The Case against Antibiotics and for Anti-Virulence Therapeutics [PDF]
Microorganisms, 2021 Although antibiotics have been indispensable in the advancement of modern medicine, there are downsides to their use. Growing resistance to broad-spectrum antibiotics is leading to an epidemic of infections untreatable by first-line therapies. Resistance
Julia A. Hotinger +2 more
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Control Targets in Plant-Pathogenic Bacteria: From Growth-Essential Processes to Anti-Virulence Strategies and Candidate Targets in Candidatus Liberibacter Asiaticus [PDF]
PlantsPlant-pathogenic bacteria threaten crop productivity and quality, yet chemical options remain limited compared with those for fungal and oomycete diseases.
Jinyin Zeng +7 more
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Virulence factors and quorum sensing as targets of new therapeutic options by plant-derived compounds against bacterial infections caused by human and animal pathogens [PDF]
Veterinary World, 2023 The emergence of antibiotic-resistant bacteria and hospital-acquired bacterial infection has become rampant due to antibiotic overuse. Virulence factors are secondary to bacterial growth and are important in their pathogenesis, and therefore, new ...
Warangkana Kitpipit +6 more
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Peptidomimetics as Potential Anti-Virulence Drugs Against Resistant Bacterial Pathogens
Frontiers in Microbiology, 2022 The uncontrollable spread of superbugs calls for new approaches in dealing with microbial-antibiotic resistance. Accordingly, the anti-virulence approach has arisen as an attractive unconventional strategy to face multidrug-resistant pathogens.
Osmel Fleitas Martínez +4 more
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Biology, 2022 Quorum sensing (QS) controls the production of several bacterial virulence factors. There is accumulative evidence to support that targeting QS can ensure a significant diminishing of bacterial virulence.
Abrar K. Thabit +7 more
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Effect of Cinnamomum verum leaf essential oil on virulence factors of Candida species and determination of the in-vivo toxicity with Galleria mellonella model [PDF]
Memorias do Instituto Oswaldo Cruz, 2020 BACKGROUND Essential oils (EO) extracted from Cinnamomum verum has been used as an antimicrobial agents for centuries. The effects of C. verum leaf oil against virulence of microorganisms is not well studied yet.
Gayan Kanchana Wijesinghe +9 more
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mBio, 2022 Streptococcus agalactiae, otherwise known as Group B Streptococcus (GBS), is an opportunistic pathogen that vaginally colonizes approximately one third of healthy women.
Haider S. Manzer +7 more
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Molecules, 2023 As a major virulence factor of Listeria monocytogenes (L. monocytogenes), listeriolysin O (LLO) can assist in the immune escape of L. monocytogenes, which is critical for the pathogen to evade host immune recognition, leading to various infectious ...
Xiaoning Hou +10 more
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Palmatine Inhibits the Pathogenicity of Aeromonas hydrophila by Reducing Aerolysin Expression
Foods, 2022 Aeromonas hydrophila, an opportunistic aquatic pathogen widely spread in aquatic environments, is responsible for a number of infectious diseases in freshwater aquaculture. In addition, A.
Jing Dong +7 more
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Applications of Catechins in the Treatment of Bacterial Infections
Pathogens, 2021 Tea is the second most commonly consumed beverage worldwide. Along with its aromatic and delicate flavors that make it an enjoyable beverage, studies report numerous health advantages in tea consumption, including applications in antimicrobial therapy ...
Meishan Wu, Angela C. Brown
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