealed many potential strategies to develop novel drugs to treat bacteria-mediated disease.
David A, Rasko, Vanessa, Sperandio
openaire   +2 more sources

Antibacterial and anti-virulence effects of furazolidone on Trueperella pyogenes and Pseudomonas aeruginosa [PDF]

BMC Veterinary Research, 2021
Abstract Background Trueperella pyogenes and Pseudomonas aeruginosa are two important bacterial pathogens closely relating to the occurrence and development of forest musk deer respiratory purulent disease.
Qin Chen, Kelei Zhao, Heyue Li, Kanghua Liu, Jing Li, Yiwen Chu, Balakrishnan Prithiviraj, Bisong Yue, Xiuyue Zhang   +8 more
openaire   +3 more sources

Molecular Targets and Strategies for Inhibition of the Bacterial Type III Secretion System (T3SS); Inhibitors Directly Binding to T3SS Components

Biomolecules, 2021
The type III secretion system (T3SS) is a virulence apparatus used by many Gram-negative pathogenic bacteria to cause infections. Pathogens utilizing a T3SS are responsible for millions of infections yearly. Since many T3SS knockout strains are incapable
Julia A. Hotinger, Heather A. Pendergrass, Aaron E. May   +2 more
doaj   +1 more source

Bacterial adhesion inhibitor prevents infection in a rodent surgical incision model

Virulence, 2020
Surgical site infection risk continues to increase due to lack of efficacy in current standard of care drugs. New methods to treat or prevent antibiotic-resistant bacterial infections are needed.
R. M. Huebinger, D. H. Do, D. L. Carlson, X. Yao, D. H. Stones, M. De Souza Santos, D. P. Vaz, E. Keen, S. E. Wolf, JP Minei, K. P. Francis, K. Orth, A. M. Krachler   +12 more
doaj   +1 more source

The genome of a pathogenic rhodococcus : cooptive virulence underpinned by key gene acquisitions [PDF]

, 2010
We report the genome of the facultative intracellular parasite Rhodococcus equi, the only animal pathogen within the biotechnologically important actinobacterial genus Rhodococcus. The 5.0-Mb R.
Parkhill Julian, Cherevach, Inna, Iain Macarthur, Sanders Mandy, Leadon, Desmond, Prescott John F., Navas, Jesús, Michal Letek, González Patricia, Tom C. Freeman, Navas Méndez, Jesús, Valero-Rello, Ana, Ruth Fahey, Leadon Desmond, Bentley, Stephen D., Holdstock Jolyon, Ursula Fogarty, Scortti, Mariela M., Hapeshi, Alexia, José A. Vázquez-Boland, Inna Cherevach, Buckley, Tom, Rodríguez, Héctor M., Rodríguez Héctor, Ocampo Alain, Valero-Rello Ana, Fogarty Ursula, Valero Rello, Ana, Prescott, John F., Quail Michael A., Rodríguez, Héctor, Jolyon Holdstock, Alain Ocampo, Sanders, Mandy, Héctor Rodríguez, Fogarty, Ursula, Vázquez-Boland José A., Ana Valero-Rello, MacArthur Iain, Freeman Tom C., González, Patricia, Ocampo, Alain, Ana Valero-Rello, Fahey Ruth, Desmond Leadon, Cherevach Inna, Blanco, Mónica, Mariela M. Scortti, MacArthur, Iain, Vázquez Boland, José A., Bentley Stephen D., John F Prescott, Wim G. Meijer, Quail, Michael A., John F. Prescott, Stephen D. Bentley, Vázquez-Boland, José A., José A Vázquez-Boland, Holdstock, Jolyon, Stephen D Bentley, Letek Michal, Meijer, Wim G., Blanco Mónica, Meijer Wim G., Mónica Blanco, Ocampo Sosa, Alain Antonio, Tom C Freeman, Julian Parkhill, Jolyon Holdstock, Hapeshi Alexia, Tom Buckley, Wim G Meijer, Mandy Sanders, Michael A. Quail, Letek, Michal, Michael A Quail, Alexia Hapeshi, Scortti Mariela M., Parkhill, Julian, Navas Jesús, Patricia González, Mariela M Scortti, González, Patricia Jiménez, Buckley Tom, Freeman, Tom C., Fahey, Ruth, Jesús Navas   +86 more
core   +1 more source

Anti-virulence Strategies to Target Bacterial Infections [PDF]

, 2015
Resistance of important bacterial pathogens to common antimicrobial therapies and the emergence of multidrug-resistant bacteria are increasing at an alarming rate and constitute one of our greatest challenges in the combat of bacterial infection and accompanied diseases.
Mühlen, Sabrina, Dersch, Petra
openaire   +3 more sources

Attenuation of Aeromonas hydrophila Infection in Carassius auratus by YtnP, a N-acyl Homoserine Lactonase from Bacillus licheniformis T-1

Antibiotics, 2021
In this experiment, the quorum quenching gene ytnP of Bacillus licheniformis T-1 was cloned and expressed, and the effect against infection of Aeromonas hydrophila ATCC 7966 was evaluated in vitro and vivo.
Mengfan Peng, Wentao Tong, Zhen Zhao, Ling Xiao, Zhaoyue Wang, Xuanming Liu, Xuanhao He, Zengfu Song   +7 more
doaj   +1 more source

Parasite genetic diversity does not influence TNF-mediated effects on the virulence of primary rodent malaria infections [PDF]

, 2006
The pro-inflammatory cytokine tumour necrosis factor alpha (TNF-alpha) is associated with malaria virulence (disease severity) in both rodents and humans.
Long, G H, Read, A F, Read, A. F., Chan, Brian, Long, G. H., Graham, Andrea, A. F. READ, G. H. LONG, Allen, J. E., Chan, B H K, A. L. GRAHAM, J. E. ALLEN, Allen, Judith, Graham, A. L., Allen, J E, Graham, A L, B. H. K. CHAN, Read, Andrew F, Chan, B. H K; id_orcid, Long, Gráinne Helen   +19 more
core   +1 more source

The KdpD/KdpE two-component system : integrating K+ homeostasis and virulence [PDF]

, 2013
The two-component system (TCS) KdpD/KdpE, extensively studied for its regulatory role in potassium (K+) transport, has more recently been identified as an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria ...
Freeman, Zoë N., Zoë N Freeman, Steve Dorus, Waterfield, Nicholas R., Dorus, Steve, Nicholas R Waterfield   +5 more
core   +1 more source

Morin Protects Channel Catfish From Aeromonas hydrophila Infection by Blocking Aerolysin Activity

Frontiers in Microbiology, 2018
Aeromonas hydrophila (A. hydrophila) is an opportunistic bacterial pathogen widely distributed in the environments, particular aquatic environment. The pathogen can cause a range of infections in both human and animals including fishes.
Jing Dong, Jing Dong, Yongtao Liu, Yongtao Liu, Ning Xu, Ning Xu, Qiuhong Yang, Qiuhong Yang, Xiaohui Ai, Xiaohui Ai   +9 more
doaj   +1 more source